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5521“…Amino acid analysis of the blood revealed an enhancement in serum homocysteine levels and a decrease in blood methionine and free carnitine levels. The organic acid levels in urine were normal. …”
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5522por Murko, Simona, Aseman, Asra Dadkhah, Reinhardt, Friederike, Gramer, Gwendolyn, Okun, Jürgen Günther, Mütze, Ulrike, Santer, René“…Newborn screening (NBS) for isovaleric acidemia (IVA) is performed by flow injection tandem mass spectrometry quantifying C5 carnitines (C5). Isovalerylcarnitine, however, is isomeric with pivaloylcarnitine which can be present in blood due to maternal use of pivaloylester‐containing antibiotics, available in Germany since late 2016. …”
Publicado 2022
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5523por De los Santos-Jiménez, Juan, Rosales, Tracy, Ko, Bookyung, Campos-Sandoval, José A., Alonso, Francisco J., Márquez, Javier, DeBerardinis, Ralph J., Matés, José M.“…The levels of some acetylated and methylated metabolites were significantly increased, including acetyl-carnitine, trimethyl-lysine, and 5-methylcytosine. …”
Publicado 2023
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5524por Janovska, Petra, Zouhar, Petr, Bardova, Kristina, Otahal, Jakub, Vrbacky, Marek, Mracek, Tomas, Adamcova, Katerina, Lenkova, Lucie, Funda, Jiri, Cajka, Tomas, Drahota, Zdenek, Stanic, Sara, Rustan, Arild C., Horakova, Olga, Houstek, Josef, Rossmeisl, Martin, Kopecky, Jan“…On the contrary, lipidomic, proteomic and gene expression analyses along with palmitoyl carnitine oxidation and cytochrome c oxidase activity revealed induction of lipid oxidation exclusively in skeletal muscle of A/J mice subjected to CA. …”
Publicado 2023
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5525por Zhang, Ke, Liu, Gongwei, Wu, Yujiang, Zhang, Ting, Guo, Mengmeng, Lei, Yu, Cao, Xi, Suo, Langda, Brugger, Daniel, Wang, Xiaolong, Yang, Yuxin, Chen, Yulin“…Several specific gut metabolites, including carnitine C8:1, γ-aminobutyric acid, and indole-3-carboxylic acid, were negatively correlated with the fecal and serum estradiol concentrations. …”
Publicado 2023
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5526“…Results indicated that no interactions between dietary concentrations of ME and NDF were observed for all measurements except for egg yolk color, eggshell thickness, and 2 hepatic gene expressions (i.e., carnitine palmitoyl transferase 1A and malic enzyme). …”
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5527por Chen, Jun, Wang, Jianjun, Gan, Jing, Luo, Rong, Yang, Zuozhen, Liang, Mengmeng, Chen, Xiaolu“…The patient was diagnosed with anti-AQP4–IgG-positive LS, treated with “cocktail therapy” (vitamins B1, B2, C, and E, l-carnitine, and coenzyme Q10), and discharged after his condition improved. …”
Publicado 2023
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5528por Chen, Chengzhuang, Xu, Chang, Yang, Xiaolong, Jia, Yongyi, Gu, Zhimin, Li, Erchao“…There was no significant difference in acetyl-CoA carboxylase and carnitine palmitoyltransferase-1 contents in crayfish among all the groups (P > 0.05). …”
Publicado 2022
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5529“…The expression of downstream genes such as fatty acid binding protein 3 (FABP3) and carnitine palmitoyltransferase 1A (CPT1A) was increased. …”
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5530por Song, Jingyi, Duivenvoorde, Loes P. M., Grefte, Sander, Kuda, Ondrej, Martínez-Ramírez, Felipe, van der Stelt, Inge, Mastorakou, Dimitra, van Schothorst, Evert M., Keijer, Jaap“…Trib3 positively correlated with blood glucose levels. Upregulated carnitine palmitoyltransferase 1A negatively correlated with the RER, but the significantly increased in tissue C14-1, C16-0 and C18-1 acylcarnitines supported that β-oxidation was not regulated. …”
Publicado 2023
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5531“…It measured levels of immune factors tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), carnitine palmitoyltransferase-1 (CPT1), transforming growth factor-β1 (TGF-β1), glucose (Glu), lactic acid (LD), interleukin 10 (IL-10), and selenoprotein 1 (SEP1) using ELISA, as well as to confirm dysregulation of lipid metabolism in hyperuricemia. 33 differential lipid metabolites were significantly upregulated in patients with hyperuricemia. …”
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5532por Zhong, Ziwen, Zhang, Hao, Nan, Ke, Zhong, Jing, Wu, Qichao, Lu, Lihong, Yue, Ying, Zhang, Zhenyu, Guo, Miaomiao, Wang, Zhiqiang, Xia, Jie, Xing, Yun, Fu, Ying, Yu, Baichao, Zhou, Wenchang, Sun, Xingfeng, Shen, Yang, Chen, Wankun, Zhang, Jie, Zhang, Jin, Ma, Duan, Chu, Yiwei, Liu, Ronghua, Miao, Changhong“…IgA(+) B-cell expansion was also impeded in patients placed on FMD, while B-cell expression of carnitine palmitoyl transferase 1A (CPT1A), the rate-limiting enzyme of FAO, was increased. …”
Publicado 2023
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5533por Voruganti, V. Saroja, Higgins, Paul B., Ebbesson, Sven O. E., Kennish, John, Göring, Harald H. H., Haack, Karin, Laston, Sandra, Drigalenko, Eugene, Wenger, Charlotte R., Harris, William S., Fabsitz, Richard R., Devereux, Richard B., MacCluer, Jean W., Curran, Joanne E., Carless, Melanie A., Johnson, Matthew P., Moses, Eric K., Blangero, John, Umans, Jason G., Howard, Barbara V., Cole, Shelley A., Comuzzie, Anthony Gean“…The confidence interval contains candidate genes FADS1, FADS2, 7-dehydrocholesterol reductase (DHCR7), and carnitine palmitoyl transferase 1A, liver (CPT1A). …”
Publicado 2012
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5534por Touw, Catharina M L, Smit, G Peter A, de Vries, Maaike, de Klerk, Johannis B C, Bosch, Annet M, Visser, Gepke, Mulder, Margot F, Rubio-Gozalbo, M Estela, Elvers, Bert, Niezen-Koning, Klary E, Wanders, Ronald J A, Waterham, Hans R, Reijngoud, Dirk-Jan, Derks, Terry G J“…After diagnosis and initiation of treatment, residual MCAD enzyme activities <10% were associated with an increased risk of hypoglycaemia and carnitine supplementation. The prevalence of MCAD deficiency upon screening was 1/8,750 (95% CI 1/7,210–1/11,130). …”
Publicado 2012
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5535por Pons-Rejraji, Hanae, Brugnon, Florence, Sion, Benoit, Maqdasy, Salwan, Gouby, Gerald, Pereira, Bruno, Marceau, Geoffroy, Gremeau, Anne-Sophie, Drevet, Joel, Grizard, Genevieve, Janny, Laurent, Tauveron, Igor“…Seminal concentrations of acid phosphatases (p < 0.01), α-glucosidase (p < 0.05) and L-carnitine (p < 0.05) were also decreased during the therapy, indicating an alteration of prostatic and epididymal functions. …”
Publicado 2014
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5536por Baumgartner, Matthias R, Hörster, Friederike, Dionisi-Vici, Carlo, Haliloglu, Goknur, Karall, Daniela, Chapman, Kimberly A, Huemer, Martina, Hochuli, Michel, Assoun, Murielle, Ballhausen, Diana, Burlina, Alberto, Fowler, Brian, Grünert, Sarah C, Grünewald, Stephanie, Honzik, Tomas, Merinero, Begoña, Pérez-Cerdá, Celia, Scholl-Bürgi, Sabine, Skovby, Flemming, Wijburg, Frits, MacDonald, Anita, Martinelli, Diego, Sass, Jörn Oliver, Valayannopoulos, Vassili, Chakrapani, Anupam“…Except for vitamin B(12) responsive forms of MMA the outcome remains poor despite the existence of apparently effective therapy with a low protein diet and carnitine. This may be related to under recognition and delayed diagnosis due to nonspecific clinical presentation and insufficient awareness of health care professionals because of disease rarity. …”
Publicado 2014
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5537por Yoshizawa, Toshihiko, Omori, Kazuhiko, Takeuchi, Ikuto, Miyoshi, Yuto, Kido, Hiroshi, Takahashi, Etsuhisa, Jitsuiki, Kei, Ishikawa, Kouhei, Ohsaka, Hiromichi, Sugita, Manabu, Yanagawa, Youichi“…Later, a genetic analysis revealed that he had a thermolabile genetic phenotype of carnitine palmitoyltransferase II (CPT II). CONCLUSIONS: Physicians should pay special attention to the stress of rehabilitation exercises, which may cause collapsed muscles that are injured by severe heat stroke to repeatedly flare up.…”
Publicado 2016
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5538por Koh, Angela S., Gao, Fei, Leng, Shuang, Kovalik, Jean-Paul, Zhao, Xiaodan, Tan, Ru San, Fridianto, Kevin Timothy, Ching, Jianhong, Chua, Serene JM, Yuan, Jian-Min, Koh, Woon-Puay, Zhong, Liang“…Medium and long chain dicarboxyl carnitines were associated with εs (β = −0.6, p = 0.038). …”
Publicado 2018
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5539por Sarker, Suprovath Kumar, Islam, Md Tarikul, Biswas, Aparna, Bhuyan, Golam Sarower, Sultana, Rosy, Sultana, Nusrat, Rakhshanda, Shagoofa, Begum, Mst. Noorjahan, Rahat, Asifuzzaman, Yeasmin, Sharmina, Khanam, Mowshori, Saha, Asim Kumar, Noor, Farjana Akther, Sajib, Abu A., Islam, Abul B. M. M. K., Qadri, Syeda Kashfi, Shahidullah, Mohammod, Mannan, Mohammad Abdul, Muraduzzaman, A. K. M., Shirin, Tahmina, Rahman, Sheikh Maksudur, Qadri, Syed Saleheen, Saha, Narayan, Akhteruzzaman, Sharif, Qadri, Firdausi, Mannoor, Kaiissar“…Out of 9 cases that came out as screening positive by LC-MS/MS, seven cases were confirmed by urinary GC-MS analysis including 3 cases with phenylketonuria, 1 with citrullinemia type II, 1 with methylmalonic acidemia, 1 with isovaleric acidemia and 1 with carnitine uptake defect. Two borderline positive cases with MCAD were found negative by urinary GC-MS analysis. …”
Publicado 2019
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5540por Chautard, Robin, Laroche-Raynaud, Cécile, Lia, Anne-Sophie, Chazelas, Pauline, Derouault, Paco, Sturtz, Franck, Baaj, Yasser, Veauville-Merllié, Alice, Acquaviva, Cécile, Favreau, Frédéric, Faye, Pierre-Antoine“…Treatment was based on avoiding fasting and a slow carbohydrate-rich evening meal associated with L-carnitine supplementation (approximately 100 mg/kg/day) for several weeks. …”
Publicado 2020
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