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5401por Tan, Jijun, Hu, Ruizhi, Gong, Jiatai, Fang, Chengkun, Li, Yanli, Liu, Ming, He, Ziyu, Hou, De-Xing, Zhang, Hongfu, He, Jianhua, Wu, Shusong“…FMT experiments showed that Enterococcus faecalis caused hepatic inflammation, fat deposition and insulin resistance with decreased expression of carnitine palmitoyltransferase-1 alpha (CPT1α), which can be reversed by PCA through inhibiting Enterococcus faecalis. …”
Publicado 2023
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5402por Qiu, Jiewen, Wei, Lijian, Su, Yilin, Tang, Yuting, Peng, Guoyou, Wu, Yimin, He, Yan, Liu, Hanqun, Guo, Wenyuan, Wu, Zhuohu, Xu, Pingyi, Mo, Mingshu“…A total of 12 lipid species, including 3-hydroxy-dodecanoyl-carnitine, Cer(d18:1/24:1), CE(20:4), CE(22:6), PC(14:0/18:2), PC(O-18:3/20:2), PC(O-20:2/24:3), SM(d18:0/16:0), SM(d18:2/14:0), SM(d18:2/24:1), SM(d18:1/20:1) and SM(d18:1/12:0), were selected to draw the lipidomic signature of PD. …”
Publicado 2023
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5403por Wu, Mingxin, Du, Yufei, Zhang, Chi, Li, Zhen, Li, Qingyang, Qi, Enlin, Ruan, Wendong, Feng, Shiqing, Zhou, Hengxing“…Lipid metabolism, which includes processes such as fatty acid metabolism, glycerol metabolism, inositol metabolism, bile acid metabolism, carnitine metabolism, ketone body metabolism, sterol and steroid metabolism, etc., may have an impact on changes in bone mineral density. …”
Publicado 2023
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5404por Belenkov, Yuri N., Ageev, Anton A., Kozhevnikova, Maria V., Khabarova, Natalia V., Krivova, Anastasia V., Korobkova, Ekaterina O., Popova, Ludmila V., Emelyanov, Alexey V., Appolonova, Svetlana A., Moskaleva, Natalia E., Shestakova, Ksenia M., Privalova, Elena V.“…However, a decrease in levels compared to referent values of ACs with medium and long chain lengths was 50% of the CHF-CHD cohort. Carnitine deficiency was found in 6% and acylcarnitine deficiency in 3% of all patients with chronic heart disease. …”
Publicado 2023
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5405por Liu, Tiantian, Chen, Xinlu, Wei, Ziqi, Han, Xue, Liu, Yujia, Ma, Zhengliang, Xia, Tianjiao, Gu, Xiaoping“…RESULTS: Our results showed that 6 h long-term isoflurane anesthesia induced contextual memory damage in mice, accompanied by decreases of fatty acid oxidation-related proteins (peroxisome proliferator-activated receptor γ coactivator 1α, carnitine palmitoyltransferase 1A, and PPARα) both in the hippocampus of POCD mice and in N2a cells. …”
Publicado 2023
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5406por Al Jadani, Jwharah M., Albadr, Nawal A., Alshammari, Ghedeir M., Almasri, Soheir A., Alfayez, Farah Fayez, Yahya, Mohammed Abdo“…In addition, it improved the liver structure, attenuating the increase in fat vacuoles; reduced levels of TGs and CHOL, and the mRNA levels of SREBP1 and acetyl CoA carboxylase (ACC); and upregulated the mRNA levels of proliferator-activated receptor α (PPARα) and carnitine palmitoyltransferase I (CPT I) in HFD-fed rats. …”
Publicado 2023
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5407por Zhang, Qianjin, Gong, Jiatai, Xiang, Hongkun, Hu, Ruizhi, Yang, Xizi, Lv, Jing, Zhang, Wentao, Liu, Ming, Deng, Xiong, Yuan, Xupeng, He, Ziyu, Jiang, Yixuan, Tan, Bie, He, Jianhua, Wu, Shusong“…Correlation analysis showed that g-UCG-005 was positively correlated with the expression of FAS, carnitine palmitoyl transferase 1B (CPT1B), SREBP1c and PPARγ (P < 0.01). …”
Publicado 2023
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5408Publicado 1976“…The time course of increase in catalase and carnitine acetyltransferase activities correlated with the morphometric data on the peroxisomes. …”
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5409“…CONCLUSION: In addition to carnitine-acylcarnitine translocase (CACT) deficiency and Hermansky-Pudlak syndrome type 3, this represents only the third reported case in which 2 different splice mutations has resulted in an aberrant clinical phenotype.…”
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5410“…Body weight gain, adipose tissue weights, nitrogen balance, absorptions of energy, protein and fat, lipid profiles in plasma, liver and feces and hepatic activities of carnitine palmitoyl transferase (CPT), fatty acid synthase (FAS), malic enzyme (ME) and glucose-6-phosphate dehydrogenase (G6PDH) were assessed. …”
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5411por Hu, Xiao-Qian, Wang, Yu-Ming, Wang, Jing-Feng, Xue, Yong, Li, Zhao-Jie, Nagao, Koji, Yanagita, Teruyoshi, Xue, Chang-Hu“…Otherwise, the rats feeding with SSC showed increased carnitine palmitoyl transferase (CPT) activity in the liver. …”
Publicado 2010
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5412por Phillips, Tudor J. C., Cherry, Catherine L., Cox, Sarah, Marshall, Sarah J., Rice, Andrew S. C.“…No superiority over placebo was reported in RCTs that examined amitriptyline (100mg/day), gabapentin (2.4g/day), pregabalin (1200mg/day), prosaptide (16mg/day), peptide-T (6mg/day), acetyl-L-carnitine (1g/day), mexilitine (600mg/day), lamotrigine (600mg/day) and topical capsaicin (0.075% q.d.s.). …”
Publicado 2010
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5413por van der Kloet, F. M., Tempels, F. W. A., Ismail, N., van der Heijden, R., Kasper, P. T., Rojas-Cherto, M., van Doorn, R., Spijksma, G., Koek, M., van der Greef, J., Mäkinen, V. P., Forsblom, C., Holthöfer, H., Groop, P. H., Reijmers, T. H., Hankemeier, T.“…The discriminating metabolites included acyl-carnitines, acyl-glycines and metabolites related to tryptophan metabolism. …”
Publicado 2011
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5414por Jourdan, Carolin, Petersen, Ann-Kristin, Gieger, Christian, Döring, Angela, Illig, Thomas, Wang-Sattler, Rui, Meisinger, Christa, Peters, Annette, Adamski, Jerzy, Prehn, Cornelia, Suhre, Karsten, Altmaier, Elisabeth, Kastenmüller, Gabi, Römisch-Margl, Werner, Theis, Fabian J., Krumsiek, Jan, Wichmann, H.-Erich, Linseisen, Jakob“…Among the most prominent associations (p-values 4.75×10(−16)–8.95×10(−06)) with higher FFMI were increasing concentrations of the branched chained amino acids (BCAAs), ratios of BCAAs to glucogenic amino acids, and carnitine concentrations. For various PCs, a decrease in chain length or in saturation of the fatty acid moieties could be observed with increasing FFMI, as well as an overall shift from acyl-alkyl PCs to diacyl PCs. …”
Publicado 2012
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5415por Kumar, Nilay, Bashar, Qumseya, Reddy, Naveen, Sengupta, Jyotirmoy, Ananthakrishnan, Ashwin, Schroeder, Abigail, Hogan, Walter J, Venkatesan, Thangam“…The majority of patients (86%) responded to treatment with tricyclic antidepressants, anticonvulsants (topiramate), coenzyme Q-10, and L-carnitine. Non-response to therapy was associated with coalescence of symptoms, chronic opiate use and more severe disease as characterized by longer episodes, greater number of emergency department visits in the year prior to presentation, presence of disability and non-compliance on univariate analysis. …”
Publicado 2012
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5416por Outlaw, Jordan, Wilborn, Colin, Smith, Abbie, Urbina, Stacie, Hayward, Sara, Foster, Cliffa, Wells, Shawn, Wildman, Rob, Taylor, Lem“…METHODS: Six male and six female subjects (mean ± SD; 22.50 ± 3.22 years; 76.94 ± 14.78 kg; 22.7 ± 9.5% body fat), physically active (≥12 months), and moderate habitual caffeine consumers (<200 mg/day) received either two capsules of DBX containing 340 mg of total caffeine plus green tea extract, yerba mate extract, carnitine tartrate and other active ingredients or a placebo (PLC) in a double-blinded, crossover design. …”
Publicado 2013
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5417por Yamashita, Michiaki, Yamashita, Yumiko, Suzuki, Tamami, Kani, Yoko, Mizusawa, Nanami, Imamura, Shintaro, Takemoto, Kenji, Hara, Tatsuro, Hossain, Md. Anwar, Yabu, Takeshi, Touhata, Ken“…Here, we report evidence that selenoneine accelerates the excretion and demethylation of MeHg, mediated by a selenoneine-specific transporter, organic cations/carnitine transporter-1 (OCTN1). Selenoneine was incorporated into human embryonic kidney HEK293 cells transiently overexpressing OCTN1 and zebrafish blood cells by OCTN1. …”
Publicado 2013
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5418por Figarola, James Lester, Singhal, Preeti, Rahbar, Samuel, Gugiu, Bogdan Gabriel, Awasthi, Sanjay, Singhal, Sharad S.“…Western blots demonstrated increased AMPK activation in liver and adipose tissues of SR4-treated HFD obese mice, while gene analyses by real time PCR showed COH-SR4 significantly suppressed the mRNA expression of lipogenic genes such as sterol regulatory element binding protein-1c (Srebf1), acetyl-Coenzyme A carboxylase (Acaca), peroxisome proliferator-activated receptor gamma (Pparg), fatty acid synthase (Fasn), stearoyl-Coenzyme A desaturase 1 (Scd1), carnitine palmitoyltransferase 1a (Cpt1a) and 3-hydroxy-3-methyl-glutaryl-CoA reductase (Hmgcr), as well as gluconeogenic genes phosphoenolpyruvate carboxykinase 1 (Pck1) and glucose-6-phosphatase (G6pc) in the liver of obese mice. …”
Publicado 2013
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5419“…To unblock the β-oxidation pathway, the gene CROT, which encodes carnitine O-octanoyltransferase, was expressed in the Δpox1 [pox2+] strain to transport the accumulated medium chain acyl-coAs out of the peroxisomes. …”
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5420por Ishimoto, Takahiro, Nakamichi, Noritaka, Hosotani, Hiroshi, Masuo, Yusuke, Sugiura, Tomoko, Kato, Yukio“…The aim of the present study is to clarify the functional expression and physiological role in neural progenitor cells (NPCs) of carnitine/organic cation transporter OCTN1/SLC22A4, which accepts the naturally occurring food-derived antioxidant ergothioneine (ERGO) as a substrate in vivo. …”
Publicado 2014
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