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981por Danila, Angela, Costea, Mariana, Profire, Lenuta, Rimbu, Cristina Mihaela, Baican, Mihaela, Lupascu, Florentina, Tatarusanu, Simona-Maria, Profire, Bianca-Stefania, Muresan, Emil-Ioan“…This study presents the production, characterization, and application of celandine (Chelidonium majus L.) extracts (aqueous, acidic, alcoholic, and ultrasound) on wool fibers and their characterization. …”
Publicado 2022
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982por Perry, Rachele A., Craig, Sarah. L., Gault, Victor A., Flatt, Peter R., Irwin, Nigel“…Subchronic antidiabetic efficacy of Ac-NT/XN-8-Gln alone, and in combination with the clinically approved GLP-1 receptor agonist exendin-4, was assessed in high-fat fed (HFF) mice. …”
Publicado 2021
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983por Boss, Marti, Bos, Desiree, Frielink, Cathelijne, Sandker, Gerwin, Bronkhorst, Patricia, van Lith, Sanne A.M., Brom, Maarten, Buitinga, Mijke, Gotthardt, Martin“…The efficacy and specificity of rtPDT with exendin-4-IRDye700DX were examined in vitro in cells with different levels of GLP-1R expression. …”
Publicado 2020
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984“…The saliva of the Gila monster contains exendin-4, a structural analogue of human GLP-1, but with a much longer half-life. …”
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985“…Moreover, administration of GLP-1 agonist exendin-4 stimulated β-cell proliferation in young but not in old mice. …”
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986por Yue, Xuyi, Yan, Xuefeng, Wu, Chenxi, Niu, Gang, Ma, Ying, Jacobson, Orit, Shen, Baozhong, Kiesewetter, Dale O., Chen, Xiaoyuan“…The in vitro cell uptake, in vivo biodistribution, and positron emission tomography (PET) imaging properties of its conjugation product with [Cys(40)]-exendin-4 were described. [(18)F]FNEM-Cys(40)-exendin-4 showed specific targeting of glucagon-like peptide 1 receptor (GLP-1R) positive insulinomas and comparable imaging results to our recently reported [(18)F]FPenM-Cys(40)-exendin-4.…”
Publicado 2014
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987“…This effect was compensated by treatment with the conditioned media from macrophages treated with the combination of LPS and exendin-4. It was also observed that exendin-4 directly inhibited the activation of NF-κB in macrophages. …”
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988“…AIM: Elevated kidney uptake in insulinoma patients remains a major limitation of radiometallated exendin-derived ligands of the glucagon-like peptide 1 receptor (GLP-1R). …”
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989por Shigeoka, Toru, Nomiyama, Takashi, Kawanami, Takako, Hamaguchi, Yuriko, Horikawa, Tsuyoshi, Tanaka, Tomoko, Irie, Shinichiro, Motonaga, Ryoko, Hamanoue, Nobuya, Tanabe, Makito, Nabeshima, Kazuki, Tanaka, Masatoshi, Yanase, Toshihiko, Kawanami, Daiji“…We have previously reported an anti‐prostate cancer effect of glucagon‐like peptide‐1 receptor (GLP‐1R) agonist exendin‐4. The attenuation of cell proliferation in the prostate cancer cell line was dependent on GLP‐1R expression. …”
Publicado 2020
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990por Zhao, Shiru, Kanoski, Scott E., Yan, Jianqun, Grill, Harvey J., Hayes, Matthew R.“…In addition, the maximum intake suppressive response that could be achieved by 4(th) icv leptin alone in non-obese rats (~33%) was shown to be further suppressed when exendin-4 was co-administered. Importantly, it was determined that the interaction between hindbrain LepR signaling and GLP-1R signaling is relevant to endogenous food intake control, as hindbrain GLP-1R blockade by the selective antagonist exendin-(9–39) attenuated the intake inhibitory effects of hindbrain leptin delivery. …”
Publicado 2012
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991“…METHODS: PPAG or exendin-4 were administered in mice treated with streptozotocin (STZ) to acutely induce beta cell death. …”
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992por Montaner, Mireia, Denom, Jessica, Jiang, Wanqing, Magnan, Christophe, Trapp, Stefan, Gurden, Hirac“…Finally, local injection of Exendin (9-39) in the OB extinguished olfactory foraging in lean mice whereas the injection of the GLP-1R agonist Exendin-4 rescued the loss of foraging behavior in obese mice. …”
Publicado 2023
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993“…RESEARCH DESIGN AND METHODS: We analyzed the capacity of β-cell expansion in 1.5- and 8-month-old mice in response to a high-fat diet, after short-term treatment with the glucagon-like peptide 1 (GLP-1) analog exendin-4, or after streptozotocin (STZ) administration. …”
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994por Vegt, Erik, Melis, Marleen, Eek, Annemarie, de Visser, Monique, Brom, Maarten, Oyen, Wim J. G., Gotthardt, Martin, de Jong, Marion, Boerman, Otto C.“…RESULTS: Megalin-deficient mice showed significantly lower uptake of all studied radiolabelled peptides in the kidneys, ranging from 22% ((111)In-octreotide) to 65% ((111)In-exendin) of uptake in wild-type kidneys. Quantitative analysis of renal uptake by SPECT and ex vivo measurements showed a very good correlation. …”
Publicado 2010
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995por Berclaz, Corinne, Pache, Christophe, Bouwens, Arno, Szlag, Daniel, Lopez, Antonio, Joosten, Lieke, Ekim, Selen, Brom, Maarten, Gotthardt, Martin, Grapin-Botton, Anne, Lasser, Theo“…Cultured cells transfected with GLP1R and incubated with Cy5.5-exendin-3 show full tracer internalization. We determined that a dose of 1 μg of Cy5.5-exendin-3 is sufficient to optically detect in vivo the tracer in islets with a high specificity. …”
Publicado 2015
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996por Hou, Shaocong, Li, Caina, Huan, Yi, Liu, Shuainan, Liu, Quan, Sun, Sujuan, Jiang, Qian, Jia, Chunming, Shen, Zhufang“…Glucagon like peptide-1 (GLP-1) receptor agonists such as exendin-4 have been widely used but their short half-life limits their therapeutic value. …”
Publicado 2015
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997por Mansouri, Shiva, Lietzau, Grazyna, Lundberg, Mathias, Nathanson, David, Nyström, Thomas, Patrone, Cesare“…Furthermore, we determine the potential role of PACAP and Exendin-4 in counteracting the effect of hypoglycaemia. …”
Publicado 2016
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998por Tsend-Ayush, Enkhjargal, He, Chuan, Myers, Mark A., Andrikopoulos, Sof, Wong, Nicole, Sexton, Patrick M., Wootten, Denise, Forbes, Briony E., Grutzner, Frank“…The importance of Glucagon like peptide 1 (GLP-1) for metabolic control and insulin release sparked the evolution of genes mimicking GLP-1 action in venomous species (e.g. Exendin-4 in Heloderma suspectum (gila monster)). …”
Publicado 2016
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999por Ferdaoussi, Mourad, Smith, Nancy, Lin, Haopeng, Bautista, Austin, Spigelman, Aliya F., Lyon, James, Dai, XiaoQing, Manning Fox, Jocelyn E., MacDonald, Patrick E.“…No clear correlation was observed between several donor or organ processing parameters and the ability of Exendin 4 to enhance insulin secretion. The ability of glucose to facilitate β‐cell exocytosis was, however, significantly correlated with responses to Exendin 4. …”
Publicado 2020
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1000por Fang, Zijian, Chen, Shiqian, Manchanda, Yusman, Bitsi, Stavroula, Pickford, Philip, David, Alessia, Shchepinova, Maria M., Corrêa Jr, Ivan R., Hodson, David J., Broichhagen, Johannes, Tate, Edward W., Reimann, Frank, Salem, Victoria, Rutter, Guy A., Tan, Tricia, Bloom, Stephen R., Tomas, Alejandra, Jones, Ben“…Our data reveal how treatment with GLP-1 versus exendin-4 is associated with preferential GLP-1R targeting towards a recycling pathway. …”
Publicado 2020
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