Conformational distortions induced by periodically recurring A…A in d(CAG).d(CAG) provide stereochemical rationale for the trapping of MSH2.MSH3 in polyQ disorders

por Ajjugal, Yogeeshwar, Rathinavelan, Thenmalarchelvi
Publicado 2021

Mechanistic and thermodynamic characterization of oxathiazolones as potent and selective covalent immunoproteasome inhibitors

por Mihalovits, Levente M., Ferenczy, György G., Keserű, György M.
Publicado 2021

Identification of subtypes correlated with tumor immunity and immunotherapy in cutaneous melanoma

por Liu, Qian, Nie, Rongfang, Li, Mengyuan, Li, Lin, Zhou, Haiying, Lu, Hui, Wang, Xiaosheng
Publicado 2021

ARMT: An automatic RNA-seq data mining tool based on comprehensive and integrative analysis in cancer research

por Huang, Guanda, Zhang, Haibo, Qu, Yimo, Huang, Kaitang, Gong, Xiaocheng, Wei, Jinfen, Du, Hongli
Publicado 2021

New insights into the acetate uptake transporter (AceTr) family: Unveiling amino acid residues critical for specificity and activity

por Rendulić, Toni, Alves, João, Azevedo-Silva, João, Soares-Silva, Isabel, Casal, Margarida
Publicado 2021

Neuroprotective derivatives of tacrine that target NMDA receptor and acetyl cholinesterase – Design, synthesis and biological evaluation

por Remya, Chandran, Dileep, K.V., Koti Reddy, Eeda, Mantosh, Kumar, Lakshmi, Kesavan, Sarah Jacob, Reena, Sajith, Ayyiliyath M., Jayadevi Variyar, E., Anwar, Shaik, Zhang, Kam Y.J., Sadasivan, C., Omkumar, R.V.
Publicado 2021

An overview of potential inhibitors targeting non-structural proteins 3 (PL(pro) and Mac1) and 5 (3CL(pro)/M(pro)) of SARS-CoV-2

por Yan, Fangfang, Gao, Feng
Publicado 2021

Advances in flux balance analysis by integrating machine learning and mechanism-based models

por Sahu, Ankur, Blätke, Mary-Ann, Szymański, Jędrzej Jakub, Töpfer, Nadine
Publicado 2021

TS-m6A-DL: Tissue-specific identification of N6-methyladenosine sites using a universal deep learning model

por Abbas, Zeeshan, Tayara, Hilal, Zou, Quan, Chong, Kil To
Publicado 2021

SCSit: A high-efficiency preprocessing tool for single-cell sequencing data from SPLiT-seq

por Luan, Mei-Wei, Lin, Jia-Lun, Wang, Ye-Fan, Liu, Yu-Xiao, Xiao, Chuan-Le, Wu, Rongling, Xie, Shang-Qian
Publicado 2021

The molecular feature of macrophages in tumor immune microenvironment of glioma patients

por Zhang, Hao, Luo, Yue-Bei, Wu, Wantao, Zhang, Liyang, Wang, Zeyu, Dai, Ziyu, Feng, Songshan, Cao, Hui, Cheng, Quan, Liu, Zhixiong
Publicado 2021

TSNAD v2.0: A one-stop software solution for tumor-specific neoantigen detection

por Zhou, Zhan, Wu, Jingcheng, Ren, Jianan, Chen, Wenfan, Zhao, Wenyi, Gu, Xun, Chi, Ying, He, Qiaojun, Yang, Bo, Wu, Jian, Chen, Shuqing
Publicado 2021

Implementing fluorescence enhancement, quenching, and FRET for investigating flap endonuclease 1 enzymatic reaction at the single-molecule level

por Sobhy, Mohamed A., Tehseen, Muhammad, Takahashi, Masateru, Bralić, Amer, De Biasio, Alfredo, Hamdan, Samir M.
Publicado 2021

FSL-Kla: A few-shot learning-based multi-feature hybrid system for lactylation site prediction

por Jiang, Peiran, Ning, Wanshan, Shi, Yunshu, Liu, Chuan, Mo, Saijun, Zhou, Haoran, Liu, Kangdong, Guo, Yaping
Publicado 2021

Predicting host dependency factors of pathogens in Drosophila melanogaster using machine learning

por Aromolaran, Olufemi, Beder, Thomas, Adedeji, Eunice, Ajamma, Yvonne, Oyelade, Jelili, Adebiyi, Ezekiel, Koenig, Rainer
Publicado 2021

A data-driven methodology towards evaluating the potential of drug repurposing hypotheses

por Prieto Santamaría, Lucía, Ugarte Carro, Esther, Díaz Uzquiano, Marina, Menasalvas Ruiz, Ernestina, Pérez Gallardo, Yuliana, Rodríguez-González, Alejandro
Publicado 2021

A review on machine learning approaches and trends in drug discovery

por Carracedo-Reboredo, Paula, Liñares-Blanco, Jose, Rodríguez-Fernández, Nereida, Cedrón, Francisco, Novoa, Francisco J., Carballal, Adrian, Maojo, Victor, Pazos, Alejandro, Fernandez-Lozano, Carlos
Publicado 2021

Fly-over phylogeny across invertebrate to vertebrate: The giant panda and insects share a highly similar gut microbiota

por Yao, Ran, Dai, Qinlong, Wu, Tonggui, Yang, Zhisong, Chen, Hua, Liu, Guoqi, Zhu, Yudong, Qi, Dunwu, Yang, Xu, Luo, Wei, Gu, Xiaodong, Yang, Xuyu, Zhu, Lifeng
Publicado 2021

Two alternative conformations of mRNA in the human ribosome during elongation and termination of translation as revealed by EPR spectroscopy

por Bulygin, Konstantin N., Timofeev, Ivan O., Malygin, Alexey A., Graifer, Dmitri M., Meschaninova, Maria I., Venyaminova, Alya G., Krumkacheva, Olesya A., Fedin, Matvey V., Yu. Frolova, Ludmila, Karpova, Galina G., Bagryanskaya, Elena G.
Publicado 2021

Contribution of sample processing to gut microbiome analysis in the model Lepidoptera, silkworm Bombyx mori

por Zhang, Nan, He, Jintao, Shen, Xiaoqiang, Sun, Chao, Muhammad, Abrar, Shao, Yongqi
Publicado 2021