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  1. 12741
    “…The response surface methodology (RSM) with Plackett–Burman design (PBD) and Box-Behnken design (BBD) models were employed to optimize conditions in the EP-MAE method. …”
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    Optimization of enzyme-assisted microwave extraction of Zanthoxylum limonella essential oil using response surface methodology
  2. 12742
    “…To illustrate the impact of contour variation on NTCP estimates, we applied two equations predicting fibrosis grade [Formula: see text] 2 at 5 years, based on Lyman-Kutcher-Burman (LKB) and Relative Seriality (RS) models, respectively, to each contour. …”
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    Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy
  3. 12743
    “…We aimed at improving the pharmacokinetics of radiolabeled DOTA-NAPamide compounds by incorporating a 4-(p-iodo-phenyl)-butanoic acid (IPB) into the molecules. Followed by (68)Ga-, (205/206)Bi-, and (177)Lu-labelling, the radiopharmaceuticals ([(68)Ga]Ga-DOTA-IPB-NAPamide, [(205/206)Bi]Bi-DOTA-IPB-NAPamide, [(177)Lu]Lu-DOTA-IPB-NAPamide) were characterized in vitro. …”
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    Investigation of the Effect on the Albumin Binding Moiety for the Pharmacokinetic Properties of (68)Ga-, (205/206)Bi-, and (177)Lu-Labeled NAPamide-Based Radiopharmaceuticals
  4. 12744
    “…The isolated cyanobacterial alginate was identified using a set of tests, including FTIR, TLC, HPLC, GC–MS, and (1)H NMR. Plackett–Burman statistical design showed that working volume (X1), the incubation period (X2), and inoculum size (X3) are the most significant variables affecting the production of alginate. …”
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    Identification and statistical optimization of a novel alginate polymer extracted from newly isolated Synechocystis algini MNE ON864447 with antibacterial activity
  5. 12745
    “…KEGG enrichment analysis showed that purine metabolism, arginine and proline metabolism, alanine, aspartate, and glutamate metabolism, butanoate metabolism, and histidine metabolism may contribute to the development of sarcopenia. …”
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    Characteristics of the gut microbiome and metabolic profile in elderly patients with sarcopenia
  6. 12746
    “…DL-2-hydroxy-4-(methylthio)-butanoic acid (DL-HMTBA) has been considered as an important source of methionine. …”
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    Dietary methionine sources and levels modulate the intestinal health status of broiler chickens
  7. 12747
    “…Fit of toxicity incidence by the Lyman-Burman-Kutcher (LKB) model was performed. RESULTS: The crude incidence of late rectal toxicity ≥ G2 was 14% and 12% for the standard arm and the hypofractionated arm, respectively. …”
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    Modeling of α/β for late rectal toxicity from a randomized phase II study: conventional versus hypofractionated scheme for localized prostate cancer
  8. 12748
    “…This manuscript was reviewed by: Ford Doolittle, Tal Pupko, Richard Burian, James McInerney, Didier Raoult, and Yan Boucher…”
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    Of woods and webs: possible alternatives to the tree of life for studying genomic fluidity in E. coli
  9. 12749
    “…Rectum dose-volume histograms were extracted for Lyman-Kutcher-Burman (LKB) NTCP model fitting using Maximum Likelihood Estimation. …”
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    Prediction of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer
  10. 12750
    “…Rapid metabolite profiling and enzyme-linked immunosorbent assay were used to quantify endophyte alkaloids and mycelial mass (MM) in leaves harvested, in consecutive autumns, from an F(1) mapping population hosting standard toxic endophyte. …”
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    A QTL analysis of host plant effects on fungal endophyte biomass and alkaloid expression in perennial ryegrass
  11. 12751
    “…With the aim of developing potential leads for anti-Alzheimer’s drugs, in this study we synthesized a novel GABA derivative, methyl 4-(4-((2-(tert-butoxy)-2-oxoethyl)(4-methoxyphenyl)amino)benzamido)butanoate by a unique method of Buchwald–Hartwig cross coupling synthesis; with some modification the yield was significant (97 %) and spectroscopic analysis confirmed that the compound was highly pure (98.8 % by HPLC). …”
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    Binding interaction of a gamma-aminobutyric acid derivative with serum albumin: an insight by fluorescence and molecular modeling analysis
  12. 12752
    “…SSF was initially optimized with different agro-waste residues, among them sweet sorghum bagasse was found to be the best substrate that favored maximum xylanase production (9643 U/g). Plackett–Burman and response surface methodology employing central composite design were used to optimize the process parameters for the production of xylanase under SSF. …”
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    Xylanase production from Penicillium citrinum isolate HZN13 using response surface methodology and characterization of immobilized xylanase on glutaraldehyde-activated calcium-alginate beads
  13. 12753
    “…Dose-volume histogram, mean doses of target and normal tissues (rectum, bladder and femoral heads), dose-volume points (D(99%) of planning target volume; D(30%), D(50%), V(30 Gy) and V(35 Gy) of rectum and bladder; D(5%), V(14 Gy), V(22 Gy) of femoral heads), conformity index (CI), homogeneity index (HI), gradient index (GI), prostate tumor control probability (TCP), and rectal normal tissue complication probability (NTCP) based on the Lyman-Burman-Kutcher algorithm were calculated for each IMRT and VMAT plan. …”
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    Dosimetric and radiobiological characterizations of prostate intensity-modulated radiotherapy and volumetric-modulated arc therapy: A single-institution review of ninety cases
  14. 12754
    “…Response surface methodology was used to enhance the production of α-galactosidase from Fusarium moniliforme NCIM 1099 in solid-state fermentation. Plackett–Burman design was employed for selection of critical media constituents which were optimized by central composite rotatable design. …”
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    Response surface methodology-based optimization of production media and purification of α-galactosidase in solid-state fermentation by Fusarium moniliforme NCIM 1099
  15. 12755
    “…RESULTS: The important factors influencing antibiotic production selected in accordance with the Plackett–Burman design were found to be initial pH, temperature, peptone, MgSO(4).7H(2)O. …”
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    Enhanced candicidal compound production by a new soil isolate Penicillium verruculosum MKH7 under submerged fermentation
  16. 12756
    “…Rectal NTCP grade ≥2 was evaluated with the Lyman–Kutcher–Burman model and TCP was estimated by a logistic model using the combined MRI positive volume in SV and prostate as region-of-interest. …”
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    A modeling study of functional magnetic resonance imaging to individualize target definition of seminal vesicles for external beam radiotherapy
  17. 12757
    “…We found that the main pollinator for L. cognata, Bhutanitis yulongensis (Papilionodae) generally preferred M1 flowers. …”
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    Slow stamen movement in a perennial herb decreases male–male and male–female interference
  18. 12758
    por Chow, James C.L., Jiang, Runqing
    Publicado 2013
    “…For comparison, the monitor unit based on the RapidArc delivery method, prostate tumor control probability (TCP), and rectal normal tissue complication probability (NTCP) based on the Lyman‐Burman‐Kutcher algorithm were calculated. It was found that though the double‐arc technique required almost double the treatment time than the single‐arc, the double‐arc plan provided a better rectal and bladder dose‐volume criteria by shifting the delivered dose in the patient from the anterior–posterior direction to the lateral. …”
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    Prostate volumetric‐modulated arc therapy: dosimetry and radiobiological model variation between the single‐arc and double‐arc technique
  19. 12759
    “…A lower ruminal butyrate concentration is possibly associated with enrichment of the “butanoate metabolism” pathway in Tasco-fed rams. The ruminal total E. coli population was linearly reduced (P < 0.001) by Tasco. …”
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    Air-Dried Brown Seaweed, Ascophyllum nodosum, Alters the Rumen Microbiome in a Manner That Changes Rumen Fermentation Profiles and Lowers the Prevalence of Foodborne Pathogens
  20. 12760
    “…Thereafter, the Plackett-Burman design (PBD) was used to ascertain the three most significant factors affecting the vaccine yields, followed by the paths of steepest ascent to move to the nearest region of maximum response. …”
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    Optimization of fermentation conditions for an Escherichia coli strain engineered using the response surface method to produce a novel therapeutic DNA vaccine for rheumatoid arthritis
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