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  1. 1061
    “…METHODS: Cytokine array kit was used to assess cytokine profiles in db/db mice and mouse primary hepatocytes treated with exenatide (exendin-4). Two diabetic mouse models (db/db and Pax6(m/+)) were treated with a GLP-1 analog exenatide or liraglutide. …”
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    Liver-derived fibroblast growth factor 21 mediates effects of glucagon-like peptide-1 in attenuating hepatic glucose output
  2. 1062
    “…Here we combine cryo-electron microscopy, molecular dynamics simulations, receptor mutagenesis and pharmacological assays, to interrogate the mechanism and consequences of GLP-1R binding to four peptide agonists; glucagon-like peptide-1, oxyntomodulin, exendin-4 and exendin-P5. These data reveal that distinctions in peptide N-terminal interactions and dynamics with the GLP-1R transmembrane domain are reciprocally associated with differences in the allosteric coupling to G proteins. …”
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    Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
  3. 1063
    por Stayte, Sandy, Vissel, Bryce
    Publicado 2017
    “…This scientific commentary refers to ‘Insulin resistance and exendin-4 treatment for multiple system atrophy’, by Bassil et al., (doi:10.1093/brain/awx044).…”
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    New hope for devastating neurodegenerative disease
  4. 1064
    “…The liraglutide antagonist exendin (9–39) reversed the promoting effects of liraglutide on human umbilical vein endothelial cell functions. …”
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    Liraglutide Accelerates Ischemia‐Induced Angiogenesis in a Murine Diabetic Model
  5. 1065
    “…This effect was wholly abolished in macrophages pretreated with exendin(9−39) or (Pro(3))GIP, or with an adenylate cyclase inhibitor, MDL12,330A, and was mimicked by incubation with an adenylate cyclase activator, forskolin. …”
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    Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice
  6. 1066
    “…When the rats were given a choice between palatable food and chow, intra-NTS Exendin-4 treatment preferentially reduced intake of palatable food but not chow. …”
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    Activation of the GLP-1 Receptors in the Nucleus of the Solitary Tract Reduces Food Reward Behavior and Targets the Mesolimbic System
  7. 1067
    “…N55 was found to dose-dependently lower plasma glucose in non-fasted mice but not in the fasted mice, with the effect attenuated by GLP-1R antagonist exendin-(9–39) (Ex-9). On the other hand, when co-administered with dipeptidyl peptidase-IV (DPP4) -resistant [Aib8]-GLP-1(7–36) amide (GLP-1′), hypoglycemic response to N55 was observed in the fasted mice. …”
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    Fenugreek Compound (N55) Lowers Plasma Glucose through the Enhancement of Response of Physiological Glucagon-like peptide-1
  8. 1068
    “…Insulin secretion from pancreatic islets was concentration-dependent with human GLP-1, but not the synthetic analogue exendin-4. The GLP-1R antagonist exendin 9-39 (1 nM) reduced (P = 0.08) insulin secretion by 27%. …”
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    Equine glucagon-like peptide-1 receptor physiology
  9. 1069
    “…In additional experiments, effects of exendin‐4 in mice and of anagliptin in DPP‐4‐deficient rats were assessed. …”
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    Dipeptidyl peptidase 4 inhibitor anagliptin ameliorates hypercholesterolemia in hypercholesterolemic mice through inhibition of intestinal cholesterol transport
  10. 1070
    “…Furthermore, exendin-4 blocked (p < 0.05) LPS-induced inflammation in human adipocytes via downregulating the expression and secretion of key inflammatory markers. …”
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    GLP-1 Limits Adipocyte Inflammation and Its Low Circulating Pre-Operative Concentrations Predict Worse Type 2 Diabetes Remission after Bariatric Surgery in Obese Patients
  11. 1071
    “…RESULTS: Insulin secretion under the 16.7 mM glucose plus exendin-4 condition was mapped significantly to a chromosome 2 QTL. …”
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    A genetic screen identifies Crat as a regulator of pancreatic beta-cell insulin secretion
  12. 1072
    “…Therefore, we tested the effects of exendin-9, a GLP-1R antagonist. Exendin-9 was shown to reduce GSIS by 39% and 61% in ND islets and T2D islets, respectively. …”
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    Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes
  13. 1073
    “…Co-administration of exendin 9-39, a GLP-1R antagonist, did not prevent liraglutide- or semaglutide-induced effects in this study. …”
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    Long-Acting Glucagon-Like Peptide-1 Receptor Agonists Suppress Voluntary Alcohol Intake in Male Wistar Rats
  14. 1074
    “…The effect of insulin and an incretin analogue, exendin-4 on insulin signaling was also examined by assessing glycogen synthase kinase-3 (GSK-3) phosphorylation. …”
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    The Impact of Differentiation on Cytotoxicity and Insulin Sensitivity in Streptozotocin Treated SH-SY5Y Cells
  15. 1075
    Tabla de Contenidos: “…Kantate No. 7: Crist, unser Herr, zum Jordan kam -- Kantate No. 13: Meine Seufzer, meine Tränen -- Kantate No. 17: Wer Dank opfert, der preiset -- Kantate No. 20: O Ewigkeit, du Donnerwort -- Kantate No. 65: Sie werden aus Saba alle kommen -- Kantate No. 75: Die Elenden sollen essen -- Kantate No. 85: Ich bin ein guter Hirt -- Kantate No. 87: Bisher habt ihr nichts gebeten -- Kantate No. 93: Wer nur den lieben Gott läbt walten -- Kantate No. 95: Christus, der ist mein Leben -- Kantate No. 134: Ein Herz, das seinen Jesum -- Kantate No. 153: Schau, lieber Gott -- Kantate No. 161: Komm, du sube Todesstunde -- Kantate No. 167: Ihr Menschen, rühmt Gottes -- Oster-Oratorium.…”
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    Fünfzehn Arien aus Kantaten für Tenor
  16. 1076
    “…The GLP-1-induced enhancement of evoked EPSCs was abolished by a selective GLP-1 receptor antagonist, exendin 9–39, as well as by the extracellular application of a specific protein kinase A (PKA) inhibitor, KT5720. …”
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    Glucagon-like peptide-1 facilitates cerebellar parallel fiber glutamate release through PKA signaling in mice in vitro
  17. 1077
    “…Conversely high glucose, expression of a constitutively active PKA subunit, or exposure to exendin-4 or forskolin led to GLP-1R-GFP internalization. …”
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    Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic β-cells via protein kinase A
  18. 1078
    por Wang, Yan-Gui, Yang, Tian-Lun
    Publicado 2015
    “…The cells were incubated with oxLDL (50 µg/mL), liraglutide (0.1, 0.5, 1 and 2 nmol/L) or exendin-3 (9-39) (1, 10 and 100 nmol/L) alone, or in combination. …”
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    Liraglutide reduces oxidized LDL-induced oxidative stress and fatty degeneration in Raw 264.7 cells involving the AMPK/SREBP1 pathway
  19. 1079
    “…Furthermore, the biological effects of SCD are stronger than Exendin-4 (a clinically approved drug through its insulinotropic effect), DBAYL, SeNPs or SC. …”
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    A novel selective VPAC2 agonist peptide-conjugated chitosan modified selenium nanoparticles with enhanced anti-type 2 diabetes synergy effects
  20. 1080
    “…Furthermore, Mdr2(−/−) mice as well as wild-type 3,5-diethoxy-carbonyl-1,4-dihydrocollidine-fed mice were treated with GLP-1-receptor agonist exendin-4 for 2 weeks prior to analysis. RESULTS: Colesevelam reduced serum liver enzymes, BAs and expression of proinflammatory and profibrogenic markers. …”
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    Colesevelam attenuates cholestatic liver and bile duct injury in Mdr2(−/−) mice by modulating composition, signalling and excretion of faecal bile acids
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