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961por Manell, Elin, Puuvuori, Emmi, Svensson, Anna, Velikyan, Irina, Hulsart-Billström, Gry, Hedenqvist, Patricia, Holst, Jens Juul, Jensen Waern, Marianne, Eriksson, Olof“…Low uptake of (177)Lu-exendin-4 was found in stomach, jejunum, ileum and colon. …”
Publicado 2021
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962por Kiyobayashi, Sakura, Murakami, Takaaki, Harada, Norio, Fujimoto, Hiroyuki, Murata, Yuki, Fujita, Naotaka, Hamamatsu, Keita, Ikeguchi-Ogura, Eri, Hatoko, Tomonobu, Lu, Xuejing, Yamane, Shunsuke, Inagaki, Nobuya“…In this study, we investigated indium 111 ((111)In)-labeled exendin-4 derivative ([Lys(12)((111)In-BnDTPA-Ahx)]exendin-4) single-photon emission computed tomography/computed tomography (SPECT/CT) as a tool for evaluation of longitudinal BCM changes in HFD-induced obese mice, at the same time we also investigated the effects of GIP on BCM in response to HFD using GIP-knockout (GIP(-/-)) mice. (111)In-exendin-4 SPECT/CT was able to distinguish control-fat diet (CFD)-fed mice from HFD-fed mice and the pancreatic uptake values replicated the BCM measured by conventional histological methods. …”
Publicado 2022
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963por Baden, Megu Yamaguchi, Fukui, Kenji, Hosokawa, Yoshiya, Iwahashi, Hiromi, Imagawa, Akihisa, Shimomura, Iichiro“…Glucagon-like peptide-1 receptor, protein kinase A, and phosphatidylinositol-3 kinase inhibitors counteracted the anti-apoptotic effect of Exendin-4. CONCLUSIONS: Polyinosinic:polycytidylic acid transfection can mimic viral infection, and Exendin-4 exerted an anti-apoptotic effect both in MIN6 and insulin-producing cells from human induced pluripotent stem cells.…”
Publicado 2015
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964por Ahrén, Bo“…It was found that the insulinogenic index was reduced by 67 ± 4% by mGIP(3-30) (p < 0.001), by 60 ± 14% by exendin(9-39) (p = 0.007) and by 61 ± 14% by the combination of mGIP(3-30) and exendin(9-39) (p = 0.043), both at their highest doses, compared to animals injected with glucose in the same experimental series. …”
Publicado 2023
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965por Chang, Lina, Bi, Xinyu, Li, Shuo, Tong, Qi, Gu, Yian, He, Zonghao, Li, Yansheng, Chen, Qiusong, Cui, Jingqiu, Yu, Haonan, He, Qing, Liu, Ming“…In G1 tumors, the sensitivity of Exendin-4 PET/CT was significantly higher than that of (18)F-FDG PET/CT, but not that of (68)Ga-DOTATATE PET/CT, while in G2 tumors, the sensitivity of Exendin-4 PET/CT was significantly higher than that of both other types. …”
Publicado 2023
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966por Hedin, Karl Alex, Zhang, Hongbin, Kruse, Vibeke, Rees, Vanessa Emily, Bäckhed, Fredrik, Greiner, Thomas U., Vazquez-Uribe, Ruben, Sommer, Morten Otto Alexander“…Glucagon-like peptide-1 receptor agonists, such as Exendin-4, have emerged as potential treatments for type 2 diabetes and obesity. …”
Publicado 2023
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967por Jiménez, Amanda, Casamitjana, Roser, Viaplana-Masclans, Judith, Lacy, Antonio, Vidal, Josep“…RESULTS: Infusion of exendin-(9–39) resulted in marginal deterioration of the 2-h plasma glucose after meal intake in RYGBP subjects [saline 78.4 ± 15.1 mg/dL compared with exendin-(9–39) 116.5 ± 22.3 mg/dL; P < 0.001]. …”
Publicado 2013
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968por West, Graham M., Willard, Francis S., Sloop, Kyle W., Showalter, Aaron D., Pascal, Bruce D., Griffin, Patrick R.“…Furthermore, HDX can detect stabilization of exendin-4 and exendin-4([9-39]) hydrogen bonding networks at the N-terminal helix [Val19 to Lys27] upon binding to the N-terminal extracellular domain of GLP-1R (nGLP-1R). …”
Publicado 2014
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969por Chang, Jui-Ting, Liang, Yao-Jen, Hsu, Chia-Yu, Chen, Chao-Yi, Chen, Po-Jung, Yang, Yi-Feng, Chen, Yen-Lin, Pei, Dee, Chang, Jin-Biou, Leu, Jyh-Gang“…Similar anti-inflammatory potency was seen between 0.3 nM exendin-4 and 1 μM L-165,041. Synergic effect of exendin-4 and L-165,041 was shown in inhibiting cytokines production, but not in inhibiting RAGE expression or cell death. …”
Publicado 2017
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970“…One of these probes, (111)indium-labeled exendin-4 derivative ([Lys(12)((111)In-BnDTPA-Ahx)]exendin-4), has captured the longitudinal changes in BCM during the development and progression of diabetes and under antidiabetic therapies in various mouse models of type 1 and type 2 diabetes mellitus. …”
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971“…Graft survival increased under administration of exendin-4, with motor function improving significantly following treatment with both exendin-4 and liraglutide. …”
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972por Herz, Hussein, Song, Yang, Ye, Yuanchao, Tian, Liping, Linden, Benjamin, Abu El Haija, Marwa, Chu, Yi, Grobe, Justin L., Lengeling, Randall W., Mokadem, Mohamad“…We treated them with Exendin-9 and Exendin-4 and ran a euglycemic-hyperinsulinemic clamp. …”
Publicado 2021
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973por Chen, Haojun, Wang, Guohao, Lang, Lixin, Jacobson, Orit, Kiesewetter, Dale O., Liu, Yi, Ma, Ying, Zhang, Xianzhong, Wu, Hua, Zhu, Lei, Niu, Gang, Chen, Xiaoyuan“…Using the anti-diabetic peptide drug Exendin-4 as a model peptide, we synthesized a new long-acting Exendin-4 derivative (denoted as Abextide). …”
Publicado 2016
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974por Kooijman, Sander, Wang, Yanan, Parlevliet, Edwin T., Boon, Mariëtte R., Edelschaap, David, Snaterse, Gido, Pijl, Hanno, Romijn, Johannes A., Rensen, Patrick C. N.“…Interestingly, in DIO mice, the effects on WAT were blunted, while exendin-4 still increased sympathetic outflow towards BAT and increased the uptake of plasma TG-derived fatty acids and glucose by BAT. …”
Publicado 2015
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975por Hytting-Andreasen, Rasmus, Balk-Møller, Emilie, Hartmann, Bolette, Pedersen, Jens, Windeløv, Johanne Agerlin, Holst, Jens Juul, Kissow, Hannelouise“…Mice were injected with 5-fluorouracil or saline and received vehicle, exendin-4, teduglutide (gly2-GLP-2), or exendin-4/teduglutide in combination. …”
Publicado 2018
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976por Chen, Hui, Chan, Yik Lung, Linnane, Claire, Mao, Yilin, Anwer, Ayad G., Sapkota, Arjun, Annissa, Tiara F., Herok, George, Vissel, Bryce, Oliver, Brian G., Saad, Sonia, Gorrie, Catherine A.“…Therefore, this study aimed to investigate two drugs known to have antioxidant effects, L-carnitine and exendin-4, in rats with moderate contusive TBI. L-carnitine (1.5 mM in drinking water) or exendin-4 (15 µg/kg/day, ip) were given immediately after the injury for 2 weeks. …”
Publicado 2018
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977por Hepprich, Matthias, Antwi, Kwadwo, Waser, Beatrice, Reubi, Jean Claude, Wild, Damian, Christ, Emanuel R.“…The diagnostic role of (68)Ga-DOTA-Exendin-4 PET/CT in postbariatric hypoglycaemia for further treatment decisions is unclear. …”
Publicado 2020
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979“…Both GLP-1 and exendin-4 increased mitochondrial mass by approximately 20%. …”
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980por Kamei, Noriyasu, Suwabe, Susumu, Arime, Kenji, Bando, Hidemi, Murata, Kaho, Yamaguchi, Maika, Yokoyama, Natsuki, Tanaka, Erina, Hashimoto, Ayaka, Kanazawa, Takanori, Ago, Yukio, Takeda-Morishita, Mariko“…First, we compared the concentrations of Exendin-4 in plasma and brain after intranasal and subcutaneous administration and suggested that coadministration with L-penetratin facilitated the direct nose-to-brain transport of Exendin-4. …”
Publicado 2021
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