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Mostrando 1,021 - 1,040 Resultados de 1,737 Para Buscar 'Celendín~', tiempo de consulta: 4.77s Limitar resultados
  1. 1021
    “…Glucose-related stimulation of ISR contributed only 20% to overall ISR. Infusion with exendin(9-39) significantly reduced first- and second-phase ISR in both HS and T2DM subjects. …”
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    The Role of Endogenous Incretin Secretion as Amplifier of Glucose-Stimulated Insulin Secretion in Healthy Subjects and Patients With Type 2 Diabetes
  2. 1022
    por Fujitani, Yoshio
    Publicado 2018
    “…The authors found that the mitogenic effects of exendin‐4 require calcineurin/nuclear factor of activated T‐cells signaling, and that only in juvenile islets, exendin‐4 induced the expression of nuclear factor of activated T‐cells signaling components, as well as downstream target genes that facilitate β‐cell proliferation. …”
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    How does glucagon‐like peptide 1 stimulate human β‐cell proliferation? A lesson from islet graft experiments
  3. 1023
    “…The distinction between insulinoma and nesidioblastosis is essential since the therapeutic strategies are different. (68)Ga-DOTA-exendin-4 PET/CT emerges as a new noninvasive diagnostic tool for the localization of an endogenous source of hyperinsulinemic hypoglycemia. …”
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    Adult-onset nesidioblastosis: a challenging diagnosis revealed by glucagon-like-peptide-1 receptor imaging
  4. 1024
    “…The GLP1R antagonist exendin (9-39) and vehicle were infused in a randomized crossover design at 2 and 14 weeks. …”
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    LBSUN306 Effects Of Glp-1 Receptor Agonism, Dpp4 Inhibition, And Hypocaloric Diet On Metabolic Parameters In Obese Pre-diabetic Individuals: A Randomized-controlled Trial
  5. 1025
    “…Intraperitoneal glucose tolerance test showed that plasma glucose levels were decreased and insulin levels were increased in SKIP(−/−) mice compared to SKIP(+/+) mice, but exendin-4-enhanced insulin secretion was masked. GSIS was amplified more in SKIP(−/−) but exendin-4-enhanced insulin secretion was masked compared to that in SKIP(+/+) islets. …”
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    Sphingosine kinase 1-interacting protein is a novel regulator of glucose-stimulated insulin secretion
  6. 1026
    “…Here, we purified the family B GPCR human glucagon-like peptide-1 (GLP-1) receptor (GLP1R), whose agonists, e.g. exendin-4, are used for the treatment of type 2 diabetes mellitus. …”
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    Purification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptor
  7. 1027
    “…CONCLUSION: Ectopic insulinoma is difficult to locate before surgery. (68)Ga-Exendin-4 PET/CT has a high diagnostic value. Surgical removal of the lesion is main treatment.…”
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    Ectopic insulinoma: case report
  8. 1028
    “…Study 2 results: liraglutide response (stabilised response and total response) was not influenced by pretreatment with exendin-(9,39) (70 nmol/l) (N = 15, one dataset excluded) (p ≥ 0.609). …”
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    Locally delivered GLP-1 analogues liraglutide and exenatide enhance microvascular perfusion in individuals with and without type 2 diabetes
  9. 1029
    “…In anaesthetised rats, Exendin-4 induced lasting increases in brain tissue PO(2), indicative of increased cerebral blood flow. …”
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    Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre)conditioning neuroprotection against ischaemic stroke
  10. 1030
    “…After an i.v. injection with [(68)Ga]Ga-NODAGA-exendin-4, PET images were acquired for the quantification of pancreatic uptake of radiolabelled exendin. …”
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    Importance of beta cell mass for glycaemic control in people with type 1 diabetes
  11. 1031
    por Kruszakin, Roksana, Migdal, Paweł
    Publicado 2022
    “…The toxicity of infusions from three different plant species considered to be medicinal plants was evaluated: tansy (Tanacetum vulgare L.), greater celandine (Chelidonium majus L.), and coriander (Coriandrum sativum L.). …”
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    Toxicity Evaluation of Selected Plant Water Extracts on a Honey Bee (Apis mellifera L.) Larvae Model
  12. 1032
    “…Here, we have assessed in vivo glycemic responses to the pharmacological GLP-1R agonist exendin-4 in adult β cell–specific β-arrestin 2 knockout (KO) mice. …”
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    Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell–specific β-arrestin 2 knockout mice
  13. 1033
    “…METHODS: We therefore studied individuals with and without type 2 diabetes on two occasions in random order. On one occasion, exendin 9-39, a competitive antagonist of the GLP-1 Receptor (GLP1R), was infused, while on the other, saline was infused. …”
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    Glucagon-like peptide-1 receptor blockade impairs islet secretion and glucose metabolism in humans
  14. 1034
    “…RESULTS: In normal wild-type (WT) mouse brain, the GLP-1 receptor (GLP-1R) agonist exendin-4 selectively promotes translocation of PKC-δ (but not -βII, -α, or -ε) to the plasma membrane. …”
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    Brain GLP-1 Signaling Regulates Femoral Artery Blood Flow and Insulin Sensitivity Through Hypothalamic PKC-δ
  15. 1035
    “…RESULTS: CNTO3649 and exendin-4 reduced fasting plasma glucose (up to −30% and −28% respectively) and insulin (−43% and −65% respectively). …”
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    GLP-1 Receptor Activation Inhibits VLDL Production and Reverses Hepatic Steatosis by Decreasing Hepatic Lipogenesis in High-Fat-Fed APOE*3-Leiden Mice
  16. 1036
    “…Intravenous exenatide increased fasting EF, and exendin-9 abolished this effect. Exenatide elicited eNOS activation and NO production in endothelial cells, and induced dose-dependent vasorelaxation and reduced high-glucose or lipid-induced endothelial dysfunction in arterioles ex vivo. …”
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    Exenatide Protects Against Glucose- and Lipid-Induced Endothelial Dysfunction: Evidence for Direct Vasodilation Effect of GLP-1 Receptor Agonists in Humans
  17. 1037
    “…We also showed that this effect was significantly inhibited by exendin 9-39 (a GLP-1 antagonist) and blocked by H89. …”
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    Exenatide (a GLP-1 agonist) improves the antioxidative potential of in vitro cultured human monocytes/macrophages
  18. 1038
    “…We identified P5 in a high-throughput autocrine-based screening of large combinatorial peptide libraries, and show that P5 promotes G-protein signalling comparable to GLP-1 and Exendin-4, but exhibited a significantly reduced β-arrestin response. …”
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    Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects
  19. 1039
    “…Uptake of a promising radiotracer for β-cell imaging by SPECT, (111)In-exendin-3, was measured by ex vivo-SPECT and cross evaluated by 3D quantitative OPT imaging as well as with histology within healthy and alloxan-treated Brown Norway rat pancreata. …”
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    SPECT-OPT multimodal imaging enables accurate evaluation of radiotracers for β-cell mass assessments
  20. 1040
    “…In the current study, the barrier protective and anti-inflammatory properties of exendin-4 (Ex-4), an analog of GLP-1, after ischemia-reperfusion (IR) injury were examined. …”
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    Protective Effect of a GLP-1 Analog on Ischemia-Reperfusion Induced Blood–Retinal Barrier Breakdown and Inflammation
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