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5441por Yamada, Kenji, Shiraishi, Hideaki, Oki, Eishin, Ishige, Mika, Fukao, Toshiyuki, Hamada, Yusuke, Sakai, Norio, Ochi, Fumihiro, Watanabe, Asami, Kawakami, Sanae, Kuzume, Kazuyo, Watanabe, Kenji, Sameshima, Koji, Nakamagoe, Kiyotaka, Tamaoka, Akira, Asahina, Naoko, Yokoshiki, Saki, Miyakoshi, Takashi, Ono, Kota, Oba, Koji, Isoe, Toshiyuki, Hayashi, Hiroshi, Yamaguchi, Seiji, Sato, Norihiro“…MATERIALS AND METHODS: This trial was an open-label, non-randomized, and multicenter study of bezafibrate treatment in 6 patients with very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency and 2 patients with carnitine palmitoyltransferase-II (CPT-2) deficiency (median age, 8.2 years; ranging from 5.8 to 26.4 years). …”
Publicado 2018
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5442por Olek, Robert A., Kujach, Sylwester, Ziemann, Ewa, Ziolkowski, Wieslaw, Waz, Piotr, Laskowski, Radoslaw“…In the muscle samples maximal activities of citrate synthase (CS), 3-hydroxyacylCoA dehydrogenase (HADH), carnitine palmitoyl-transferase (CPT), malate dehydrogenase (MDH), and its mitochondrial form (mMDH), as well as lactate dehydrogenase (LDH) were determined. …”
Publicado 2018
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5443por Jiao, A. R., Diao, H., Yu, B., He, J., Yu, J., Zheng, P., Huang, Z. Q., Luo, Y. H., Luo, J. Q., Mao, X. B., Chen, D. W.“…In addition, SCFAs down-regulated the mRNA expressions of fatty acid synthase (FAS) and sterol regulatory element binding protein 1c (P<0.05), and enhanced the mRNA expression of carnitine palmitoyltransferase-1α (CPT-1α) in liver (P<0.05). …”
Publicado 2018
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5444“…In Exp. 3, primary oocytes of P. fulvidraco were treated with (R)-(+)-etomoxir (an inhibitor of β-oxidation) or l-carnitine (an enhancer of β-oxidation) for 48 h under rt-hLEP incubation. …”
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5445por Ronowska, Anna, Szutowicz, Andrzej, Bielarczyk, Hanna, Gul-Hinc, Sylwia, Klimaszewska-Łata, Joanna, Dyś, Aleksandra, Zyśk, Marlena, Jankowska-Kulawy, Agnieszka“…They appear to be from 2 to 20 times lower than acetyl-CoA Km values for carnitine acetyltransferase, acetyl-CoA carboxylase, aspartate acetyltransferase, choline acetyltransferase, sphingosine kinase 1 acetyltransferase, acetyl-CoA hydrolase, and acetyl-CoA acetyltransferase, respectively. …”
Publicado 2018
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5446por Boerboom, Gavin, van Kempen, Theo, Navarro-Villa, Alberto, Pérez-Bonilla, Adriano“…Mitochondrial fatty acid oxidation was limited due to disturbances in especially cis-5–14:1 carnitine (log2 FC of 2, P < 0.01). Because of this, accumulation of harmful fatty acids took place, especially long-chain ones, which damages cell structures. …”
Publicado 2018
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5447“…Crocin inhibited the mRNA expression of lipogenesis-associated genes, including sterol regulatory element binding protein-1c, peroxisome proliferator-activated receptor γ, fatty acid synthase, stearoyl-CoA desaturase 1, and diacylglycerol acyltransferase 1, and increased the mRNA expression of genes involved in the regulation of β-oxidation of fatty acids, including PPARα, acyl-CoA oxidase 1, carnitine palmitoyltransferase 1, and 3-hydroxy-3-methylglutaryl-CoA synthase 2. …”
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5448por Hassan, Fardos A. M., Roushdy, Elshimaa M., Kishawy, Asmaa T. Y., Zaglool, Asmaa W., Tukur, Hammed A., Saadeldin, Islam M.“…Of the lipid-related genes examined, acetyl CoA carboxylase and fatty acid synthase were significantly down-regulated in the livers of rutin-fed individuals, whereas carnitine palmitoyl transferase 1 and peroxisome proliferator-activated receptor alpha were significantly up-regulated. …”
Publicado 2018
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5449“…After treatments with hydroxycobalamin, betaine, folic acid, L-carnitine, and compound vitamin B, the clinical features and biochemical parameters of patients with late-onset cblC disease were found to be alleviated. …”
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5450por Xie, Yun-fei, Feng, Wu-wen, Liu, Mei-chen, Xie, Jun, Yu, Lei, Gong, Xiao-hong, Li, Yun-xia, Peng, Cheng“…High dose of lipid-soluble alkaloids of FZ could increase the plasma contents of L-lysine, L-arginine, and deoxycholic acid, while the plasma contents of UMP, carnitine, N-formylanthranilic acid, and adenosine were decreased significantly. …”
Publicado 2019
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5451por Santos, Tiago, Viala, Didier, Chambon, Christophe, Esbelin, Julia, Hébraud, Michel“…We observed some noteworthy protein abundance shifts associated with the major adaptation to cold mechanisms present in L. monocytogenes, namely: the role of ribosomes and the stressosome with a higher abundance of the general stress protein Ctc (Rl25) and the general stress transcription factor sigma B (σ(B)), changes in cell fluidity and motility seen by higher levels of foldase protein PrsA2 and flagellin (FlaA), the uptake of osmolytes with a higher abundance of glycine betaine (GbuB) and carnitine transporters (OpucA), and the relevance of the overexpression of chaperone proteins such as cold shock proteins (CspLA and Dps). …”
Publicado 2019
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5452por Boteon, Yuri L., Attard, Joseph, Boteon, Amanda P. C. S., Wallace, Lorraine, Reynolds, Gary, Hubscher, Stefan, Mirza, Darius F., Mergental, Hynek, Bhogal, Ricky H., Afford, Simon C.“…This effect was driven by increased solubility of the triglycerides (P = 0.04), and mitochondrial oxidation as assessed by increased ketogenesis (P = 0.008) and adenosine triphosphate synthesis (P = 0.01) were associated with increased levels of the enzymes acyl‐coenzyme A oxidase 1, carnitine palmitoyltransferase 1A, and acetyl‐coenzyme A synthetase. …”
Publicado 2019
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5453“…In addition, LSDP5 upregulated the expression levels of B-cell lymphoma-2, acetyl-CoA carboxylase1/2 and fatty acid synthase (Fas), whereas the expression levels of activated-caspase-3, Bcl-2-associated X protein, cytochrome c, cytochrome c oxidase subunits IV, carnitine palmitoyltransferase 1a and peroxisome proliferator-activated receptors α levels were downregulated. …”
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5454por Baltazar-Martins, Gabriel, Brito de Souza, Diego, Aguilar-Navarro, Millán, Muñoz-Guerra, Jesús, Plata, María del Mar, Del Coso, Juan“…Additionally, as per group of supplements according to IOC consensus, 18% of the supplements were rated as having a low level of scientific evidence (e.g., glutamine, HMB, L-carnitine, etc). Most athletes (45%, n = 152) purchased dietary supplements in a store and 24% (n = 81) obtained them from a sponsor. …”
Publicado 2019
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5455por Hong, Meiling, Li, Na, Li, Jiangyue, Li, Weihao, Liang, Lingyue, Li, Qian, Wang, Runqi, Shi, Haitao, Storey, Kenneth B., Ding, Li“…In addition, the high expression of the peroxisome proliferator activated receptor-α (PPARα) transcription factor that, in turn, facilitated upregulation of target genes including carnitine palmitoyltransferase (CPT) and acyl-CoA oxidase (ACO). …”
Publicado 2019
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5456por Zhang, Yumei, Guo, Songge, Xie, Chunyan, Wang, Ruxia, Zhang, Yan, Zhou, Xihong, Wu, Xin“…Experiments about key enzymes that are involved in de novo synthesis of fatty acid showed that the gene expression of liver X receptors (LXRα), sterol regulatory element-binding transcription factor 1 (SREBP1c), fatty acid desaturase 2 (FADS2), and fatty acid elongase 5 (ELOVL5) were remarkably down-regulated (p < 0.05) with UMP and UR treatment, and key factors of adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and carnitine palmitoyl transferase 1 (CPT-1α) involved in fatty acid catabolism were also decreased (p < 0.05). …”
Publicado 2019
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5457“…Furthermore, after sesamol treatment, the hepatic sterol regulatory element binding protein-1 (SREBP-1c) decreased, while the phosphorylated hormone sensitive lipase (p-HSL), the carnitine palmitoyltransferase 1α (CPT1α), and the peroxisome proliferator-activated receptor coactivator-1α (PGC1α) increased, which were responsible for the fatty acid synthesis, lipolysis, and fatty acid β-oxidation, respectively. …”
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5458por Liu, Lei, Shi, Xiaoqing, Yue, Peng, Zheng, Xiaolan, Hua, Yimin, Zhou, Kaiyu, Li, Yifei“…This child received digoxin, hydrochlorothiazide, spironolactone diuresis, captopril, and L-carnitine, and the symptoms of heart failure had been controlled as the patient waited for heart transplantation. …”
Publicado 2019
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5459por Wang, Guoying, Sun, Qi, Liang, Liming, Clash, Clary, Zhang, Cuilin, Hong, Xiumei, Ji, Yuelong, Radovick, Sally, Pearson, Colleen, Bartell, Tami R., Zuckerman, Barry, Cheng, Tina L., Hu, Frank B., Wang, Xiaobin“…Maternal OWO had a significant association with childhood OWO, both in term and preterm births. β-hydroxybutyryl-carnitine (C4-OH) levels were significantly and positively associated with child OWO among term births after adjustment for potential confounders and multiple-comparisons. …”
Publicado 2019
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5460por Xu, Xiaojiao, Chen, Xiaoling, Huang, Zhiqing, Chen, Daiwen, He, Jun, Zheng, Ping, Chen, Hong, Luo, Junqiu, Luo, Yuheng, Yu, Bing, Yu, Jie“…In the liver, SOD1, CAT, GPX1, GST, NF-E2-related nuclear factor 2 (Nrf2), hormone sensitive lipase (HSL), carnitine palmitoyl transferase-1b (CPT1b), peroxisome proliferator-activated receptor α (PPARα), cholesterol 7α-hydroxylase (CYP7A1) and low-density lipoprotein receptor (LDL-R) mRNA levels were increased by APPs, while Kelch-like ECH-associated protein 1 (Keap1) mRNA level, C16:0 and C20:4n-6 proportions and Δ9-18 dehydrogenase activity were decreased. …”
Publicado 2019
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