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  1. 12141
    “…Various fermentation parameters were optimised for enhanced production of endoglucanase by employing Plackett-Burman design followed by Box-Behnken design. A well-fitted regression equation with R(2) value of 98.91% was attained for endoglucanase. …”
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    Fomitopsis meliae CFA 2, a novel brown rot for endoglucanase: emphasis towards enhanced endoglucanase production by statistical approach
  2. 12142
    “…In our study, FISH mapping using 18S-5.8S-25S rDNA and 5S rDNA sequences was performed for the first time on Ophrystenthredinifera Willdenow, 1805, Serapiasvomeracea (Burman f., 1770) Briquet, 1910 and Himantoglossumhircinum (Linnaeus, 1753) Sprengel, 1826. …”
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    Comparative chromosome studies in species of subtribe Orchidinae (Orchidaceae)
  3. 12143
    “…A statistics-based experimental design was used to optimize a liquid culture medium using inexpensive substrates for increasing its antifungal activity. A Plackett–Burman design was first applied to elucidate medium components having significant effects on antifungal production. …”
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    Optimization of Bacillus amyloliquefaciens BLB369 Culture Medium by Response Surface Methodology for Low Cost Production of Antifungal Activity
  4. 12144
    “…A partial least squares discriminant analysis (PLS-DA), stepwise linear discriminant analysis (SLDA), and decision tree (DT) are used to discriminate apples from 4 geographical regions (34 apple samples) and 3 botanical origins (36 apple samples). The most influential markers identified by PLS-DA are 2-hexadecanone, methyl decanoate, tetradecanal, 1,8-cineole, hexyl 2-butenoate, (Z)-2-octenal, methyl 2-methylbutanoate, ethyl butyrate, dimethyl trisulfide, methyl formate, ethanol, S(-)2-methyl-1-butanol, ethyl acetate, pentyl acetate, butyl butanoate, butyl acetate, and ethyl octanoate. …”
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    Characterization and Discrimination of Apples by Flash GC E-Nose: Geographical Regions and Botanical Origins Studies in China
  5. 12145
    “…According to the Plackett–Burman design, the response surface revealed glucose, magnesium sulfate, and ammonium sulfate as critical media components of the nutritional source, whereas the central composite design affirmed an optimum concentration of the critical nutritional source as 16.0 g/l (glucose), 3.5 g/l magnesium sulfate heptahydrate (MgSO(4).7H(2)O), and 1.6 g/l ammonium sulfate ( (NH(4))(2)SO(4)), yielding an optimal flocculation activity of 96.8%. …”
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    Bioflocculant produced by Bacillus velezensis and its potential application in brewery wastewater treatment
  6. 12146
    “…Evaluation of the method within analytical quality-by-design principles, including a central composite face-centered design for the sample derivatization process and Plackett–Burman robustness verification of the chromatographic conditions, indicated that the method has acceptable specificity toward excipients and degradants, accuracy [mean recovery = 99.5%, relative standard deviation (RSD) = 1.0%], linearity (=0.9986), precision (intraday = 96.1% of the label claim, RSD = 0.9%; interday = 96.3% label claim, RSD = 0.9%), and high sensitivity with detection limits of 0.01 μg/mL. …”
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    Gas chromatographic method for the determination of lumefantrine in antimalarial finished pharmaceutical products
  7. 12147
    “…An analysis of pathways revealed that butanoate metabolism and the synthesis and degradation of branched-chain amino acids and ketone bodies are involved in the beneficial impact of cocoa on diabetes. …”
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    Urinary Metabolomics Study on the Protective Role of Cocoa in Zucker Diabetic Rats via (1)H-NMR-Based Approach
  8. 12148
    “…To the best of our knowledge, compound 1 is the first example of a natural isoindolinone with a butanoic acid moiety, and this study is the first to detect the other known compounds (2–9) in C. molybdites. …”
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    Meyeroguilline E, a New Isoindolinone Alkaloid from the Poisonous Mushroom Chlorophyllum molybdites, and Identification of Compounds with Multidrug Resistance (MDR) Reversal Activities
  9. 12149
    “…Moreover, the global patterns for the plasma metabolome were altered, e.g., the decreased butanoate metabolism intermediates in SD mice. In addition, disrupted metabolic homeostasis in the SD atrium, such as fatty acid metabolism, was analyzed by the transcriptome. …”
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    The Impact of Sleep Disturbance on Gut Microbiota, Atrial Substrate, and Atrial Fibrillation Inducibility in Mice: A Multi-Omics Analysis
  10. 12150
    “…E-2-pentenal, 2-heptenal (E), and methyl 2-methyl butanoate were identified only in DFSM. In addition, a total of 16 free amino acids (FAAs) were detected in shrimp meat. …”
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    Study on the physicochemical and flavor characteristics of air frying and deep frying shrimp (crayfish) meat
  11. 12151
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    A direct link between MITF, innate immunity, and hair graying
  12. 12152
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    The authors reply: Letter on: “Pitfalls in the measurement of muscle mass: a need for a reference standard” by Clark et al.
  13. 12153
    “…Focusing on the aromatic black rice, the samples appeared to contain high level of both compound groups of aldehydes (3-methylbutanal, 2-methylbutanal, 2-methylpropanal, pentanal, hexanal) and alcohols (butane-2,3-diol, pentan-1-ol, hexan-1-ol). Biosynthetically, these distinctive black-rice volatile compounds were proposed to be formed from the metabolic degradation of branched-chain amino acids (L-leucine, L-isoleucine and L-valine) and polyunsaturated fatty acids (linoleic acid and α-linolenic acid), involving the branched-chain aminotransferases and keto-acid decarboxylases and the 9-lipoxygonases and 13-lipoxygeases, respectively. …”
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    Metabolomics approach to identify key volatile aromas in Thai colored rice cultivars
  14. 12154
    “…METHODS: The compounds were synthesized by reacting 5,5’-butane-bis-1,2,4-triazole derivatives with prenyl bromide. …”
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    Synthesis, Biological Evaluation and Molecular Docking Studies of Novel Series of Bis-1,2,4-Triazoles as Thymidine Phosphorylase Inhibitor
  15. 12155
    “…Short-chain alkanes play a substantial role in carbon and sulfur cycling at hydrocarbon-rich environments globally, yet few studies have examined the metabolism of ethane (C(2)), propane (C(3)), and butane (C(4)) in anoxic sediments in contrast to methane (C(1)). …”
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    Anaerobic oxidation of short-chain alkanes in hydrothermal sediments: potential influences on sulfur cycling and microbial diversity
  16. 12156
    “…KC LT had the highest (p<0.05) concentrations of acetaldehyde, 3-methyl butanal, and 3-hydroxy-2-butanone, and these volatile compounds were positively correlated (p<0.05) with all the sensory traits. …”
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    Comparison of reducing sugar content, sensory traits, and fatty acids and volatile compound profiles of the longissimus thoracis among Korean cattle, Holsteins, and Angus steers
  17. 12157
    “…Ruthenium complexes with piplartine, [Ru(piplartine)(dppf)(bipy)](PF(6))(2) (1) and [Ru(piplartine)(dppb)(bipy)](PF(6))(2) (2) (dppf = 1,1-bis(diphenylphosphino) ferrocene; dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2′-bipyridine), were recently synthesized and displayed more potent cytotoxicity than piplartine in different cancer cells, regulated RNA transcripts of several apoptosis-related genes, and induced reactive oxygen species (ROS)-mediated apoptosis in human colon carcinoma HCT116 cells. …”
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    Ruthenium Complexes With Piplartine Cause Apoptosis Through MAPK Signaling by a p53-Dependent Pathway in Human Colon Carcinoma Cells and Inhibit Tumor Development in a Xenograft Model
  18. 12158
    “…Comprehensive biomarker screening detected 9 potential metabolite markers for the discrimination among RDM and CDM, including L-glutamate, gamma-aminobutyric acid, and butane-1, 2, 3, 4-tetrol. Moreover, a total of 992 and 1,022 lipids belonging to 12 subclasses were identified in RDM and CDM, respectively, mainly including triglycerides (TGs) and glycerophospholipids (GPs). …”
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    Comparing the Profiles of Raw and Cooked Donkey Meat by Metabonomics and Lipidomics Assessment
  19. 12159
    “…Eleven detected compounds had no association with liking, for example, butane‐2,3‐dione (butter, fruit like). Practical Application: The result of this study may be applied to formulate coffee‐flavored dairy beverages to maximize consumer acceptance and aroma‐liking. …”
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    Identifying aroma‐active compounds in coffee‐flavored dairy beverages
  20. 12160
    “…A medida que la situación económica a nivel global es afectada por la crisis económica provocada por el COVID-19, las empresas y usuarios del sistema financiero, buscan la mejor herramienta para reactivar sus fuentes de trabajo y obtener ingresos. …”
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    Stablecoin: una fuente de inversión en tiempos de crisis económicas
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