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5341Lack of association between modifiable exposures and glioma risk: a Mendelian randomization analysispor Saunders, Charlie N, Cornish, Alex J, Kinnersley, Ben, Law, Philip J, Claus, Elizabeth B, Il’yasova, Dora, Schildkraut, Joellen, Barnholtz-Sloan, Jill S, Olson, Sara H, Bernstein, Jonine L, Lai, Rose K, Chanock, Stephen, Rajaraman, Preetha, Johansen, Christoffer, Jenkins, Robert B, Melin, Beatrice S, Wrensch, Margaret R, Sanson, Marc, Bondy, Melissa L, Houlston, Richard S“…We used the estimated odds ratio of glioma associated with each of the genetically defined traits to infer evidence for a causal relationship with the following exposures: Lifestyle and dietary factors—height, plasma insulin-like growth factor 1, blood carnitine, blood methionine, blood selenium, blood zinc, circulating adiponectin, circulating carotenoids, iron status, serum calcium, vitamins (A1, B12, B6, E, and 25-hydroxyvitamin D), fatty acid levels (monounsaturated, omega-3, and omega-6) and circulating fetuin-A; Cardiometabolic factors—birth weight, high density lipoprotein cholesterol, low density lipoprotein cholesterol, total cholesterol, total triglycerides, basal metabolic rate, body fat percentage, body mass index, fasting glucose, fasting proinsulin, glycated hemoglobin levels, diastolic and systolic blood pressure, waist circumference, waist-to-hip ratio; and Inflammatory factors— C-reactive protein, plasma interleukin-6 receptor subunit alpha and serum immunoglobulin E. …”
Publicado 2020
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5342“…Data were analysed using different data mining approaches. RESULTS: Carnitine, acetylcarnitine, propionoylcarnitine, amino acid related compounds cis-4-hydroxyproline, trans-4-hydroxyproline, proline betaine, lysophosphatidylcholine PC a C16:1 and phosphatidylcholine PC ae C36:0 were identified as the key metabolites distinguishing MP from PP cows. …”
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5343por Thompson, Elizabeth A., Cascino, Katherine, Ordonez, Alvaro A., Zhou, Weiqiang, Vaghasia, Ajay, Hamacher-Brady, Anne, Brady, Nathan R., Sun, Im-Hong, Wang, Rulin, Rosenberg, Avi Z., Delannoy, Michael, Rothman, Richard, Fenstermacher, Katherine, Sauer, Lauren, Shaw-Saliba, Kathyrn, Bloch, Evan M., Redd, Andrew D., Tobian, Aaron AR, Horton, Maureen, Smith, Kellie, Pekosz, Andrew, D’Alessio, Franco R., Yegnasubramanian, Srinivasan, Ji, Hongkai, Cox, Andrea L., Powell, Jonathan D.“…Finally, we revealed a unique population of monocytic MDSC (M-MDSC) expressing high levels of carnitine palmitoyltransferase 1a (CPT1a) and VDAC. …”
Publicado 2020
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5344por Dutta, Anirban, Karanth, Sneha Sudhakar, Bhattacharya, Mahasweta, Liput, Michal, Augustyniak, Justyna, Cheung, Mancheung, Stachowiak, Ewa K., Stachowiak, Michal K.“…Also, a significant effect of drugs, choline (CHO), idebenone (IDB), R-alpha-lipoic acid plus acetyl-l-carnitine (LCLA), was found on the CCO activity (chi-square (3, N = 10) = 25.44, p = 1.2492e−05), spectral exponent between 1 and 20 Hz (chi-square (3, N = 16) = 43.5, p = 1.9273e−09) and 30–50 Hz (chi-square (3, N = 16) = 23.47, p = 3.2148e−05) in 34 days old CO from schizophrenia (SCZ) patients iPSC. …”
Publicado 2020
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5345por Kamboj, Parul, Sarkar, Soumalya, Gupta, Sonu Kumar, Bisht, Neema, Kumari, Deepika, Alam, Md. Jahangir, Barge, Sagar, Kashyap, Bhaswati, Deka, Barsha, Bharadwaj, Simanta, Rahman, Seydur, Dutta, Partha Pratim, Borah, Jagat C., Talukdar, Narayan Chandra, Banerjee, Sanjay K., Kumar, Yashwant“…Different group of metabolites mainly bile acids, fatty acids, carnitines, and their derivatives were found to be altered in the diseased rats. …”
Publicado 2021
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5346por Peng, Shaoyong, Chen, Daici, Cai, Jian, Yuan, Zixu, Huang, Binjie, Li, Yichen, Wang, Huaiming, Luo, Qianxin, Kuang, Yingyi, Liang, Wenfeng, Liu, Zhihang, Wang, Qian, Cui, Yanmei, Wang, Hui, Liu, Xiaoxia“…Furthermore, we confirmed that carnitine palmitoyltransferase IA (CPT1A), a rate‐limiting enzyme of FAO, was expressed at significantly low levels in patients with PM colorectal cancer, as determined by RT‐qPCR, IHC, and GEO dataset analysis. …”
Publicado 2021
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5347por Feng, Li Rebekah, Barb, Jennifer J., Allen, Hannah, Regan, Jeniece, Saligan, Leorey“…Additional overrepresented metabolic pathways included amino acid metabolism, glutathione metabolism, and carnitine synthesis. Of the metabolites that were significantly different between the groups, steroid hormone biosynthesis metabolites were most significantly correlated with fatigue severity. …”
Publicado 2021
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5348por Luan, Hemi, Gu, Wanjian, Li, Hua, Wang, Zi, Lu, Lu, Ke, Mengying, Lu, Jiawei, Chen, Wenjun, Lan, Zhangzhang, Xiao, Yanlin, Xu, Jinyue, Zhang, Yi, Cai, Zongwei, Liu, Shijia, Zhang, Wenyong“…A co-occurrence network using serum omics profiles was built and parsed into six modules, showing significant association between the inflammation and immune activity markers and aberrant metabolism of energy metabolism, lipids metabolism and amino acid metabolism. Acyl carnitines (20:3), aspartyl-phenylalanine, pipecolic acid, phosphatidylethanolamine PE (18:1) and lysophosphatidylethanolamine LPE (20:3) were positively correlated with the RA disease activity, while histidine and phosphatidic acid PA (28:0) were negatively correlated with the RA disease activity. …”
Publicado 2021
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5349por Rebollo-Hernanz, Miguel, Aguilera, Yolanda, Martín-Cabrejas, Maria A., Gonzalez de Mejia, Elvira“…Coffee by-products' bioactive compounds decreased lipid accumulation (23–41%) and fatty acid synthase activity (32–65%) and triggered carnitine palmitoyltransferase-1 activity (1.3 to 1.7-fold) by activating AMPK and SREBP-1c pathways. …”
Publicado 2022
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5350por Gao, Yongyao, Jiang, Xiaomeng, Yang, Daigang, Guo, Wentong, Wang, Dandan, Gong, Ke, Peng, Ying, Jiang, Hong, Shi, Cunyuan, Duan, Yajun, Chen, Yuanli, Han, Jihong, Yang, Xiaoxiao“…Roxadustat-reduced fatty liver was mainly contributed by the reducing sterol-responsive element-binding protein 1c (SREBP1c) pathway, and enhancing β-oxidation through inducing peroxisome proliferator-activated receptor α (PPARα) and carnitine palmitoyltransferase 1A (CPT1A) expression. …”
Publicado 2022
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5351por Bjørnestad, Espen Ø, Dhar, Indu, Svingen, Gard F T, Pedersen, Eva R, Svenningsson, Mads M, Tell, Grethe S, Ueland, Per M, Ørn, Stein, Sulo, Gerhard, Laaksonen, Reijo, Nygård, Ottar“…AIMS: Trimethyllysine (TML) is involved in carnitine synthesis, serves as a precursor of trimethylamine N-oxide (TMAO) and is associated with cardiovascular events in patients with established coronary heart disease (CHD). …”
Publicado 2021
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5352por Veenvliet, Annemarijne R.J., Garrelfs, Mark R., Udink ten Cate, Floris E.A., Ferdinandusse, Sacha, Denis, Simone, Fuchs, Sabine A., Schwantje, Marit, Geurtzen, Rosa, van Wegberg, Annemiek M.J., Huigen, Marleen C.D.G., Kluijtmans, Leo A.J., Wanders, Ronald J.A., Derks, Terry G.J., de Boer, Lonneke, Houtkooper, Riekelt H., de Vries, Maaike C., van Karnebeek, Clara D.M.“…Subsequent treatment with special low-fat formula, low in long chain triglycerides (LCT) and supplemented with medium chain triglycerides (MCT) and ketone body therapy in (sodium-D,L-3-hydroxybutyrate) was well tolerated and resulted in improved carnitine profiles and cardiac function. Resveratrol, a natural polyphenol that has been shown to increase fatty acid oxidation, was also considered as a potential treatment option but showed no in vitro benefits in the patient's fibroblasts. …”
Publicado 2022
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5353por Tummolo, Albina, Leone, Piero, Tolomeo, Maria, Solito, Rita, Mattiuzzo, Matteo, Lepri, Francesca Romana, Lorè, Tania, Cardinali, Roberta, De Giovanni, Donatella, Simonetti, Simonetta, Barile, Maria“…The patient's clinical picture improved after supplementation of Rf, l‐carnitine, Coenzyme Q10, and also 3OH‐butyrate. This report demonstrates that, even in the absence of genetic defects in genes involved in Rf homeostasis, further targeted molecular analysis may reveal secondary and possibly treatable biochemical alterations in this pattern.…”
Publicado 2022
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5354por Li, Weihui, Wang, Wei, He, Xin, Liao, Zheng, Aierken, Aili, Hua, Jinlian, Wang, Yan, Lu, Dezhang, Zhang, Shiqiang“…Furthermore, UHPLC-MS/MS analysis also revealed six metabolites (carnitine, melibiose, d-Glucosamine, cytidine, dihydroorotic acid, stachyose) in plasma were highly correlated with the dynamic process of PR-AKI on cats. …”
Publicado 2022
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5355por Chen, Chen, Zhao, Wei, Lu, Xingxing, Ma, Yunbo, Zhang, Peizhi, Wang, Zicheng, Cui, Zilian, Xia, Qinghua“…AUP1 also induced lipid accumulation in ccRCC by promoting the de novo synthesis of FAs (inhibiting protein kinase AMP‐activated catalytic subunit alpha 2), inhibiting the rate‐limiting enzyme of FA β oxidation (carnitine palmitoyltransferase 1A), regulating the key enzyme of lipolysis (monoglyceride lipase, MGLL), and inhibiting the lipid transporter StAR‐related lipid transfer domain containing 5 (STARD5). …”
Publicado 2022
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5356por Qu, Xiaoye, Wen, Yankai, Jiao, Junzhe, Zhao, Jie, Sun, Xuehua, Wang, Fang, Gao, Yueqiu, Tan, Weifeng, Xia, Qiang, Wu, Hailong, Kong, Xiaoni“…PPARa, a key regulator of β‐oxidation, and carnitine palmitoyltransferase 1a (CPT1a), a rate‐limiting enzyme of β‐oxidation, had substantially decreased expression in the regenerating liver of Park7 (△hep) mice. …”
Publicado 2022
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5357“…There is a growing interest in the role of lipid metabolism in cancer. Carnitine palmitoyl-transferase-1 (CPT-1); the rate limiting step in fatty acid oxidation, has been shown to be overexpressed in a range of tumours. …”
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5358por Niu, Hao, Atallah, Edmond, Alvarez-Alvarez, Ismael, Medina-Caliz, Inmaculada, Aithal, Guruprasad P., Arikan, Cigdem, Andrade, Raul J., Lucena, M. Isabel“…N-acetylcysteine (n = 14), ursodeoxycholic acid (n = 3), corticosteroids (n = 31), carnitine (n = 16) and the combination of glycyrrhizin, reduced glutathione, polyene phosphatidylcholine and S-adenosylmethionine (n = 31) were the therapeutic options for treating idiosyncratic DILI. …”
Publicado 2022
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5359por Yin, Xianyong, Bose, Debraj, Kwon, Annie, Hanks, Sarah C., Jackson, Anne U., Stringham, Heather M., Welch, Ryan, Oravilahti, Anniina, Fernandes Silva, Lilian, Locke, Adam E., Fuchsberger, Christian, Service, Susan K., Erdos, Michael R., Bonnycastle, Lori L., Kuusisto, Johanna, Stitziel, Nathan O., Hall, Ira M., Morrison, Jean, Ripatti, Samuli, Palotie, Aarno, Freimer, Nelson B., Collins, Francis S., Mohlke, Karen L., Scott, Laura J., Fauman, Eric B., Burant, Charles, Boehnke, Michael, Laakso, Markku, Wen, Xiaoquan“…We identified putative causal effects of UGT1A1/UGT1A4 expression on gallbladder disorders through regulating plasma (E,E)-bilirubin levels, of SLC22A5 expression on nasal polyps and plasma carnitine levels through distinct pathways, and of LIPC expression on age-related macular degeneration through glycerophospholipid metabolic pathways. …”
Publicado 2022
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5360por Wang, Rui, Zhao, Jun, Jin, Jiacheng, Tian, Yun, Lan, Lan, Wang, Xuejian, Zhu, Liang, Wang, Jianbo“…A theoretical functional mechanism was proposed in ccRCC: WY-14,643 mediates lipid consumption by recognizing carnitine palmitoyltransferase 1 A (CPT1A). Activation of PPARα using WY-14,643 reduces lipid deposition by increasing the CPT1A level, which also suppresses the NF-κB signaling pathway. …”
Publicado 2022
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