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5421“…This study reveals novel findings such as the divergent expression of the fatty acid β-oxidation enzymes Acyl-CoA oxidase 1 and Carnitine palmitoyltransferase 1a, indicating a switch from mitochondrial to peroxisomal β-oxidation after weaning; as well as the dynamic ontogeny of genes implicated in obesity such as Stearoyl-CoA desaturase 1 and Elongation of very long chain fatty acids-like 3. …”
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5422por Ge, Xiaodong, Antoine, Daniel J., Lu, Yongke, Arriazu, Elena, Leung, Tung-Ming, Klepper, Arielle L., Branch, Andrea D., Fiel, Maria Isabel, Nieto, Natalia“…Selective ablation of Hmgb1 in hepatocytes protected mice from alcohol-induced liver injury due to increased carnitine palmitoyltransferase-1, phosphorylated 5′AMP-activated protein kinase-α, and phosphorylated peroxisome proliferator-activated receptor-α expression along with elevated LDL plus VLDL export. …”
Publicado 2014
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5423por Fujikawa, Takahiko, Hirata, Tetsuya, Hosoo, Shingo, Nakajima, Kenji, Wada, Atsunori, Yurugi, Yutaka, Soya, Hideaki, Matsui, Takashi, Yamaguchi, Akihiko, Ogata, Masato, Nishibe, Sansei“…RT–PCR studies showed that ASP (like ELE with known anti-obesity effects) diminished isocitrate dehydrogenase 3α, NADH dehydrogenase flavoprotein 1 (Comp I) mRNA and fatty acid synthase levels (white adipose tissue), increased carnitine palmitoyltransferase 1α and acyl-CoA dehydrogenase, very-long-chain mRNA levels (liver), and increased Glut4, citrate synthase, isocitrate dehydrogenase 3α, succinyl CoA synthase, peroxisomal 3-ketoacyl-CoA thiolase, dihydrolipoamide succinyl transferase and succinate dehydrogenase mRNA levels (skeletal muscle) under HFD conditions. …”
Publicado 2012
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5424por Le, Phong T., Pearce, Meghan M., Zhang, Shubin, Campbell, Edward M., Fok, Cynthia S., Mueller, Elizabeth R., Brincat, Cynthia A., Wolfe, Alan J., Brubaker, Linda“…The cultured HUCs expressed muscarinic receptors (MR1 and MR2), carnitine acetyltransferase (CarAT), immunoregulatory cytokines IL7, IL15, and IL23, as well as the chemokine CCL20. …”
Publicado 2014
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5425“…Results showed RNA for CarAT, carnitine/acylcarnitine translocase member 20 (Slc25a20), VAChT, OCTN2, OCT1, OCT3, organic cation transporter member 4 (Slc22a4), AChE, BChE, nAChR subunits α1, α2, α3, α5, α7, α10, β1, β2, β4, γ and mAChR subunits M1, M2, M3, M4, M5 were detected in rat’s maxilla. …”
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5426“…Despite the abundance of AMPAR partners, recent proteomic studies have revealed even more interacting proteins that could potentially be involved in AMPAR regulation. Amongst these, carnitine palmitoyltransferase 1C (CPT1C) has been demonstrated to form an integral part of native AMPAR complexes in brain tissue extracts. …”
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5427por Wang, Yong, Li, Chun, Wang, Qiyan, Shi, Tianjiao, Wang, Jing, Chen, Hui, Wu, Yan, Han, Jing, Guo, Shuzhen, Wang, Yuanyuan, Wang, Wei“…The Lipid transport pathway, fatty acids transport protein (FATP) and Carnitine palmitoyltransferase I (CPTI) were down-regulated in model group. …”
Publicado 2015
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5428“…Correspondingly, clofibrate increased fetal hepatic carnitine palmitoyltransferase (CPT) and acyl-CoA oxidase (ACO) activities by 36% and 42% over controls (P < 0.036). …”
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5429por Zhan, Yutao, Zhao, Fei, Xie, Ping, Zhong, Leping, Li, Dongnian, Gai, Qujing, Li, Li, Wei, Hongshan, Zhang, Lingqiang, An, Wei“…The expression levels of lipid metabolism-related key molecules, namely sterol regulatory element-binding protein-1c (SREBP-1c), stearoyl-coA desaturase (SCD), carnitine palmitoyltransferase-1 (CPT1) and microsomal triglyceride transfer protein (MTP), in HepG2 cells with abnormal GLT8D2 expression were determined by western blot analyses. …”
Publicado 2015
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5430“…FAS and sterol regulatory element-binding proteins 1 (SREBP1) mRNA gene expressions were increased (P<0.05) while the muscle-carnitine palmityl transferase (M-CPT) and peroxisome proliferators-activated receptorγ (PPARγ) mRNA (P<0.05) gene expressions were decreased in the muscles of the IUGR pigs by choline supplementation. …”
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5431“…Exposure to cold temperature enhanced plasma glucose, triglyceride and free FA levels, monounsaturation of FAs, mitochondrial enzymes activities (cytochrome c oxidase and carnitine palmitoyltransferase; U/g liver), with the upregulation of the genes involved in glycogenolysis (pygl), gluconeogenesis (pck1 and g6pc2), FA β-oxidation (acadl), and cholesterol uptake and synthesis (hmgcr, srebp2 and ldlr1), glycerophospholipids synthesis (pcyt1, pcyt2, pemt, and pparg), and FA monounsaturation (scd1) and chain elongation (elovl1 and elovl2). …”
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5432por Hall, Jean A., MacLeay, Jennifer, Yerramilli, Maha, Obare, Edward, Yerramilli, Murthy, Schiefelbein, Heidi, Paetau-Robinson, Inke, Jewell, Dennis E.“…Test food contained functional lipids (fish oil), antioxidants (vitamins C and E), L-carnitine, botanicals (vegetables), highly bioavailable protein, and amino acid supplements. …”
Publicado 2016
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5433“…RESULTS: The most outstanding results were those obtained for the expression of the lipolytic gene carnitine palmitoyltransferase 1a (Cpt1a). Cpt1a expression in PBMC increased after only 1 month of exposure to both unbalanced diets, and this increased expression was maintained thereafter. …”
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5434por Dubey, Amit K., Barad, Shiri, Luria, Neta, Kumar, Dilip, Espeso, Eduardo A., Prusky, Dov B.“…Inhibition of appressorium formation in ΔsltA mutants was accompanied by downregulation of the MAP kinase pmk1 and carnitine acetyl transferase (cat1), genes involved in appressorium formation and colonization, which was restored by Ca(2+) supplementation. …”
Publicado 2016
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5435“…Acyl-CoA dehydrogenase 9 (ACAD9), linked to chromosome 3q21.3, is one of a family of multimeric mitochondrial flavoenzymes that catalyze the degradation of fatty acyl-CoA from the carnitine shuttle via β-oxidation (He et al. 2007). …”
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5436por Qian, Jianchang, Chen, Yaqing, Meng, Tao, Ma, Lanping, Meng, Lanfang, Wang, Xin, Yu, Ting, Zask, Arie, Shen, Jingkang, Yu, Ker“…We also found that the basal levels of carnitine palmitoyltransferase 1A and lipid catabolism were elevated in HER2+/PIK3CAmut breast cells and were inhibited upon mTOR-KI treatment. …”
Publicado 2016
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5437por Puhka, Maija, Takatalo, Maarit, Nordberg, Maria-Elisa, Valkonen, Sami, Nandania, Jatin, Aatonen, Maria, Yliperttula, Marjo, Laitinen, Saara, Velagapudi, Vidya, Mirtti, Tuomas, Kallioniemi, Olli, Rannikko, Antti, Siljander, Pia R-M, af Hällström, Taija Maria“…Analysis of the urinary EVs from the patients indicated that the levels of glucuronate, D-ribose 5-phosphate and isobutyryl-L-carnitine were 2-26-fold lower in all pre-prostatectomy samples compared to the healthy control and post-prostatectomy samples (p < 0.05). …”
Publicado 2017
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5438“…Carnitine palmitoyltransferase I (CPT I) is a key enzyme involved in the regulation of lipid metabolism and fatty acid β-oxidation. …”
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5439“…TG-specific lipolytic genes [carnitine palmitoyltransferase 1A (CPT1A) and solute-carrier family 27A (SLC27A)] among these showed significant increase in their expression levels. …”
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5440por Jahansouz, Cyrus, Xu, Hongliang, Hertzel, Ann V., Kizy, Scott S., Steen, Kaylee A., Foncea, Rocio, Serrot, Federico J., Kvalheim, Nicholas, Luthra, Girish, Ewing, Kristin, Leslie, Daniel B., Ikramuddin, Sayeed, Bernlohr, David A.“…This unique metabolic alteration leads to changes in downstream PPARγ/δ targets including decreased expression of FABP4 and SCD1 with increased expression of carnitine palmitoyl transferase 1 (CPT1) and uncoupling protein 2 (UCP2). …”
Publicado 2017
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