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5321por Jin, Min, Monroig, Óscar, Lu, You, Yuan, Ye, Li, Yi, Ding, Liyun, Tocher, Douglas R., Zhou, Qicun“…Expression of acetyl-CoA carboxylase alpha (accα) and carnitine palmitoyl transferase 1A (cpt1a) were up-regulated by high DHA/EPA ratio, whereas sterol regulatory element-binding protein-1 (srebp-1) and hormone-sensitive lipase (hsl) were down-regulated. …”
Publicado 2017
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5322por Strand, Elin, Pedersen, Eva R., Svingen, Gard F. T., Olsen, Thomas, Bjørndal, Bodil, Karlsson, Therese, Dierkes, Jutta, Njølstad, Pål R., Mellgren, Gunnar, Tell, Grethe S., Berge, Rolf K., Svardal, Asbjørn, Nygård, Ottar“…Higher levels of the even‐chained acetyl‐, octanoyl‐, and palmitoyl‐carnitines were significantly associated with elevated risk of cardiovascular death, also after multivariable adjustments (HR [95% CI]: 1.52 [1.12, 2.06]; P=0.007; 1.73 [1.23, 2.44]; P=0.002; and 1.61 [1.18, 2.21]; P=0.003, respectively), whereas their associations with acute myocardial infarction were less consistent. …”
Publicado 2017
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5323por Koronowski, Kevin B., Khoury, Nathalie, Morris-Blanco, Kahlilia C., Stradecki-Cohan, Holly M., Garrett, Timothy J., Perez-Pinzon, Miguel A.“…Additionally, perturbations in β-oxidation and carnitine transferase (pentadecanoic acid, heptadecanoic acid) and glutamate transport and glutamine synthetase (urea, xylitol, adenine, adenosine, glycine, glutamic acid) were predicted. …”
Publicado 2018
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5324“…A doxycycline-inducible breast cancer cell line model overexpressing the rate-limiting enzyme in FAO, carnitine palmitoyl transferase 1A (CPT1A) was generated and analysed to confirm the association between FAO and cancer-associated characteristics in vitro. …”
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5325por Thapa, Khampaseuth, Wu, Kai Connie, Sarma, Aishwarya, Grund, Eric M., Szeto, Angela, Mendez, Armando J., Gesta, Stephane, Vishnudas, Vivek K., Narain, Niven R., Sarangarajan, Rangaprasad“…In this study human cardiomyocytes were exposed to an environmental nutritional perturbation of high glucose, fatty acids, and l-carnitine to model DCM and iTRAQ-coupled LC–MS/MS proteomic analysis was used to capture proteins affected by the perturbation. …”
Publicado 2018
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5326por Jung, Tae Woo, Lee, Sung Hoon, Kim, Hyoung-Chun, Bang, Joon Seok, Abd El-Aty, A. M., Hacımüftüoğlu, Ahmet, Shin, Yong Kyoo, Jeong, Ji Hoon“…Moreover, METRNL augmented the mRNA expression of fatty acid oxidation-associated genes, such as carnitine palmitoyltransferase 1 (CPT1), acyl-CoA oxidase (ACO), and fatty acid binding protein 3 (FABP3). siRNAs for AMPK and PPARδ reversed these changes. …”
Publicado 2018
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5327“…Finally, SCLE increased carnitine palmitoyltransferase 1 and acyl-CoA oxidase activities, which further promoted fatty acid β-oxidation. …”
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5328“…In rabbit liver, PB2 prevented the upregulation of steroid response element binding protein 1c and fatty acid synthase and the downregulation of carnitine palmitoyltransferase, compared to the HCD group. …”
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5329por Zeaiter, Zahraa, Marasco, Ramona, Booth, Jenny M., Prosdocimi, Erica M., Mapelli, Francesca, Callegari, Matteo, Fusi, Marco, Michoud, Grégoire, Molinari, Francesco, Daffonchio, Daniele, Borin, Sara, Crotti, Elena“…The genome presented compatible solute-based osmoadaptation traits, including genes encoding for osmotically activated glycine-betaine/carnitine/choline ABC transporters, as well as ectoine synthase enzymes. …”
Publicado 2019
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5330por Fang, Ke, Wu, Fan, Chen, Guang, Dong, Hui, Li, Jingbin, Zhao, Yan, Xu, Lijun, Zou, Xin, Lu, Fuer“…DSG treatment upregulated expression of lipolysis proteins, including phospho-AMP activated protein kinase (p-AMPK), phospho-acetyl-coA carboxylase (p-ACC) and carnitine acyl transferase 1A (CPT-1A), and inhibited expression of lipid synthesis-related proteins, including sterol regulatory element-binding protein 1c (SREBP-1c) and fatty acid synthase (FAS). …”
Publicado 2019
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5331por Mørkholt, Anne Skøttrup, Trabjerg, Michael Sloth, Oklinski, Michal Krystian Egelund, Bolther, Luise, Kroese, Lona John, Pritchard, Colin Eliot Jason, Huijbers, Ivo Johan, Nieland, John Dirk Vestergaard“…Human mutations in carnitine palmitoyl transferase 1A (CPT1A) are correlated with a remarkably low prevalence of multiple sclerosis (MS) in Inuits (P479L) and Hutterites (G710E). …”
Publicado 2019
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5332por Li, Yiping, Ruan, Xiaofen, Xu, Xiaowen, Li, Cha, Qiang, Tingting, Zhou, Hua, Gao, Junjie, Wang, Xiaolong“…The expression levels of free fatty acid oxidation [carnitine palmitoyltransferase-1 (CPT-1)], glucose oxidation [glucose transporter-4 (GLUT-4)], and mitochondrial biogenesis-related genes (peroxisome proliferator-activated receptor-γ coactivator-1α [PGC-1α]) were upregulated after SMI treatment. …”
Publicado 2019
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5333por Liu, Ting, Luo, Xin, Li, Zheng-Hong, Wu, Jun-Cheng, Luo, Sheng-Zheng, Xu, Ming-Yi“…AZGP1 knockdown was found to activate inflammation; enhance steatogenesis, including promoting lipogenesis [sterol regulatory element-binding protein (SREBP)-1c, liver X receptor (LXR), fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC), and stearoyl CoA desaturase 1 (SCD)-1], increasing lipid transport and accumulation [fatty acid transport protein (FATP), carnitine palmitoyl transferase (CPT)-1A, and adiponectin], and reducing fatty acid β-oxidation [farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor (PPAR)-α]; accelerate proliferation; and reverse apoptosis in LO2 cells. …”
Publicado 2019
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5334por Hunter-Manseau, Florence, Desrosiers, Véronique, Le François, Nathalie R., Dufresne, France, Detrich, H. William, Nozais, Christian, Blier, Pierre U.“…We measured the activity of four enzymes that control substrate entrance into the tricarboxylic acid (TCA) cycle: pyruvate kinase (PK), pyruvate dehydrogenase complex (PDHc), carnitine palmitoyltransferase (CPT), and hydroxyacyl-CoA dehydrogenase (HOAD). …”
Publicado 2019
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5335por Guevara-Cruz, Martha, Godinez-Salas, Einar T, Sanchez-Tapia, Monica, Torres-Villalobos, Gonzalo, Pichardo-Ontiveros, Edgar, Guizar-Heredia, Rocio, Arteaga-Sanchez, Liliana, Gamba, Gerardo, Mojica-Espinosa, Raul, Schcolnik-Cabrera, Alejandro, Granados, Omar, López-Barradas, Adriana, Vargas-Castillo, Ariana, Torre-Villalvazo, Ivan, Noriega, Lilia G, Torres, Nimbe, Tovar, Armando R“…As a result, there was an increase in circulating metabolites of β-oxidation and ω-oxidation, acyl-carnitines and ketone bodies. CONCLUSIONS: Change in the gut microbiota was accompanied by an improvement in insulin resistance and an increase in skeletal muscle fatty acid oxidation. …”
Publicado 2020
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5336por Choi, Doo Jin, Kim, Seong Cheol, Park, Gi Eun, Choi, Bo-Ram, Lee, Dae Young, Lee, Young-Seob, Park, Sung-Bum, Park, Yong Il, Kim, Geum Soog“…Furthermore, as compared to the mice fed HFD alone, ALM16 increased the levels of phosphorylated AMP-activated protein kinase (p-AMPK) and acetyl-CoA carboxylase (p-ACC), thereby upregulating the expression of carnitine palmitoyltransferase (CPT)-1 and downregulating the expression of sterol regulatory element-binding protein (SREBP)-1c and fatty acid synthase (FAS). …”
Publicado 2020
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5337“…Mechanistically, HCP5 sequestered miR-3619-5p and upregulated PPARG coactivator 1 alpha (PPARGC1A), increasing transcription complex Peroxisome proliferator activated receptor (PPAR) coactivator‐1α (PGC1α)/CEBPB and transcriptionally inducing carnitine palmitoyltransferase 1 (CPT1), which prompted the fatty acid oxidation (FAO) in GC cells. …”
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5338por Li, Qiuhua, Lai, Xingfei, Sun, Lingli, Cao, Junxi, Ling, Caijin, Zhang, Wenji, Xiang, Limin, Chen, Ruohong, Li, Dongli, Sun, Shili“…In addition, HT treatment also increased the phosphorylation of AMP-activated protein kinase (AMPK) and its direct downstream proteins, acetyl coenzyme A carboxylase (ACC), and carnitine palmitoyltransferase I (CPT-1), which participate in FAS pathway. …”
Publicado 2020
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5339por Musumeci, Olimpia, Ferlazzo, Edoardo, Rodolico, Carmelo, Gambardella, Antonio, Gagliardi, Monica, Aguglia, Umberto, Toscano, Antonio“…Increased plasma C14:1-carnitine levels and the identification of two known heterozygous mutations c. 553G>A (p.G185S) and c.1153C>T (p.R385W) in ACADVL confirmed the additional diagnosis of VLCAD deficiency in the proband. …”
Publicado 2020
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5340por Li, Jie, Minćzuk, Krzysztof, Massey, James C., Howell, Nancy L., Roy, R. Jack, Paul, Soumen, Patrie, James T., Kramer, Christopher M., Epstein, Frederick H., Carey, Robert M., Taegtmeyer, Heinrich, Keller, Susanna R., Kundu, Bijoy K.“…Cardiac metabolite profiling demonstrated that metformin decreased fatty acyl carnitines and markers of oxidative stress in SHR. CONCLUSIONS: Metformin reduced blood pressure, normalized myocardial glucose uptake, prevented left ventricular hypertrophy, and improved cardiac function in SHR. …”
Publicado 2020
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