“…RESULTS: SuM microinjections of the GLP-1 analogue, exendin-4, reduced ad libitum intake of chow, fat, or sugar solution in both male and female rats, while food-motivated behaviors, measured using the sucrose motivated operant conditioning test, was only reduced in male rats. …”
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“…Treatment of cells exposed to TM or high-dextrose with the GLP1R agonists GLP1, exendin 4, liraglutide, albiglutide, and lixisenatide resulted in a dose-dependent decrease in ER stress. …”
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“…Some of these peptides, including somatostatin, bombesin, vasoactive intestinal peptide, gastrin, neurotensin, exendin and RGD are currently under investigation. …”
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“…Common adverse effects include peripheral oedema, hyperuricaemia, and hirsutism. (68)Ga-NOTA-exendin-4 PET/CT scan should be considered for insulinoma localisation when other modalities have been unhelpful.…”
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“…Glucagon‐like peptide‐1 (GLP‐1) receptor‐targeted imaging such as that using [(18)F]FB(ePEG12)12‐exendin‐4 positron emission tomography (PET) is promising and may fill unmet clinical needs.…”
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“…In db/db mice, a model of diabetes, GSK457 (10% w/w) combined with the exendin-4 AlbudAb reduced glucose by 217 mg/dL and HbA1c by 1.2% after 14 days. …”
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“…Finally, the effects of treatment with insulin, exendin-4, and leptin on blood glucose were then compared in Akita mice. …”
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“…In the other two OGTT sessions, rats were treated with either Exendin (9–39) (GLP-1 antagonist) or Exendin (9–39) plus IES to investigate the underlying mechanism involving GLP-1. …”
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“…RESULTS: The cardioprotective effects of endogenous GLP-1 were impaired in diabetic mice after myocardial IRI and administration of exendin-4 had no significant effects in restoring cardiac function. …”
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“…Amitozyn (Am) is a semi-synthetic drug produced by the alkylation of major celandine (Chelidonium majus L.) alkaloids with the organophosphorous compound N,N’N’-triethylenethiophosphoramide (ThioTEPA). …”
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“…A MC target for the peptide was determined using GLP‐1 receptor binding assays, immunocytochemistry for the receptor and injection of fluorescence‐labelled GLP‐1 analogue exendin‐4. Using patch clamp recording of olfactory bulb slices in the whole‐cell configuration, we report that GLP‐1 and its stable analogue exendin‐4 increase the action potential firing frequency of MCs by decreasing the interburst interval rather than modifying the action potential shape, train length or interspike interval. …”
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“…From the three (68)Ga-radiopharmaceuticals tested, only in the [(68)Ga]Ga-NODAGA-Exendin samples exceeding amounts of HEPES were found and its concentration in the [(68)Ga]Ga-NODAGA-Exendin was significantly higher, when compared to [(68)Ga]Ga-DOTATOC and [(68)Ga]Ga-PSMA-11. …”
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“…Eur. limit, especially for [(68)Ga]Ga-NODAGA-Exendin-4. Conclusions: The TLC method that is described in Ph. …”
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“…They can be broadly classified as exendin-based therapies (exenatide, exenatide once weekly), DPP-4-resistant analogues (lixisenatide, albiglutide), and analogues of human GLP-1 (liraglutide, taspoglutide). …”
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“…Growth factors activin A, retinoic acid, nicotinamide, Exendin-4 and betacellulin were added sequentially to the hpES cells at each step. …”
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“…GSPE components act by activating the Glucagon-like peptide-1 (GLP-1) receptor because their effect is blocked by Exendin 9-39. GSPE in turn acts on the hypothalamic center of food intake control probably because of increased GLP-1 production in the intestine. …”
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“…Of these, three variants originated from the Papaveraceae species (oilseed poppy, common poppy and great celandine), previously poorly described as CMV natural hosts. …”
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“…Rat pancreatic islets were incubated in different concentrations glucose solutions, with cinchonine or Exendin (9–39) added to determine insulin secretion levels. …”
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“…GLP-1R agonists, such as exendin-4, are particularly useful for benign insulinoma detection, but their accuracy decreases in the case of malignant insulinomas. …”
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“…Reseña de: CARPALLO BAUTISTA, ANTONIO Y VÉLEZ CELEMÍN, ANTONIO. Los papeles decorados en las encuadernaciones del Archivo y Biblioteca de la Catedral de Toledo. …”
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