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5161por Hur, Junguk, Sullivan, Kelli A., Callaghan, Brian C., Pop-Busui, Rodica, Feldman, Eva L.“…RESEARCH DESIGN AND METHODS: Demographic, anthropometric, biochemical, and anatomical data of subjects with DN from a 52-week trial of acetyl-L-carnitine were retrospectively examined. Based on the change in sural nerve myelinated fiber density (ΔMFD%), subjects were divided into three groups: regenerator (top 16 percentiles, n = 67), degenerator (bottom 16 percentiles, n = 67), and intermediate (n = 290), with dramatically increased, decreased, and steady ΔMFD%, respectively. …”
Publicado 2013
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5162por Brun, Thierry, Scarcia, Pasquale, Li, Ning, Gaudet, Pascale, Duhamel, Dominique, Palmieri, Ferdinando, Maechler, Pierre“…Both saturated and unsaturated fatty acids increased expression of the carnitine/acylcarnitine carrier CAC, whereas the citrate carrier CIC and energy sensor SIRT1 were specifically upregulated by palmitate and oleate, respectively. …”
Publicado 2013
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5163por Mai, Manuel, Tönjes, Anke, Kovacs, Peter, Stumvoll, Michael, Fiedler, Georg Martin, Leichtle, Alexander Benedikt“…Serum concentrations of free carnitine and 24 acylcarnitines were measured by mass spectrometry. …”
Publicado 2013
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5164por Dunning, Kylie R., Anastasi, Marie R., Zhang, Voueleng J., Russell, Darryl L., Robker, Rebecca L.“…Analysis of genes involved in fatty acid oxidation showed that many are regulated by the luteinizing hormone surge during in vivo maturation, including acyl-CoA synthetases, carnitine transporters, acyl-CoA dehydrogenases and acetyl-CoA transferase, but that many are dysregulated when cumulus-oocyte complexes are matured under in vitro maturation conditions using follicle stimulating hormone and epidermal growth factor. …”
Publicado 2014
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5165por Carrier, Bradley, Wen, Shin, Zigouras, Sophia, Browne, Richard W., Li, Zhuyun, Patel, Mulchand S., Williamson, David L., Rideout, Todd C.“…Compared with the HF-fed animals, livers of LA-supplemented animals were protected against TG accumulation (−46%), likely through multiple mechanisms including: a suppressed lipogenic response (down-regulation of hepatic acetyl-CoA carboxylase and fatty acid synthase expression); enhanced hepatic fat oxidation (increased carnitine palmitoyltransferase Iα expression); and enhanced VLDL export (increased hepatic diacylglycerol acyltransferase and microsomal triglyceride transfer protein expression and elevated plasma VLDL particle number). …”
Publicado 2014
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5166por Schäfer, Nadine, Yu, Zhonghao, Wagener, Asja, Millrose, Marion K., Reissmann, Monika, Bortfeldt, Ralf, Dieterich, Christoph, Adamski, Jerzy, Wang-Sattler, Rui, Illig, Thomas, Brockmann, Gudrun A.“…The levels of 22 diacyl-phosphatidylcholines (PC aa), two lyso-PC and three carnitines were found to be significantly lower in obese mice compared with lean mice, while serine, glycine, arginine and hydroxysphingomyelin were higher for the same comparison. …”
Publicado 2013
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5167“…Real-time PCR results showed that ApoVLDL-II mRNA expression had a tendency to increase, genes including sterol regulatory element-binding protein-1 (SREBP-1), acetyl coenzyme A carboxylase α (ACCα), carnitine palmitoyltransferase 1 (CPT1), 3-hydroxyl-3-methylglutaryl-coenzyme A reductases (HMGCR) and stearyl coenzyme A dehydrogenase-1 (SCD1) mRNA in hepatocytes were significantly down-regulated by 100 nM Kp-10. …”
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5168Roles and Regulation of Ketogenesis in Cultured Astroglia and Neurons Under Hypoxia and Hypoglycemiapor Takahashi, Shinichi, Iizumi, Takuya, Mashima, Kyoko, Abe, Takato, Suzuki, Norihiro“…Palmitic acid (PAL) and l-carnitine (LC) were added to the assay medium. The 4- to 24-hr production of AA and BHB was measured using the cyclic thio-NADH method. (14)C-labeled acid-soluble products (KBs) and (14)CO(2) produced from [1-(14)C]PAL were also measured. l-[U-(14)C]lactic acid ([(14)C]LAC), [1-(14)C]pyruvic acid ([(14)C]PYR), or β-[1-(14)C]hydroxybutyric acid ([(14)C]BHB) was used to compare the oxidative metabolism of the glycolysis end products with that of the KBs. …”
Publicado 2014
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5169“…We quantified changes in key enzymes in aerobic and carbohydrate metabolism [citrate synthase (CS), β-hydroxyacyl-CoA dehydrogenase (HOAD), hexokinase (HK)] and changes in mRNA expression of major regulators of metabolic phenotype (AMPK, PPARs) and lipid (carnitine palmitoyltransferase, CPT I), protein (aspartate aminotransferase, AST) and carbohydrate (HK) oxidation pathways. …”
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5170por Choi, S. H., Park, S. K., Johnson, B. J., Chung, K. Y., Choi, C. W., Kim, K. H., Kim, W. Y., Smith, B.“…All fatty acid treatments increased (p = 0.001) carnitine palmitoyltransferase-1 beta (CPT1β) gene expression, but the increase in CPT1β gene expression was especially pronounced in IPA incubated with palmitic and stearic acid (6- to 17- fold increases). …”
Publicado 2015
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5171por Gao, Su, McMillan, Ryan P., Zhu, Qingzhang, Lopaschuk, Gary D., Hulver, Matthew W., Butler, Andrew A.“…The underlying mechanisms appear to involve suppressions of carnitine palmitoyltransferase-1B (CPT-1B) and CD36, two key enzymes in fatty acid utilization. …”
Publicado 2015
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5172“…At protein level, mitochondrial genes (peroxisome proliferator-activated receptor gamma coactivator 1 alpha [PGC1α] and nuclear respiratory factor-1 [nrf1]) and β-oxidation related genes (carnitine palmitoyltransferase 1A [CPT1a] and peroxisome proliferator-activated receptor alpha [PPARα]) were upregulated by dietary ALA in epididymal fat of WT mice. …”
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5173por Burelle, Yan, Bemeur, Chantal, Rivard, Marie-Eve, Thompson Legault, Julie, Boucher, Gabrielle, Morin, Charles, Coderre, Lise, Des Rosiers, Christine“…Furthermore, we demonstrate that compounds that are known to promote flux through the electron transport chain independent of phosphorylation (methylene blue, dinitrophenol), or modulate fatty acid (L-carnitine) or Krebs cycle metabolism (propionate) are protective, while antioxidants (idebenone, N-acetyl cysteine, resveratrol) exacerbate palmitate plus lactate-induced cell death. …”
Publicado 2015
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5174por Zordoky, Beshay N., Sung, Miranda M., Ezekowitz, Justin, Mandal, Rupasri, Han, Beomsoo, Bjorndahl, Trent C., Bouatra, Souhaila, Anderson, Todd, Oudit, Gavin Y., Wishart, David S., Dyck, Jason R. B.“…Compared to non-HF control, HFpEF patients demonstrated higher serum concentrations of acylcarnitines, carnitine, creatinine, betaine, and amino acids; and lower levels of phosphatidylcholines, lysophosphatidylcholines, and sphingomyelins. …”
Publicado 2015
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5175por Lim, Dajeong, Chai, Han-Ha, Lee, Seung-Hwan, Cho, Yong-Min, Choi, Jung-Woo, Kim, Nam-Kuk“…Ten genes, retinoid X receptor alpha, peroxisome proliferator-activated receptor gamma (PPARG), phospholipid transfer protein, stearoyl-CoA desaturase, nuclear receptor subfamily 1 group H member 3, fatty acid binding protein 3 (FABP3), carnitine palmitoyltransferase II, acyl-Coenzyme A dehydrogenase long chain (ACADL), acyl-Coenzyme A oxidase 2 branched chain, and fatty acid binding protein 4, showed significant effects with regard to IMF and were differentially expressed between the low- and high-marbled groups (p<0.05). …”
Publicado 2015
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5176por Branco, Ana F., Pereira, Susana P., Gonzalez, Susana, Gusev, Oleg, Rizvanov, Albert A., Oliveira, Paulo J.“…The results show that RA-induced H9c2 differentiation increased the expression of genes encoding for cardiac sarcomeric proteins such as troponin T, or calcium transporters and associated machinery, including SERCA2, ryanodine receptor and phospholamban as well as genes associated with mitochondrial energy production including respiratory chain complexes subunits, mitochondrial creatine kinase, carnitine palmitoyltransferase I and uncoupling proteins. …”
Publicado 2015
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5177por Vida, Margarita, Gavito, Ana Luisa, Pavón, Francisco Javier, Bautista, Dolores, Serrano, Antonia, Suarez, Juan, Arrabal, Sergio, Decara, Juan, Romero-Cuevas, Miguel, Rodríguez de Fonseca, Fernando, Baixeras, Elena“…Obesity in WT mice fed a HFD associated with elevated serum IL-6 levels, fatty liver, upregulation of carnitine palmitoyltransferase 1 (CPT1) and signal transducer and activator of transcription-3 (STAT3), increased AMP kinase phosphorylation (p-AMPK), and downregulation of the hepatic lipogenic enzymes fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD1). …”
Publicado 2015
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5178por Dynnik, Vladimir V., Kononov, Alexey V., Sergeev, Alexander I., Teplov, Iliya Y., Tankanag, Arina V., Zinchenko, Valery P.“…Network activity may also be slowed down by glycine, agonists of metabotropic inhibitory receptors, betaine, L-carnitine, L-arginine, etc. CONCLUSIONS: Obtained results demonstrate that ammonium ions accelerate neuronal networks firing, implicating ionotropic glutamate receptors, having preserved the activities of group of inhibitory ionotropic and metabotropic receptors. …”
Publicado 2015
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5179por De Luca, Arianna, Fiorillo, Marco, Peiris-Pagès, Maria, Ozsvari, Bela, Smith, Duncan L., Sanchez-Alvarez, Rosa, Martinez-Outschoorn, Ubaldo E., Cappello, Anna Rita, Pezzi, Vincenzo, Lisanti, Michael P., Sotgia, Federica“…We also show that XCT790 markedly reduces oxidative mitochondrial metabolism (OXPHOS) and that XCT790-mediated inhibition of CSC propagation can be prevented or reversed by Acetyl-L-Carnitine (ALCAR), a mitochondrial fuel. Consistent with our findings, over-expression of ERRα significantly enhances the efficiency of mammosphere formation, which can be blocked by treatment with mitochondrial inhibitors. …”
Publicado 2015
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5180por Vatner, Daniel F., Snikeris, Jaclyn, Popov, Violeta, Perry, Rachel J., Rahimi, Yasmeen, Samuel, Varman T.“…There was no change in expression of genes thought to mediate the effect of T2 on hepatic metabolism, including genes that regulate hepatic lipid oxidation (ppara, carnitine palmitoyltransferase 1a), genes that regulate hepatic fatty acid synthesis (srebp1c, acetyl coa carboxylase, fatty acid synthase), and genes involved in glycolysis and gluconeogenesis (L-pyruvate kinase, glucose 6 phosphatase). …”
Publicado 2015
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