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5801“…Gene expression of fatty acid synthase (FAS) was higher (p<0.05) in the IC group than in the other groups, and choline supplementation decreased (p<0.05) FAS and acetyl-CoA carboxylase α expression in the livers of the IUGR pigs. The expression of carnitine palmitoyl transferase 1A (CPT1A) was lower (p<0.05) in the IC group than in the other groups, and choline supplementation increased (p<0.05) the expression of CPT1A in the liver of the IUGR pigs and decreased (p<0.01) the expression of hormone-sensitive lipase in both types of pigs. …”
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5802por Ge, Xie, Pan, Peng, Jing, Jun, Hu, Xuechun, Chen, Li, Qiu, Xuhua, Ma, Rujun, Jueraitetibaike, Kadiliya, Huang, Xuan, Yao, Bing“…The results demonstrated that although RSG did not affect the endocytosis of PA, it significantly elevated the expression of carnitine palmitoyltransferase (CPT)-1A, a key enzyme involved in fatty acid oxidation, which indicated that the protective effect of RSG may have an important role in fatty acid oxidation. …”
Publicado 2018
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5803“…RESULTS: Compared with HepG2 cells cultured in normal growth medium, glucose production of HepG2 cells treated by FFA was significantly increased {[(0.28 ± 0.01) vs (0.83 ± 0.02)] umol.ug(− 1) protein, n = 6 wells, P < 0.01}; the mRNA expression of phosphoenolpyruvate carboxylase kinase (PEPCK) and glucose-6-phosphatase (G6PC) in HepG2 cells increased by more than 5-fold and 3-fold, respectively; the mRNA expression of fatty acid synthase (FAS) and stearoyl-CoA desaturase-1 (SCD1) increased by approximately 4-fold and 1.1-fold, respectively; the mRNA expression of carnitine palmitoyltransferase-1 (CPT-1) changed slightly. …”
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5804“…In this study, compared to control cells, the protein level of β-oxidative Key enzyme, carnitine palmitoyl-transferase 1α in SCs exposed to palmitic acid was decreased (P<0.01), along with the increase of intracellular lipid droplets. …”
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5805por Strand, Elin, Lysne, Vegard, Grinna, Mari Lausund, Bohov, Pavol, Svardal, Asbjørn, Nygård, Ottar, Berge, Rolf K., Bjørndal, Bodil“…Treatment with the PPARα agonist was associated with higher liver mass relative to body weight (liver index), lower plasma, and hepatic total cholesterol, as well as lower plasma carnitine and acylcarnitines, compared with control. …”
Publicado 2019
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5806por Wang, Yinfang, Wan, Xiaohong, Hao, Yilong, Zhao, Yuanyuan, Du, Lanlan, Huang, Yitong, Liu, Zongjun, Wang, Ying, Wang, Nanping, Zhang, Peng“…NR6A1 knockdown also increased the expression of carnitine palmitoyltransferase 1A (CPT1a), the rate-limiting enzyme in fatty acid oxidation. …”
Publicado 2019
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5807por Atkins, Hannah M., Bharadwaj, Manish S., O’Brien Cox, Anderson, Furdui, Cristina M., Appt, Susan E., Caudell, David L.“…Targeted metabolomics performed on tissue revealed carnitine (p = 0.001), creatine phosphate (p = 0.01), NADH (p = 0.0001), FAD (p = 0.001), tryptophan (p = 0.0009), and malic acid (p = 0.005) were decreased in endometriosis tissue compared to normal endometrium samples. …”
Publicado 2019
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5808por Horikoshi, Yuichi, Yan, Yasheng, Terashvili, Maia, Wells, Clive, Horikoshi, Hisako, Fujita, Satoshi, Bosnjak, Zeljko J., Bai, Xiaowen“…Mature iPSC-CMs also displayed a larger change in basal and maximum respirations due to the utilization of exogenous fatty acids (palmitate) compared with non-matured control iPSC-CMs. Etomoxir (a carnitine palmitoyltransferase 1 inhibitor) but not 2-deoxyglucose (an inhibitor of glycolysis) abolished the palmitate pretreatment-mediated OCR increases in mature iPSC-CMs. …”
Publicado 2019
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5809por Xu, Shengyu, Zhang, Pan, Cao, Meng, Dong, Yanpeng, Li, Jian, Lin, Yan, Che, Lianqiang, Fang, Zhengfeng, Feng, Bin, Zhuo, Yong, Wang, Jianping, Ren, Zhihua, Wu, De“…Furthermore, the expression of carnitine palmityl transferase (CPT-1) and peroxisome proliferator-activated receptor-α (PPAR-α) in gilt liver in SPV treatment was increased (p < 0.05) in comparison with CON treatment. …”
Publicado 2019
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5810“…Levels of the blood biomarkers cortisol, DHEA-S, TNF-α, IL-6, prolactin, carnitine, TGF-β1, BDNF, MHPG, HVA, and α-MSH were measured. …”
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5811por Chen, Xue-Yang, Cai, Chang-Zhou, Yu, Meng-Li, Feng, Ze-Min, Zhang, Yu-Wei, Liu, Pei-Hao, Zeng, Hang, Yu, Chao-Hui“…In addition, LB100 significantly downregulated the protein levels of acetyl-CoA carboxylase, sterol regulatory element-binding protein 1 and its lipogenesis target genes, including stearoyl-CoA desaturase-1 and fatty acid synthase, and upregulated the levels of proteins involved in fatty acid β-oxidation, such as peroxisome proliferator-activated receptor α (PPARα), peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), carnitine palmitoyltransferase 1α, acyl-CoA oxidase 1 and uncoupling protein 2, as well as the upstream mediators Sirt1 and AMPKα in the livers of HFD-fed mice. …”
Publicado 2019
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5812por Meyer, Sandra, Gessner, Denise K., Braune, Maria S., Friedhoff, Theresa, Most, Erika, Höring, Marcus, Liebisch, Gerhard, Zorn, Holger, Eder, Klaus, Ringseis, Robert“…Plasma concentrations of both, major carnitine/acylcarnitine species and bile acids were not different across groups. …”
Publicado 2020
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5813por Udhaya Kumar, S., Thirumal Kumar, D., Siva, R., George Priya Doss, C., Younes, Salma, Younes, Nadin, Sidenna, Mariem, Zayed, Hatem“…The DEGs were mainly enriched in metabolic networks such as the phosphatidylinositol-3,4,5-triphosphate pathway and the carnitine pathway. Additionally, potentially enriched pathways, such as the signaling pathways induced by oxidative stress and reactive oxygen species (ROS), chemotaxis and lysophosphatidic acid signaling induced via G protein-coupled receptors (GPCRs), and the androgen receptor activation pathway, were identified from the DEGs that were mainly associated with the immune system. …”
Publicado 2020
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5814por Khan, Mehvish, Khawaja, Masuma, Haq, Mohammad Adnan Ul, Quadir, Humza, Jameson, Brian C“…Muscle fatigue progressed despite taking ubiquinol, B100 and carnitine. She was further evaluated with muscle biopsy that showed type two fiber atrophy. …”
Publicado 2020
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5815por Fernández-Hernández, Pablo, Sánchez-Calabuig, María Jesús, García-Marín, Luis Jesús, Bragado, María J., Gutiérrez-Adán, Alfonso, Millet, Óscar, Bruzzone, Chiara, González-Fernández, Lauro, Macías-García, Beatriz“…Twenty-two metabolites were identified in equine FF; among these, nine of them are not included in the composition of DMEM/F-12 or TCM-199 media, including (mean ± SEM): acetylcarnitine (0.37 ± 0.2 mM), carnitine (0.09 ± 0.01 mM), citrate (0.4 ± 0.04 mM), creatine (0.36 ± 0.14 mM), creatine phosphate (0.36 ± 0.05 mM), fumarate (0.05 ± 0.007 mM), glucose-1-phosphate (6.9 ± 0.4 mM), histamine (0.25 ± 0.01 mM), or lactate (27.3 ± 2.2 mM). …”
Publicado 2020
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5816por Andraos, Stephanie, Lange, Katherine, Clifford, Susan A, Jones, Beatrix, Thorstensen, Eric B, Kerr, Jessica A, Wake, Melissa, Saffery, Richard, Burgner, David P, O'Sullivan, Justin M“…OBJECTIVES: This study aimed to investigate parent–child concordance, age, and sex effects on plasma concentrations of TMAO and its precursors [l-carnitine, choline, betaine, and dimethylglycine (DMG)]. …”
Publicado 2020
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5817por Uengwetwanit, Tanaporn, Uawisetwathana, Umaporn, Arayamethakorn, Sopacha, Khudet, Juthatip, Chaiyapechara, Sage, Karoonuthaisiri, Nitsara, Rungrassamee, Wanilada“…The identified metabolites included those that were known to be produced by intestinal bacteria such as butyric acid, 4-indolecarbaldehyde and L-3-phenyllactic acid as well as those produced by shrimp such as acyl-carnitines and lysophosphatidylcholine. The functions of these metabolites were related to nutrient absorption and metabolisms. …”
Publicado 2020
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5818por Kemp, Paul R., Paul, Richard, Hinken, Aaron C., Neil, David, Russell, Alan, Griffiths, Mark J.“…These clusters were mainly composed of acyl carnitines and dicarboxylates indicating that pre‐existing mitochondrial dysfunction contributes to muscle loss following surgery. …”
Publicado 2020
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5819por Moore, Robin, Anturaniemi, Johanna, Velagapudi, Vidya, Nandania, Jatin, Barrouin-Melo, Stella Maria, Hielm-Björkman, Anna“…Likely due to the higher meat content of the RMBD, higher concentrations of several carnitines and creatine were found in the RMBD cohort. …”
Publicado 2020
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5820por Zhang, Yan, Li, Wei, Chen, Ting-Ting, Yang, Yong, Wu, Meng-Yao, Luo, Jie-Ying, Gong, Yun, Zou, Liang“…Moreover, 19 potential biomarkers, including N-lactoylleucine, 2-piperidinone, isobutyryl-l-carnitine, eicosapentaenoylcholine, LysoPC(14:0), LysoPC(20:5), physagulin C, LysoPC(18:3), leukotriene D5, deoxycholic acid 3-glucuronide, glycine, pregnanediol 3-O-glucuronide, LysoPC(18:2), LysoPC(17:0/0:0), N-acetyl-leukotriene E4, LysoPC(18:0), platelet-activating factor, LysoPA(24:1), and LysoPC(18:1), which were mainly related to the amino acids metabolism, lipids metabolism, and bile acid biosynthesis, were identified. …”
Publicado 2020
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