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1041“…Liver biopsy showed the lesions to be well-differentiated neuroendocrine tumors, grade G1. (68)Gallium-exendin-4 positron emission tomography/CT confirmed the origin as the lesion located at the jejunum. …”
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1042“…Following GTT protocol optimization the effect of exendin‐4 and metformin was equivalent in both sexes, with females showing a more modest but more reproducible GTT response. …”
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1043
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1044por Lee, Yeon-Kyeong, Lee, Ki Won, Kim, Minju, Lee, Yerin, Yoo, Jiyun, Hwangbo, Cheol, Park, Ki Hun, Kim, Kwang Dong“…(family Papaveraceae), commonly known as greater celandine or tetterwort, has been reported to have antibacterial and anticancer effects and chelidonine is known as a functional metabolite extracted from C.…”
Publicado 2019
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1045por Abdesselam, Inès, Pepino, Pauline, Troalen, Thomas, Macia, Michael, Ancel, Patricia, Masi, Brice, Fourny, Natacha, Gaborit, Bénédicte, Giannesini, Benoît, Kober, Frank, Dutour, Anne, Bernard, Monique“…Furthermore, mice treated with exendin-4 (30 μg/kg SC BID) after 4 months of diet were explored before and 14 days post-treatment with multimodal CMR. …”
Publicado 2015
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1046“…In the light of theranostics/radiotheranostics and prospective of personalized medicine in diabetes and oncology, this review presents prior and current advances in the development of radiolabeled imaging and radiotherapeutic exendin-based agents targeting glucagon-like peptide-1 receptor. …”
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1047por Yingyue, Quan, Sugawara, Kenji, Takahashi, Harumi, Yokoi, Norihide, Ohbayashi, Kento, Iwasaki, Yusaku, Seino, Susumu, Ogawa, Wataru“…Imeglimin enhanced GSIS in an additive manner with GLP‐1, but not with GIP, in mouse islets. Exendin‐9 had only a minor inhibitory effect on the glucose‐lowering action of imeglimin during the OGTT in KK‐Ay mice. …”
Publicado 2023
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1048“…METHODS: LDLR-KO mice were randomly treated with normal saline, liraglutide, or liraglutide plus a GLP-1R antagonist exendin-9 for four weeks. In parallel, HUVECs were cultured with ox-LDL alone or combined with liraglutide, in the presence or absence of lectin-like ox-LDL receptor-1(LOX-1) overexpression or GLP-1R knockdown. …”
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1049por Cabou, Cendrine, Campistron, Gérard, Marsollier, Nicolas, Leloup, Corinne, Cruciani-Guglielmacci, Celine, Pénicaud, Luc, Drucker, Daniel J., Magnan, Christophe, Burcelin, Rémy“…RESEARCH DESIGN AND METHODS— Awake free-moving mice were infused with the GLP-1 receptor agonist exendin-4 (Ex4) into the lateral ventricle of the brain in the basal state or during hyperinsulinemic eu-/hyperglycemic clamps. …”
Publicado 2008
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1050“…Simultaneous bath perfusion of 5 nM GLP-1 plus 100 nM Exendin (9-39), a GLP-1 receptor antagonist, was unable to block the GLP-1-induced increase in I(Ca); however, the increase in I(Ca )was abolished if Exendin (9-39) was pre-applied 5 min prior to GLP-1 administration. …”
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1051“…Receptor selectivity was tested by the simultaneous presence of a GLP1 receptor antagonist (exendin (9-39) amide) or a VIP receptor antagonist (hybrid of neurotensin 6-11 and VIP 7-28). …”
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1052por Kang, Guoxin, Chepurny, Oleg G, Rindler, Michael J, Collis, Leon, Chepurny, Zina, Li, Wen-hong, Harbeck, Mark, Roe, Michael W, Holz, George G“…This sensitizing action of exendin-4 is diminished by an inhibitor of PKA (H-89) or by overexpression of dominant negative Epac. …”
Publicado 2005
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1053por Hectors, Tine L. M., Vanparys, Caroline, Pereira-Fernandes, Anna, Martens, Geert A., Blust, Ronny“…After optimization of exposure conditions, positive (exendin-4, glibenclamide) and negative (diazoxide) control compounds for acute insulin secretion responses were tested and those with the most profound effects were selected to allow potency estimations and ranking of pollutants. …”
Publicado 2013
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1054por Sélley, Eszter, Kun, Szilárd, Szijártó, István András, Laczy, Boglárka, Kovács, Tibor, Fülöp, Ferenc, Wittmann, István, Molnár, Gergő A“…BACKGROUND: It has been reported that GLP-1 agonist exenatide (exendin-4) decreases blood pressure. The dose-dependent vasodilator effect of exendin-4 has previously been demonstrated, although the precise mechanism is not thoroughly described. …”
Publicado 2014
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1055por Jin, Long, Lim, Sun Woo, Doh, Kyoung Chan, Piao, Shang Guo, Jin, Jian, Heo, Seong Beom, Chung, Byung Ha, Yang, Chul Woo“…MK-0626 treatment restored the expression of GLP-1R, and direct administration of exendin-4 to isolated islets reduced TAC-induced cell death and 8-OHdG expression. …”
Publicado 2014
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1056por Yin, Yanting, Zhou, X Edward, Hou, Li, Zhao, Li-Hua, Liu, Bo, Wang, Gaihong, Jiang, Yi, Melcher, Karsten, Xu, H Eric“…In contrast to this model, here we demonstrate that glucagon-like peptide-1 receptor can be activated by N-terminally truncated glucagon-like peptide-1 or exendin-4 when fused to the receptor, raising the question regarding the role of N-terminal residues of peptide hormone in glucagon-like peptide-1 receptor activation. …”
Publicado 2016
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1057por Kumar, Sunil, Lau, Raymond, Palaia, Thomas, Hall, Christopher, Lee, Jenny, Hall, Keneth, Brathwaite, Collin E., Ragolia, Louis“…OBJECTIVE: To validate the beneficial GLP-1 mediated cardiometabolic effects post VSG using GLP-1 antagonist (exendin 9-39) in Zucker diabetic fatty rats. METHODS: Animals were divided into three (n = 5) groups: (i) sham, (ii) VSG, and (iii) VSG received exendin 9–39 (GLP-1 receptor antagonist). …”
Publicado 2016
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1058“…Besides that, intraperitoneal injection of exendin-(9–39) was performed at day 1 and 4 after model construction. …”
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1059por Wang, Jingjing, Yu, Min, Xu, Jian, Cheng, Yusheng, Li, Xiang, Wei, Guihong, Wang, Hong, Kong, Hui, Xie, Weiping“…RESULTS: In the present study, GLP-1 receptor antagonist (exendin-3) abolished the protective effects of DPP-4 inhibitor (sitagliptin) on right ventricular systolic pressure (RVSP) and pulmonary vascular remodeling (PVR) in monocrotaline (MCT, 60 mg/kg)-induced PH in rat. …”
Publicado 2019
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1060por Zhang, Zhen, Hu, Yinghui, Xu, Ningning, Zhou, Wenjun, Yang, Lei, Chen, Rongping, Yang, Rui, Sun, Jia, Chen, Hong“…In the present study, we adopted single high-dose (60 mg/kg, i.p.) streptozotocin (STZ) to model diabetes mellitus (DM) and randomly assigned short-tail (SD) rats to a normal group, a diabetic group, GLP1 groups (50 μg/kg, 100 μg/kg, and 200 μg/kg), a GLP1 (200 μg/kg) with exendin (9-39) group, and a GLP1 with LY294002 group. …”
Publicado 2019
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