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941por Murakami, Takaaki, Nakamura, Toshihiro, Fujimoto, Hiroyuki, Fujikura, Junji, Shimizu, Yoichi, Miyake, Kanae K., Otani, Daisuke, Sakaki, Kentaro, Kiyobayashi, Sakura, Anazawa, Takayuki, Nakamoto, Yuji, Inagaki, Nobuya“…A patient with type 1 diabetes underwent noninvasive imaging following simultaneous kidney–pancreas transplantation with positron emission tomography/computed tomography (PET/CT) using an exendin‐based probe, [(18)F]FB(ePEG12)12‐exendin‐4. …”
Publicado 2023
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942por Shah, Meera, Law, Jennie H., Micheletto, Francesco, Sathananthan, Matheni, Dalla Man, Chiara, Cobelli, Claudio, Rizza, Robert A., Camilleri, Michael, Zinsmeister, Alan R., Vella, Adrian“…Subjects were studied in the presence or absence of exendin-9,39 infused at 300 pmol/kg/min. Exendin-9,39 resulted in an increase in integrated postprandial glucose concentrations post-RYGB (3.6 ± 0.5 vs. 2.0 ± 0.4 mol/6 h, P = 0.001). …”
Publicado 2014
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943por He, Shijun, Wu, Wenyu, Wan, Yihong, Nandakumar, Kutty Selva, Cai, Xiuchao, Tang, Xiaodong, Liu, Shuwen, Yao, Xingang“…Glucagon-like peptide 1 receptor (GLP-1R) agonist (Exendin-4) is a well-known agent used to improve β-cell dysfunctions via protein kinase A (PKA), but the detailed downstream molecular mechanisms are still elusive. …”
Publicado 2019
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944por Hernandez, Nicole S., Ige, Kelsey Y., Mietlicki-Baase, Elizabeth G., Molina-Castro, Gian Carlo, Turner, Christopher A., Hayes, Matthew R., Schmidt, Heath D.“…The effects of systemic exendin-4 on cocaine reinstatement were attenuated in rats pretreated with intra-VTA infusions of the GLP-1 receptor antagonist exendin-(9–39), indicating that the suppressive effects of systemic exendin-4 on cocaine seeking were due, in part, to activation of GLP-1 receptors in the VTA. …”
Publicado 2018
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945por Vegt, Erik, Eek, Annemarie, Oyen, Wim J. G., de Jong, Marion, Gotthardt, Martin, Boerman, Otto C.“…In rats, 5 mg of peptide #6 very efficiently inhibited the renal uptake of (111)In-minigastrin, by 88%. Uptake of (111)In-exendin and (111)In-octreotide was reduced by 26 and 33%, respectively. …”
Publicado 2009
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946por Kosowska, Agnieszka, Gallego-Colon, Enrique, Garczorz, Wojciech, Kłych-Ratuszny, Agnieszka, Aghdam, Mohammad Reza F, Woz´niak, Michał, Witek, Andrzej, Wróblewska-Czech, Agnieszka, Cygal, Anna, Wojnar, Jerzy, Francuz, Tomasz“…Exendin-4 inhibited migration and promoted apoptosis through caspase 3/7 activation. …”
Publicado 2017
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947“…Radiolabelling of DTPA-exendin-3, DOTA-exendin-3 and DTPA-anti-CAIX antibody in MES and HEPES buffer resulted in twofold higher specific activities than that in NaAc and NH(4)Ac. …”
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948“…Glucagon-like peptide 1 (GLP-1) is a small peptide component of the prohormone, proglucagon, that is produced in the gut. Exendin-4, a GLP-1 receptor agonist originally isolated from the saliva of H. suspectum or Gila monster, is a peptide that shares sequence and functional homology with GLP-1. …”
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949por Taher, Jennifer, Baker, Christopher L., Cuizon, Carmelle, Masoudpour, Hassan, Zhang, Rianna, Farr, Sarah, Naples, Mark, Bourdon, Celine, Pausova, Zdenka, Adeli, Khosrow“…RESULTS: Short term (7–10 day) peripheral exendin-4 enhanced satiety and also prevented fructose-induced fasting dyslipidemia and hyperinsulinemia. …”
Publicado 2014
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950por Underwood, Christina Rye, Garibay, Patrick, Knudsen, Lotte Bjerre, Hastrup, Sven, Peters, Günther H., Rudolph, Rainer, Reedtz-Runge, Steffen“…The GLP-1 receptor belongs to class B of the G-protein-coupled receptors, a subfamily characterized by a large N-terminal extracellular ligand binding domain. Exendin-4 and GLP-1 are 50% identical, and exendin-4 is a full agonist with similar affinity and potency for the GLP-1 receptor. …”
Publicado 2010
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951por Wu, Lujin, Wang, Ke, Wang, Wei, Wen, Zheng, Wang, Peihua, Liu, Lei, Wang, Dao Wen“…Here, we investigated the effects and mechanisms of the GLP‐1 analog exendin‐4 and the dipeptidyl peptidase‐4 inhibitor saxagliptin on cardiac lipid metabolism in diabetic mice (DM). …”
Publicado 2018
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952por Wartchow, Krista Minéia, Rodrigues, Letícia, Suardi, Lucas Zingano, Federhen, Barbara Carolina, Selistre, Nicholas Guerini, Gonçalves, Carlos-Alberto, Sesterheim, Patrícia“…All protocols induced the differentiation, but media supplemented with exendin-4/activin A or resveratrol induced the expression and secretion of insulin more efficiently, and only the exendin-4/activin-A-supplemented medium generated an insulin secretion profile more like β-cells, in response to glucose. …”
Publicado 2019
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953por Al-Dwairi, Ahmed, Alqudah, Tamara E, Al-Shboul, Othman, Alqudah, Mohammad, Mustafa, Ayman G, Alfaqih, Mahmoud A“…MATERIALS AND METHODS: Freshly isolated CSMCs from male BALB/c mice were cultured in DMEM and treated with vehicle, LPS (1 μg/mL), LPS+exendin-4 (50 nM), or LPS+exendin-4 (100 nM) for 24 h. …”
Publicado 2018
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954por Artinian, Shushan B., Al Lafi, Sawsan M., Boutary, Suzan S., Bitar, Khalil M., Zwainy, Nadine S., Bikhazi, Anwar B.“…The groups assessed are normal (N), streptozotocin-induced diabetic (D), Insulin treated (DI), Exendin-4 treated (DE), Aliskiren treated (DA), cotreated with Insulin and Aliskiren (DIA) and cotreated with exendin-4 and Aliskiren (DEA). …”
Publicado 2011
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955por Sharma, Shvetank, Mells, Jamie E., Fu, Ping P., Saxena, Neeraj K., Anania, Frank A.“…Steatosis, induced with all three fatty acids, was significantly resolved after exendin-4 treatment. Exendin-4 sustained levels of GRP78 expression in fat-loaded cells when compared to untreated fat-loaded cells alone. …”
Publicado 2011
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956“…In further experiments a GLP-1 receptor antagonist, exendin (9-39), and WIN 55,212-2 or a GLP-1 receptor agonist, exendin-4, and WIN 55,212-2 were injected intraperitoneally at subthreshold doses (that alone did not change food intake and body weight) to investigate whether these agents may interact to affect food intake in rats. …”
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957por Wang, Linxi, Chen, Zhou, Liu, Xiaoying, Wang, Lijing, Zhou, Yu, Huang, Jingze, Liu, Zhiqing, Lin, Donghai, Liu, Libin“…In vitro results showed that exendin-4 restored the mitochondrial functions of mesangial cells, which were perturbed by HFHG. …”
Publicado 2023
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958por Farkas, Imre, Vastagh, Csaba, Farkas, Erzsébet, Bálint, Flóra, Skrapits, Katalin, Hrabovszky, Erik, Fekete, Csaba, Liposits, Zsolt“…Whole-cell patch-clamp measurements demonstrated increased excitatory GABAergic miniature postsynaptic currents (mPSCs) frequency after Exendin-4 administration, which was eliminated by the GLP-1R antagonist Exendin-3(9–39) (1 μM). …”
Publicado 2016
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959“…From the viewpoint of evolutionary endocrinology of GLP-1 and their receptors, the incretin action of GLP-1 seems to be relatively recent. Exendin-3 and exendin-4 are paralogs of GLP-1 from the lizards, and the synthetic exendin-4, exenatide, is a paralog of GLP-1. …”
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960por Luo, Shenghe, Zuo, Yunhui, Cui, Xiaotian, Zhang, Meiping, Jin, Honghua, Hong, Lan“…Exendin9–39 demonstrated slightly decreased atrial pulse pressure; however, combined liraglutide and Exendin9–39 significantly decreased atrial pulse pressure. …”
Publicado 2023
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