Computational insights into O-glycosylation in a CTLA4 Fc-fusion protein linker and its impact on protein quality attributes

por Song, Yuanli, Qian, Yueming, Huang, Zhe, Khattak, Sarwat F., Li, Zheng Jian
Publicado 2020

Structure-based discovery of neoandrographolide as a novel inhibitor of Rab5 to suppress cancer growth

por Zhang, Jing, Sun, Yue, Zhong, Li-Ye, Yu, Nan-Nan, Ouyang, Lan, Fang, Run-Dong, Wang, Yang, He, Qing-Yu
Publicado 2020

Experimental and computational approaches to unravel microbial community assembly

por Aguirre de Cárcer, Daniel
Publicado 2020

In silico derived small molecules targeting the finger-finger interaction between the histone lysine methyltransferase NSD1 and Nizp1 repressor

por Berardi, Andrea, Ghitti, Michela, Quilici, Giacomo, Musco, Giovanna
Publicado 2020

Temperature dependence of the SARS-CoV-2 affinity to human ACE2 determines COVID-19 progression and clinical outcome

por Zhou, Zhonghua, Yang, Ziyi, Ou, Junxian, Zhang, Hong, Zhang, Qiwei, Dong, Ming, Zhang, Gong
Publicado 2020

Measuring the microbiome: Best practices for developing and benchmarking microbiomics methods

por Bokulich, Nicholas A., Ziemski, Michal, Robeson, Michael S., Kaehler, Benjamin D.
Publicado 2020

Leishmania: Responding to environmental signals and challenges without regulated transcription

por Grünebast, Janne, Clos, Joachim
Publicado 2020

Dosage-sensitive molecular mechanisms are associated with the tissue-specificity of traits and diseases

por Jubran, Juman, Hekselman, Idan, Novack, Lena, Yeger-Lotem, Esti
Publicado 2020

Microbial model communities: To understand complexity, harness the power of simplicity

por Bengtsson-Palme, Johan
Publicado 2020

Combining Ramachandran plot and molecular dynamics simulation for structural-based variant classification: Using TP53 variants as model

por Tam, Benjamin, Sinha, Siddharth, Wang, San Ming
Publicado 2020

Loss of Arp1, a putative actin-related protein, triggers filamentous and invasive growth and impairs pathogenicity in Candida albicans

por Yao, Shuangyan, Feng, Yuting, Islam, Amjad, Shrivastava, Manjari, Gu, Hongcheng, Lu, Yumeng, Sheng, Jiaqi, Whiteway, Malcolm, Feng, Jinrong
Publicado 2020

Derivation of a nuclear heterogeneity image index to grade DCIS

por Hayward, Mary-Kate, Louise Jones, J., Hall, Allison, King, Lorraine, Ironside, Alastair J., Nelson, Andrew C., Shelley Hwang, E., Weaver, Valerie M.
Publicado 2020

A recent origin of Orf3a from M protein across the coronavirus lineage arising by sharp divergence

por Ouzounis, Christos A.
Publicado 2020

2D Zernike polynomial expansion: Finding the protein-protein binding regions

por Milanetti, Edoardo, Miotto, Mattia, Di Rienzo, Lorenzo, Monti, Michele, Gosti, Giorgio, Ruocco, Giancarlo
Publicado 2020

Gut eukaryotic virome in colorectal carcinogenesis: Is that a trigger?

por Massimino, Luca, Lovisa, Sara, Antonio Lamparelli, Luigi, Danese, Silvio, Ungaro, Federica
Publicado 2020

Design of novel small molecule base-pair recognizers of toxic CUG RNA transcripts characteristics of DM1

por Ondono, Raul, Lirio, Ángel, Elvira, Carlos, Álvarez-Marimon, Elena, Provenzano, Claudia, Cardinali, Beatrice, Pérez-Alonso, Manuel, Perálvarez-Marín, Alex, Borrell, José I., Falcone, Germana, Estrada-Tejedor, Roger
Publicado 2020

FangNet: Mining herb hidden knowledge from TCM clinical effective formulas using structure network algorithm

por Bu, Dechao, Xia, Yan, Zhang, JiaYuan, Cao, Wanchen, Huo, Peipei, Wang, Zhihao, He, Zihao, Ding, Linyi, Wu, Yang, Zhang, Shan, Gao, Kai, Yu, He, Liu, Tiegang, Ding, Xia, Gu, Xiaohong, Zhao, Yi
Publicado 2020

In silico and in vitro insights into tyrosinase inhibitors with a 2-thioxooxazoline-4-one template

por Choi, Inkyu, Park, Yujin, Ryu, Il Young, Jung, Hee Jin, Ullah, Sultan, Choi, Heejeong, Park, Chaeun, Kang, Dongwan, Lee, Sanggwon, Chun, Pusoon, Young Chung, Hae, Moon, Hyung Ryong
Publicado 2020

Seeing the forest for the trees: Retrieving plant secondary biochemical pathways from metabolome networks

por Desmet, Sandrien, Brouckaert, Marlies, Boerjan, Wout, Morreel, Kris
Publicado 2020

Interplay of cholesterol, membrane bilayers and the AT1R: A cholesterol consensus motif on AT1R is revealed

por Kiriakidi, Sofia, Chatzigiannis, Christos, Papaemmanouil, Christina, Tzakos, Andreas G., Cournia, Zoe, Mavromoustakos, Thomas
Publicado 2020