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5941por Mobley, C Brooks, Toedebusch, Ryan G, Lockwood, Christopher M, Heese, Alexander J, Zhu, Conan, Krieger, Anna E, Cruthirds, Clayton L, Hofheins, John C, Company, Joseph M, Wiedmeyer, Charles E, Kim, Dae Y, Booth, Frank W, Roberts, Michael D“…AF contained: 1) protein concentrates from bovine colostrum and avian egg yolk; 2) herbal adaptogens and antioxidants; and 3) acetyl-L-carnitine. METHODS: Nine month-old male Brown Norway rats were allowed ad libitum access to WD for 41–43 days and randomly assigned to WD + AF feeding twice daily for the last 31–33 days (n = 8), or WD and water-placebo feeding twice daily for the last 31–33 days (n = 8). …”
Publicado 2014
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5942por Chang, Hong, Wang, Qiyan, Shi, Tianjiao, Huo, Kuiyuan, Li, Chun, Zhang, Qian, Wang, Guoli, Wang, Yuanyuan, Tang, Binghua, Wang, Wei, Wang, Yong“…Expressions of apolipoprotein A-I (ApoA-I), cluster of differentiation 36 (CD36) and fatty acid binding protein (FABP) in the heart tissues of model group were down-regulated compared with those in sham group. Expressions of carnitine palmitoyl transferase I (CPT-1A) and lipoproteinlipase (LPL) were also reduced significantly. …”
Publicado 2016
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5943por Lau, Chung-Ho E., Siskos, Alexandros P., Maitre, Léa, Robinson, Oliver, Athersuch, Toby J., Want, Elizabeth J., Urquiza, Jose, Casas, Maribel, Vafeiadi, Marina, Roumeliotaki, Theano, McEachan, Rosemary R. C., Azad, Rafaq, Haug, Line S., Meltzer, Helle M., Andrusaityte, Sandra, Petraviciene, Inga, Grazuleviciene, Regina, Thomsen, Cathrine, Wright, John, Slama, Remy, Chatzi, Leda, Vrijheid, Martine, Keun, Hector C., Coen, Muireann“…Metabolic associations to BMI z-score included a novel association with urinary 4-deoxyerythreonic acid in addition to valine, serum carnitine, short-chain acylcarnitines (C3, C5), glutamate, BCAAs, lysophosphatidylcholines (lysoPC a C14:0, lysoPC a C16:1, lysoPC a C18:1, lysoPC a C18:2) and sphingolipids (SM C16:0, SM C16:1, SM C18:1). …”
Publicado 2018
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5944por Wang, Ziwen, Li, Shanshan, Wang, Ruifeng, Guo, Liansheng, Xu, Dan, Zhang, Tieyuan, Xu, Yifan, Wang, Wenlong, Wang, Min, Gan, Zhongwei, Wang, Xiaobing“…The protein and mRNA expression levels of β3-AR, peroxisome proliferator-activated receptor-alpha (PPAR-α), peroxisome proliferator-activated receptor-gamma (PPAR-γ), mitochondrial carnitine palmitoyltransferase-1 (mCPT-1), and fatty acid translocase (FAT)/CD36 were measured by western blot analysis and RT-qPCR, respectively. …”
Publicado 2020
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5945por Shi, Lei, Zheng, You, Cheng, Zhi, Ji, Ningfei, Niu, Changming, Wang, Yan, Huang, Tingrong, Li, Ruyou, Huang, Mao, Chen, Xiaolin, Shu, Lei, Wu, Mingjing, Deng, Kaili, Wei, Jing, Wang, Xueli, Cao, Yang, Yan, Jiaxin, Feng, Ganzhu“…The assessment considered adverse effects (including effects on liver and kidney function, coagulation, ECG, tumor marker, and so on), pulmonary function, St George’s Respiratory Questionnaire (SGRQ), postinfection sequelae and serum concentration of Krebs von den Lungen-6 (KL-6), malondialdehyde (MDA), H(2)S, carnitine, and N-6 long-chain polyunsaturated fatty acids (N-6 LC-PUFAs). …”
Publicado 2022
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5946por Saadat, Nadia, Norman Ciarelli, Joseph, Pallas, Brooke, Padmanabhan, Vasantha, Vyas, Arpita K“…Prenatal T excess led to an increase in cholesterol levels only in female lambs as opposed to a decrease in levels of carnitine species (CAR) CAR 16:1 and CAR 14:1 and phosphatidylcholine species (PC) PC 39:4, PC 39:5 and PC 38:5 in male lambs. …”
Publicado 2023
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5947por Levine, Lindsay, Overdahl, Kirsten, Molsberry, Samantha, Shekhar, Skand, Jarmusch, Alan, Hall, Janet E“…While few statistically significant differences were present between fasted NEA and DEA samples, numerous chemical features were significantly upregulated in DEA post-snack samples. Specifically, 11 carnitines, 7 phosphocholines, and 8 fatty acids or fatty acid intermediates exhibited a log2fold change of 0.5 or higher (>40% increase; p ≤ 0.05) in post-snack DEA samples compared to NEA samples. …”
Publicado 2023
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5948por Degrave, Valentina, Vega Joubert, Michelle Berenice, Ingaramo, Paola, Sedan, Daniela, Andrinolo, Darío, D’Alessandro, María Eugenia, Oliva, María Eugenia“…We hypothesized that noninvasive oral cannabis oil administration improves hepatic steatosis through a lower activity of lipogenic enzymes and an increase in carnitine palmitoyltransferase-1 (CPT-1) enzyme activity involved in the mitochondrial oxidation of fatty acids. …”
Publicado 2023
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5949por Uwumiro, Fidelis, Nebuwa, Chikodili, Nwevo, Chimaobi O, Okpujie, Victory, Osemwota, Osasumwen, Obi, Emeka S, Nwoagbe, Omamuyovbi, Tejere, Ejiroghene, Adjei-Mensah, Joycelyn, Ogbodo, Charles T, Ekeh, Christopher N“…No significant association was observed between uremic syndrome, hyperhomocysteinemia, hyperuricemia, hypertriglyceridemia, leptin levels, carnitine deficiency, anemia, and the odds of experiencing CV events.…”
Publicado 2023
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5950por Lee, Hyejin, Kim, Jinhee, Park, Jun Yeon, Kang, Ki Sung, Park, Joeng Hill, Hwang, Gwi Seo“…In differentiated 3T3-L1 cells, mRNA expression levels of lipid metabolism-regulating factors, such as amplifying mouse fatty acid-binding protein 2, leptin, lipoprotein lipase, fatty acid transporter protein 1, fatty acid synthase, and 3-hydroxy-3-methylglutaryl coenzyme A reductase, were increased, whereas that of the lipolytic enzyme carnitine palmitoyltransferase-1 was decreased. Our data demonstrate that SG inversely regulated the expression of these genes in differentiated adipocytes. …”
Publicado 2017
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5951por Gautam, Aarti, Muhie, Seid, Chakraborty, Nabarun, Hoke, Allison, Donohue, Duncan, Miller, Stacy Ann, Hammamieh, Rasha, Jett, Marti“…RESULTS: At early time points post-exposure, we found significant increases in polyunsaturated, long chain fatty acid metabolites with p values ranging from as low as 0.000001 (ratio = 1.94) for the metabolite eicosapentaenoate to 0.04 (ratio = 1.36) for the metabolite adrenate when compared to time-matched controls. Multiple acyl carnitines metabolites were increased at earlier time points and could be a result of fatty acid oxidation defects with p values ranging from as low as 0.00001 (ratio = 2.95) for the metabolite octanoylcarnitine to 0.04 (ratio = 1.33) for metabolite deoxycarnitine when compared to time-matched controls. …”
Publicado 2018
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5952por Wang, Ting, Ma, Jun, Zhang, Qin, Gao, Ang, Wang, Qi, Li, Hong, Xiang, Jingjing, Wang, Benjing“…The prevalence of each IEM ranged from 1/401,660 to 1/19,128, while phenylketonuria (PKU) (1/19,128) and Mild hyperphenylalaninemia (M-HPA) (1/19,128) were the most common IEMs, followed by primary carnitine uptake defect (PCUD) (1/26,777), SCADD (1/28,690), hypermethioninemia (H-MET) (1/30,893), 3-MCCD (1/33,412) and methylmalonic acidemia (MMA) (1/40,166). …”
Publicado 2019
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5953por Fan, Liyan, Sweet, David R, Prosdocimo, Domenick A, Keerthy, Komal S, Jain, Mukesh K“…Indeed, we see defects in the expression of genes involved in the carnitine shuttle and a paucity of long-chain acylcarnitines in K15-SKO skeletal muscle. …”
Publicado 2020
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5954por Lovre, Dragana, Marlatt, Kara, Beyl, Robbie A, Burant, Charles F, Ravussin, Eric, Mauvais-Jarvis, Franck“…There were no treatment differences in carnitine or ketones levels. The skeletal muscle analysis comprised a total of 652 biochemicals, but unlike in serum, no significant treatment differences were observed in the skeletal muscle lipidome. …”
Publicado 2020
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5955por Li, Fengjin, Liu, Genli, Xue, Piliang, Ren, Zhen, Dai, Peifang, Niu, Wenying, Xin, Mu“…The relative expressions of ACC1, fatty acid synthase (FAS), stearoyl-CoA desaturase 1 (SCD1), carnitine palmityl transferase-1 (CPT-1), and SREBP-1 mRNA were detected by qRT-PCR. …”
Publicado 2021
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5956por Lee, Yujin, Nemet, Ina, Wang, Zeneng, Lai, Heidi T. M., de Oliveira Otto, Marcia C., Lemaitre, Rozenn N., Fretts, Amanda M., Sotoodehnia, Nona, Budoff, Matthew, DiDonato, Joseph A., McKnight, Barbara, Tang, W. H. Wilson, Psaty, Bruce M., Siscovick, David S., Hazen, Stanley L., Mozaffarian, Dariush“…BACKGROUND: Trimethylamine N‐oxide (TMAO) is a gut microbiota‐dependent metabolite of dietary choline, L‐carnitine, and phosphatidylcholine‐rich foods. On the basis of experimental studies and patients with prevalent disease, elevated plasma TMAO may increase risk of atherosclerotic cardiovascular disease (ASCVD). …”
Publicado 2021
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5957por Wu, Shengnan, Shen, Linghua, Chen, Qiong, Gong, Chunxiu, Yang, Yanling, Wei, Haiyan, Cao, Bingyan, Chen, Yongxing“…During the metabolic acidosis episode, we observed high dicarboxylic acid values in urine, and the elevated ratio of blood acetylcarnitine to free carnitine may have been an additional biochemical signature. …”
Publicado 2022
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5958por Engel, Connor, Meade, Rodrigo, Harroun, Nikolai, Penrose, Amanda, Shafqat, Mehreen, Jin, Xiaohua, DeSilva, Gayan, Semenkovich, Clay, Zayed, Mohamed“…Min and Max-diseased segments were obtained in real-time from CEA plaque and amputated lower extremity arterial segments. mRNA and protein were isolated from specimens and the relative expression of ppara, and its downstream genes Acyl-CoA Oxidase 1 (acox1) and Carnitine Palmitoyltransferase 1A (cpt1a) were also evaluated. …”
Publicado 2022
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5959por Ma, Yingxuan, Lu, Li, Tan, Kezhe, Li, Zhi, Guo, Ting, Wu, Yibo, Wu, Wei, Zheng, Lulu, Fan, Feilong, Mo, Jiayu, Gong, Zhenhua“…We previously reported that children with BA had abnormal lipid metabolism, including free serum carnitine. OBJECTIVE: To study gene and protein expression levels of the hepatic peroxisome proliferator-activated receptor-α (PPARα) signaling pathway and farnesoid X receptor (FXR) in BA and BA fibrosis, and assess their clinical values. …”
Publicado 2022
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5960“…Among them, some were correlated with clinical features, such as plasma hypogeic acid (r = −0.416, P = 0.005) and urine malonyl carnitine (r = −0.374, P = 0.042), which were negatively correlated with the prevalence of interstitial lung disease. …”
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