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5261“…MBC promoted the lipid oxidation factor peroxisome proliferator activated receptor-α (Pparα), and its target genes, carnitine palmitoyl transferase 1 (Cpt1) and acyl-coenzyme A oxidase 1 (Acox1) in both the SK-HEP-1 cells and primary murine hepatocytes. …”
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5262por Tröscher-Mußotter, Johanna, Saenz, Johan S., Grindler, Sandra, Meyer, Jennifer, Kononov, Susanne U., Mezger, Beate, Borda-Molina, Daniel, Frahm, Jana, Dänicke, Sven, Camarinha-Silva, Amélia, Huber, Korinna, Seifert, Jana“…This long-term study investigated the effects of calving, lipopolysaccharide (LPS)-induced inflammation, and l-carnitine supplementation on fecal bacteria and metabolites, dairy cow milk production, health, energy metabolism, and blood metabolites. …”
Publicado 2021
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5263por Hu, Xiaomin, Fan, Yue, Li, Hanyu, Zhou, Ruilin, Zhao, Xinyue, Sun, Yueshen, Zhang, Shuyang“…In the untargeted serum metabolomic study, we observed and annotated 304 discriminant metabolites, uniquely including ceramides, acyl carnitines, and glycerophospholipids. Pathway analysis revealed a significantly changed sphingolipids metabolism related to cigarette smoking. …”
Publicado 2021
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5264por Wu, Qiong, Li, Jiankang, Sun, Xiaohui, He, Di, Cheng, Zongxue, Li, Jun, Zhang, Xuhui, Xie, Yongming, Zhu, Yimin, Lai, Maode“…Five metabolites, including LysoPC(14:0), LysoPC(15:0), propionyl carnitine, phenylalanine, and docosapentaenoic acid (DPA) were selected to construct a metabolite risk score (MRS), which was found to have a dose-response relationship with MetS and metabolic abnormalities. …”
Publicado 2021
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5265“…Trimethylamine N-oxide (TMAO) and its precursors, including choline, betaine, and L-carnitine, are gut microbiota-related metabolites associated with the risk of obesity. …”
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5266por Afrouziyeh, Mohammad, Zukiwsky, Nicole M., Korver, Douglas R., Zuidhof, Martin J.“…Further investigation of differential metabolites showed 15 potential biomarkers for pullet to hen transition by analyzing the receiver operating characteristic (ROC) curve, mainly consisting of carnitine and choline metabolites. Differential metabolites during the pullet to hen transition were mainly associated with lipid, energy, and amino acid metabolism pathways, which gave clues to the physiological and metabolic shifts resulting from sexual maturation. …”
Publicado 2021
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5267“…Background: Although newborn screening (NBS) for metabolic defects using the marker butyl carnitine (C4) combined with the C4-to-acetylcarnitine ratio is adequate, the incorporation of novel parameters may improve differential testing for these disorders without compromising sensitivity. …”
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5268por Ramireddy, Latha, Tsen, Hau-Yang, Chiang, Yu-Chen, Hung, Chen-Ying, Wu, Shih-Rong, Young, San-Land, Lin, Jin-Seng, Huang, Chien-Hsun, Chiu, Shih-Hau, Chen, Chien-Chi, Chen, Chih-Chieh“…TMA is produced by its dietary precursors such as choline, carnitine, and phosphatidylcholine by gut microbiota. …”
Publicado 2021
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5269“…However, in the serum, very-low-density lipoprotein and hepatic contents (hormone-sensitive triglyceride lipase, Acetyl CoA carboxylase, carnitine palmitoyltransterase, and mirosomal triglygeride transfer protein) decreased markedly in M8 (p < 0.05). …”
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5270por Zhang, Mingyu, Buckley, Jessie P, Liang, Liming, Hong, Xiumei, Wang, Guoying, Wang, Mei-Cheng, Wills-Karp, Marsha, Wang, Xiaobin, Mueller, Noel T“…Se and Mn shared associations with 6 metabolites (in both directions), which mostly included nucleotides and amino acids; Se was additionally associated with 7 metabolites (mostly amino acids, nucleotides, and carnitines) and Mn was additionally associated with C36:4 hydroxy phosphatidylcholine. …”
Publicado 2021
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5271“…The most common disorders in the region were primary carnitine deficiency, hyperphenylalaninemia and short-chain acyl-CoA dehydrogenase deficiency. …”
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5272“…RESULTS/ANTICIPATED RESULTS: Significant metabolomic differences were related to biosynthetic intermediates of redox cofactors nicotinamide adenine dinucleotide (NAD) and NAD phosphate (NADP), increased acyl-carnitines, and decreased acyl-glycerophosphocholines in nonsurvivors compared to survivors. …”
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5273“…RESULTS: Relative to healthy controls, Phe catabolites, ketones, and carnitine- and glycine-conjugated fatty acids were elevated in females with PKU at baseline, whereas fatty acylcholine metabolites were substantially lower. …”
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5274por Pereyra, Andrea S., Lin, Chien-Te, Sanchez, Daniela Mesa, Laskin, Julia, Spangenburg, Espen E., Neufer, P. Darrell, Fisher–Wellman, Kelsey, Ellis, Jessica M.“…METHODS: Mice with defective mitochondrial long-chain fatty acid oxidation (mLCFAO) in the skeletal muscle due to loss of carnitine palmitoyltransferase 2 (Cpt2(Sk−/−)) were used to model a shift in muscle macronutrient catabolism. …”
Publicado 2022
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5275por Gong, Wei-Jing, Cao, Peng, Zhang, Qi-Lin, Han, Xiao-Yu, Wang, Shuo-Wen, Huang, Yi-Fei, Wu, San-Lan, Li, Qiang, Zhang, Rui, Xu, Shuang-Bing, Liu, Ya-Ni, Shi, Shao-Jun, Zhang, Yu“…A panel incorporating triglyceride 14:0/22:3/22:5, 3-(3-Hydroxyphenyl) Propionate Acid, and Carnitine C18:0 was the best predictive ability of hematological toxicity with an AUROC of 0.7954. 54 differential expressed metabolites were found to be associated with hepatotoxicity of pemetrexed plus platinum chemotherapy. …”
Publicado 2022
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5276“…In comparison, grafts for the mice belonging to the HF groups exhibited higher expression of lipolysis-related genes, including adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and carnitine palmitoyltransferase 1 (CPT1), on day 30. …”
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5277por Mabasa, Lawrence, Kotze, Anri, Shabalala, Samukelisiwe, Kimani, Clare, Gabuza, Kwazi, Johnson, Rabia, Sangweni, Nonhlakanipho F., Maharaj, Vinesh, Muller, Christo J. F.“…The reduced lipid accumulation was associated with low expression of fatty acid synthase (Cpt1; p ≤ 0.05) and an upregulation of the fatty acid oxidation gene, carnitine palmitoyltransferase (Cpt1; p ≤ 0.01), as compared with the obese control mice. …”
Publicado 2022
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5278por Huang, Qiong-Hui, Wu, Xue, Chen, Xiao-Hong, Wu, Jia-Zhen, Su, Zi-Ren, Liang, Jia-Li, Li, Yu-Cui, Lai, Xiao-Ping, Chen, Jian-Nan, Liu, Yu-Hong“…What's more, PO pretreatment could also accelerate lipometabolism via up-regulating expressions of adenosine monophosphate-activated protein kinase (AMPK), peroxisome proliferator-activated receptor α (PPAR-α), and carnitine palmitoyltransferase 1 (CPT-1) and down-regulating expressions of nuclear factor-kappaB (NF-κB) p65, sterol regulatory element-binding protein 1 (SREBP-1c), fatty acid synthase (FAS), and stearoyl-CoA desaturase 1 (SCD-1). …”
Publicado 2018
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5279“…It was found that male infertility is closely related to disturbed phospholipid metabolism, amino acid metabolism, steroid hormone biosynthesis metabolism, metabolism of fatty acids and products of carnitine acylation, and purine and pyrimidine metabolisms. …”
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5280por Bernhardt, Isaac, Glamuzina, Emma, Dowsett, Leah K., Webster, Dianne, Knoll, Detlef, Carpenter, Kevin, Bennett, Michael J., Maeda, Michelle, Wilson, Callum“…Carnitine palmitoyltransferase 1A (CPT1A) deficiency is a long chain fatty acid oxidation disorder, typically presenting with hypoketotic hypoglycaemia and liver dysfunction during fasting and intercurrent illness. …”
Publicado 2022
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