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1101por Gallwitz, Baptist“…Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) were introduced for type 2 diabetes therapy nearly 10 years ago, among them short-acting compounds on the basis of the GLP-1-like peptide exendin-4 (exenatide and lixisenatide) and a long-acting GLP-1 RA based on the human GLP-1 sequence (liraglutide). …”
Publicado 2015
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1102por Sancandi, Marco, Schul, Emma Victoria, Economides, Georgia, Constanti, Andrew, Mercer, Audrey“…These changes were prevented by treatment with a neuroprotective drug, a glucagon-like peptide-1 (GLP1) receptor agonist, exendin-4 (EX-4).…”
Publicado 2018
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1103por Amatya, Reeju, Park, Taehoon, Hwang, Seungmi, Yang, JaeWook, Lee, Yoonjin, Cheong, Heesun, Moon, Cheol, Kwak, Hyun Duck, Min, Kyoung Ah, Shin, Meong Cheol“…We focus our research on the strategies that have been successfully applied to improve the plasma half-life of exendin-4, a clinically available toxin-derived anti-diabetic peptide drug.…”
Publicado 2020
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1104“…Some CPPs have been applied for the delivery of peptide antidiabetics, including insulin and exendin-4, for treating diabetes and Alzheimer’s disease. …”
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1105“…The results demonstrated that the two polymer films displayed well-defined redox peaks in pairs during the p-type doping, and showed distinct color change from dark gray blue to light green for P(TBT-TBTh) with the band gap of 1.51 eV, and from gray blue to celandine green for P(TBT-F-TBTh) with the band gap of 1.58 eV. …”
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1106por Yamada, Takayuki, Wakabayashi, Mako, Bhalla, Abhinav, Chopra, Nitin, Miyashita, Hirotaka, Mikami, Takahisa, Ueyama, Hiroki, Fujisaki, Tomohiro, Saigusa, Yusuke, Yamaji, Takahiro, Azushima, Kengo, Urate, Shingo, Suzuki, Toru, Abe, Eriko, Wakui, Hiromichi, Tamura, Kouichi“…Among GLP-1 RAs, GLP-1 analogues showed a positive impact on cardiovascular and renal outcomes, while exendin-4 analogues did not.…”
Publicado 2021
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1107por Nock, Berthold A., Kanellopoulos, Panagiotis, Joosten, Lieke, Mansi, Rosalba, Maina, Theodosia“…Likewise, the pursuit of gastrin and exendin antagonist-based radioligands is advancing with exciting new outcomes on the horizon. …”
Publicado 2023
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1108“…Exenatide (also known as exendin-4) is a glucagon-like peptide-1 mimetic, which is indicated for the treatment of type 2 diabetes mellitus. …”
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1109por Clardy, Susan M., Mohan, James F., Vinegoni, Claudio, Keliher, Edmund J., Iwamoto, Yoshiko, Benoist, Christophe, Mathis, Diane, Weissleder, Ralph“…We developed a fluorescent exendin-4-like neopeptide conjugate for the rapid purification and isolation of functional mouse pancreatic β-cells. …”
Publicado 2015
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1110“…Blockade of the GLP-1 receptor with Exendin 9–39 does not block the increase in oxygen consumption caused by OX-SR. …”
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1111por Larraufie, Pierre, Roberts, Geoffrey P., McGavigan, Anne K., Kay, Richard G., Li, Joyce, Leiter, Andrew, Melvin, Audrey, Biggs, Emma K., Ravn, Peter, Davy, Kathleen, Hornigold, David C., Yeo, Giles S.H., Hardwick, Richard H., Reimann, Frank, Gribble, Fiona M.“…Here, we show that GLP-1 is a major driver of insulin secretion after bariatric surgery, as demonstrated by blocking GLP-1 receptors (GLP1Rs) post-gastrectomy in lean humans using Exendin-9 or in mice using an anti-GLP1R antibody. …”
Publicado 2019
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1112por Shmool, Talia A., Hooper, Philippa J., Kaminski Schierle, Gabriele S., van der Walle, Christopher F., Zeitler, J. Axel“…Using Fourier transform infrared spectroscopy measurements in the mid-infrared, we were able to characterize the interactions between a model polypeptide, exendin-4, and the PLGA copolymer. We observe a relationship between the experimentally determined [Formula: see text] and [Formula: see text] and free volume and microsphere dynamics.…”
Publicado 2019
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1113“…Targeting GLP-1R with indium-111, technetium-99m or gallium-68-labeled exendin-4 offers a new approach that permits the successful localization of small benign insulinomas. …”
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1114“…Studies which assess the role of gut hormones after bariatric surgery on food intake, hunger, satiety and glucose homeostasis through octreotide use (a non-specific inhibitor of gut hormone secretion) as well as with exendin 9–39 (a specific glucagon-like peptide-1 receptor antagonist) are reviewed. …”
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1115Deoxynivalenol (Vomitoxin)-Induced Anorexia Is Induced by the Release of Intestinal Hormones in Micepor Yue, Jianming, Guo, Dawei, Gao, Xiuge, Wang, Jiacai, Nepovimova, Eugenie, Wu, Wenda, Kuca, Kamil“…Furthermore, the PYY receptor antagonist JNJ-31020028, GLP-1 receptor antagonist Exendin(9-39), CCK receptor antagonist Proglumide, GIP receptor antagonist GIP(3-30)NH(2) attenuated both intestinal hormone and DON-induced anorectic responses. …”
Publicado 2021
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1116“…This review highlights advancements in venom-derived compounds for the treatment of diabetes and related disorders. Exendin-4, originating from the saliva of Gila monster lizard, represents proof-of-concept for this drug discovery pathway in diabetes. …”
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1117por Ábrahám, Ágnes, Massignan, Flavio, Gyulai, Gergő, Katona, Miklós, Taricska, Nóra, Kiss, Éva“…Amyloids have been prepared from two proteins, lysozyme and β-lactoglobulin, as well as an Exendin-4 derivative miniprotein (E5). Thermal treatment was applied to form amyloids and their structure was verified by thioflavin T (ThT), 8-Anilino-1-naphthalenesulfonic acid (ANS) dye tests and electronic circular dichroism spectroscopy (ECD). …”
Publicado 2022
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1118“…By using the figures of Fricke and McClendon for the thickness of the membrane of the red blood cell some comparisons were drawn between the dried collodion membrane as a model for certain biological membranes and the red blood cell membrane. …”
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1119“…Targeting GLP-1R with the stable GLP-1 analogs (111)In-DOTA/DPTA-exendin-4 offers a new approach to successfully localize these small tumors. …”
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1120por Meng, Jingru, Ma, Xue, Wang, Ning, Jia, Min, Bi, Long, Wang, Yunying, Li, Mingkai, Zhang, Huinan, Xue, Xiaoyan, Hou, Zheng, Zhou, Ying, Yu, Zhibin, He, Gonghao, Luo, Xiaoxing“…Here, we show that the GLP-1 receptor agonist exendin-4 (Ex-4) promoted bone formation and increased bone mass and quality in a rat unloading-induced bone loss model. …”
Publicado 2016
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