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5641
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5642por Tong, Fangle, Bai, Jinhai, Tang, Zhongtian, Li, Chunyan, Liu, Shaojun, Wei, Zehong“…In addition, the expression levels of insulin-like growth factor-1 (IGF-1) of the liver in all HC groups and lipolysis-related genes (lipoprotein lipase (LPL), carnitine O-palmitoyltransferase 1 (CPT 1) and hydroxyacyl-coenzyme A dehydrogenase (HADH)) of the liver in the 6% of HC group increased significantly (p < 0.05), and the expression levels of lipogenesis-related genes (fatty acid synthase (FAS) and sterol regulatory element-binding protein 1 (SREBP 1)) of the liver in the 4% HC and 6% HC groups decreased significantly (p < 0.05). …”
Publicado 2023
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5643“…Additionally, the lipid metabolism-related genes including lipoprotein lipase (lpl), peroxisome proliferators-activated receptor (pparα), carnitine palmitoyltransferase-1 (cpt-1), and sterol regulatory element binding protein-1 (srebp-1) were markedly downregulated in the HD and/or MD group after 90 days of farming. …”
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5644por Izadpanah, Amin, Mudd, Joseph C., Garcia, Joe G. N., Srivastav, Sudesh, Abdel-Mohsen, Mohamed, Palmer, Clovis, Goldman, Aaron R., Kolls, Jay K., Qin, Xuebin, Rappaport, Jay“…We observed a significant increase in lipid metabolites, including eicosadienoic acid, oleic acid, and palmitoyl carnitine in the low dose antibody + NR group. We also observed significantly increased nicotinamide related metabolites in NR treated animals. …”
Publicado 2023
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5645“…No substantial difference was discerned in fasting total carnitine levels (SMD: 0.15, 95% CI: −0.16–0.31, I(2) = 68.2%), medium-chain acylcarnitines (MCAC) (SMD: 0.08, 95% CI: −0.02–0.36, I(2) = 79.0%), and long-chain acylcarnitines (LCAC) (SMD: 0.04, 95% CI: −0.06–0.15, I(2) = 0%). …”
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5646por Wang, Jun-Xian, Qiao, Fang, Zhang, Mei-Ling, Chen, Li-Qiao, Du, Zhen-Yu, Luo, Yuan“…Additionally, the 4% sodium citrate significantly increased hepatic triglyceride and acetyl-CoA levels, while the expressions of carnitine palmitoyl transferase 1a protein were significantly down-regulated by the 4% sodium citrate (P < 0.05). …”
Publicado 2023
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5647“…Metabolic KEGG pathway analysis revealed that 6 pathways, including fatty acid metabolism, sphingolipid metabolism, TCA cycle, transsulfuration pathway, bile acid metabolism, and carnitine metabolism were both enriched in mothers and newborns. …”
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5648por Correnti, Serena, Preianò, Mariaimmacolata, Fregola, Annalisa, Gamboni, Fabia, Stephenson, Daniel, Savino, Rocco, D’Alessandro, Angelo, Terracciano, Rosa“…In particular, we confirmed significantly decreased levels of PS and carnitines in infertile patients as well as the positive correlation with sperm motility and morphology. …”
Publicado 2023
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5649por Kang, Chunbo, Zhang, Jie, Xue, Mei, Li, Xiaowei, Ding, Danyang, Wang, Ye, Jiang, Shujing, Chu, Fong-Fong, Gao, Qiang, Zhang, Mengqiao“…The metabolites with decreased levels in the CRC tissue included quinaldic acid (also referred to as quinoline-2-carboxilic acid), 17α- and 17β-estradiol, which are associated with tumor suppression activities, as well as other metabolites such as, anhydro-β-glucose, Asp-Arg, lysophosphatidylcholine, lysophosphatidylethanolamine (lysoPE), lysophosphatidylinositol, carnitine, 5′-deoxy-5′-(methylthio) adenosine, 2′-deoxyinosine-5′-monophosphate and thiamine monophosphate. …”
Publicado 2023
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5650por Zhou, Ting, Wang, Shiyuan, Pan, Yajing, Dong, Xingtong, Wu, Leiyun, Meng, Jiali, Zhang, Jialing, Pang, Qi, Zhang, Aihua“…Blood urea nitrogen and creatinine levels, body and muscle weight, and muscle histology were assessed. The expression of carnitine palmitoyltransferase 1A (CPT1A) and pyroptosis-related protein was analysed by Western blots or immunohistochemistry. …”
Publicado 2023
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5651por Whitby, Alison, Pabla, Pardeep, Shastri, Bhoomi, Amugi, Laudina, Del Río-Álvarez, Álvaro, Kim, Dong-Hyun, Royo, Laura, Armengol, Carolina, Dandapani, Madhumita“…Gene set enrichment analysis (GSEA) from RNAseq data (n = 32 paired HB and NT samples) demonstrated a downregulation of the carnitine metabolome and immunohistochemistry showed a reduction in CPT1a (n = 15 pairs), which transports fatty acids into the mitochondria, suggesting a lack of utilisation of long-chain fatty acids in HB. …”
Publicado 2023
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5652“…In addition, to investigate the effect on hepatic TG metabolism, carnitine palmitoyltransferase (CPT) activity in mice was evaluated after consecutive ingestion (6 days) of GCBE and its constituents (caffeine, chlorogenic acid, neochlorogenic acid and feruloylquinic acid mixture). …”
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5653por Chiechio, Santina, Copani, Agata, De Petris, Laura, Morales, Maria Elena P, Nicoletti, Ferdinando, Gereau, Robert W“…Accordingly, we show that carnitine, which has no effect on pain thresholds, had no effect on p65/RelA acetylation and did not enhance mGlu2 expression. …”
Publicado 2006
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5654“…These SNPs were located within DHDH (dihydrodiol dehydrogenase dimeric), CPT1C (carnitine palmitoyltransferase 1C), TNNT1, and NALP7. …”
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5655por Zúñiga, Jessica, Cancino, Milena, Medina, Fernando, Varela, Patricia, Vargas, Romina, Tapia, Gladys, Videla, Luis A., Fernández, Virginia“…PPAR-α activation by n-3 PUFA was evidenced by enhancement in the expression of the PPAR-α-regulated Acyl-CoA oxidase (Acox) and Carnitine-Palmitoyl-CoA transferase I (CPT-I) genes. …”
Publicado 2011
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5656“…Mutation analyses included synaptotagmin 3 and 5 (SYT3, SYT5), carnitine palmitoyl-transferase 1C (CPT1C) on bovine chromosome 18 (BTA18), and plexin C1 (PLXNC1), intracellular suppressor of cytokine signaling-2 (SOCS2), and kinesin family member 21A (KIF21A) on BTA5. …”
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5657por Ellero-Simatos, Sandrine, Szymańska, Ewa, Rullmann, Ton, Dokter, Wim HA, Ramaker, Raymond, Berger, Ruud, van Iersel, Thijs MP, Smilde, Age K, Hankemeier, Thomas, Alkema, Wynand“…Prednisolone treatment also strongly increased urinary carnitine derivatives at day 1 but not at day 15, which might reflect adaptive mechanisms under prolonged treatment. …”
Publicado 2012
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5658“…The expression level of miR-33 increases significantly in the liver after 19 days in comparison with the control group; (2) By using the bioinformatics software programs TargetScan, miRDB and miRCosm to predict the target genes of miR-33 according to laboratory prophase transcriptome results and references, we screen nine target genes: adenosine triphosphate binding cassette transporters A1, adenosine triphosphate binding cassette transporters G1, Neimann Pick C, carnitine O-octanoyltransferase (CROT), cyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase, beta subunit (HADHB), AMP-activated protein kinase, alpha subunit 1 (AMPKα1), insulin receptor substrate 2, glutamic pyruvate transaminase and adipose differentiation-related protein. …”
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5659por Bochnia, M., Ziegler, J., Sander, J., Uhlig, A., Schaefer, S., Vollstedt, S., Glatter, M., Abel, S., Recknagel, S., Schusser, G. F., Wensch-Dorendorf, M., Zeyner, A.“…Healthy cograzing horses on AM-pastures showed higher serum (108.8 ± 83.76 μg/L) and urine concentrations (26.9 ± 7.39 μg/L) compared to control horses, but lower concentrations compared to diseased horses. The range of MCPA-carnitine and creatinine concentrations found in diseased horses in serum and urine were 0.17–0.65 mmol/L (controls < 0.01), and 0.34–2.05 μmol/mmoL (controls < 0.001), respectively. …”
Publicado 2015
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5660por Mehlgarten, Constance, Krijger, Jorrit-Jan, Lemnian, Ioana, Gohr, André, Kasper, Lydia, Diesing, Anne-Kathrin, Grosse, Ivo, Breunig, Karin D.“…We find that in K. lactis, but not in S. cerevisiae, the Sip4 protein plays an essential role in C2 carbon assimilation including induction of the glyoxylate cycle and the carnitine shuttle genes. Induction of KlSIP4 gene expression by KlCat8 is essential under these growth conditions and a primary function of KlCat8. …”
Publicado 2015
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