Materias dentro de su búsqueda.
Materias dentro de su búsqueda.
Educación
22
Filosofía de la educación
9
Métodos experimentales
8
Estudio y enseñanza
7
Escuelas públicas
5
Educación primaria
4
Inglés
4
Desarrollo infantil
3
Educación del oído
3
Estudiantes extranjeros
3
Niños
3
Problemas, ejercicios, etc
3
Psicología infantil
3
Teoría musical
3
Educación moral
2
Enseñanza
2
Estudio y enseñanza (Superior)
2
Francés
2
Lectura (Educación superior)
2
Lectura musical
2
Literatura española
2
Medicina
2
Música
2
Novela estadounidense
2
Planificación curricular
2
Psicopedagogía
2
Servicios al cliente
2
Apreciación musical
1
Aritmética
1
Cantatas, música sacra (tenor) con piano
1
-
1121“…The advent of incretin-based therapy, whether by increasing endogenous glucagon-like peptide (GLP)-1 and glucose-dependent inhibitory polypeptide by inhibition of their breakdown using di-peptidyl peptidase 4 inhibitors, or augmenting GLP-1 activity using either exendin-4-based drugs or synthetic GLP-1 analogs promised not just improvements in glycemic control, but improvements in endothelial function, lipid profiles and markers of vascular inflammation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1122“…In addition, arachidonyl-2’-chloroethylamide (ACEA), carbachol, chemokine (C-C motif) ligand-5 (CCL5), and exendin as well as phorbol myristate acetate (PMA) ligands showed significant increases in the insulin secretion of MIN6 pancreatic β-cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1123“…The peptide-based therapy for Huntington's disease includes both poly Q peptide as well as non poly Q peptides like (QBP1)2, p42, Exendin 4, ED11, CaM, BiP, Leuprorelin peptide. The novel approach that is currently being tested in this article is the peptide-based therapy to target the mutated protein. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1124por Milliken, Brandon T., Elfers, Clinton, Chepurny, Oleg G., Chichura, Kylie S., Sweet, Ian R., Borner, Tito, Hayes, Matthew R., De Jonghe, Bart C., Holz, George G., Roth, Christian L., Doyle, Robert P.“…This study developed monomeric peptide agonists of glucagon-like peptide 1 receptor (GLP-1R) and neuropeptide Y2 receptor (Y2-R) based on exendin-4 (Ex-4) and PYY(3–36). A novel peptide, GEP44, was obtained via in vitro receptor screens, insulin secretion in islets, stability assays, and in vivo rat and shrew studies of glucoregulation, weight loss, nausea, and emesis. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1125por Tu, Yuanyuan, Li, Lele, Zhu, Linling, Guo, Yang, Du, Shu, Zhang, Yuxing, Wang, Zhenzhen, Zhang, Yuting, Zhu, Manhui“…We found that GEN inhibited ROS accumulation, NF-κB activation, Müller cell activation, and inflammatory cytokine secretion both in vitro and in vivo, which is probably mediated through the Nrf2 pathway. Exendin (9-39) (EX-9), an antagonist of glucagon-like peptide-1 receptor (GLP-1R), abolished the protective effect of GEN on high glucose- (HG-) induced Müller cells. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1126por Hurtado-Carneiro, Verónica, Dongil, Pilar, Pérez-García, Ana, Álvarez, Elvira, Sanz, Carmen“…The current knowledge would suggest that PASK inhibition and/or exendin-4 treatment, especially under fasting conditions, could ameliorate disorders associated with excess oxidative stress.…”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1127por Jović, Marko D., Agatonovic-Kustrin, Snezana, Ristivojević, Petar M., Trifković, Jelena Đ., Morton, David W.“…Furthermore, green tea, greater celandine, and fumitory extracts exhibited pronounced potential in suppressing COX-1 activity. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1128“…The greater celandine ‘Chelidonium majus’ and its main alkaloid chelidonine have previously been shown to exert high cytotoxicity against cancer cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1129por Dieterle, Martin Philipp, Husari, Ayman, Prozmann, Sophie Nicole, Wiethoff, Hendrik, Stenzinger, Albrecht, Röhrich, Manuel, Pfeiffer, Uwe, Kießling, Wolfgang Rüdiger, Engel, Helena, Sourij, Harald, Steinberg, Thorsten, Tomakidi, Pascal, Kopf, Stefan, Szendroedi, Julia“…Upon imaging studies, no tumor mass potentially indicating insulinoma could be detected. (68)Ga-DOTA-Exendin-4 PET/CT showed diffuse tracer enrichment throughout the whole pancreas. …”
Publicado 2023
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1130por Sandoval, Darleen, Barrera, Jason G., Stefater, Margaret A., Sisley, Stephanie, Woods, Stephen C., D’Alessio, David D., Seeley, Randy J.“…To examine the role of glucokinase, an important CNS glucose sensor, we studied glucokinase-heterozygous knockout mice, but found that they responded normally to peripherally administered GLP-1 and exendin-4. Interestingly, oral, but not i3vt or IP glucose potentiated GLP-1′s anorectic action. …”
Publicado 2012
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1131por Kaihara, Kelly A., Dickson, Lorna M., Jacobson, David A., Tamarina, Natalia, Roe, Michael W., Philipson, Louis H., Wicksteed, Barton“…Acute-phase insulin secretion was increased 3.5-fold, reducing circulating glucose to 58% of levels in controls. Exendin-4 increased acute-phase insulin release to a similar degree as PKA activation. …”
Publicado 2013
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1132“…Importantly, lixisenatide causes a significant delay in gastric emptying time, an important determinant of the once-daily dosing regimen. An exendin-4 mimetic with six lysine residues removed at the C-terminal, lixisenatide has pronounced postprandial glucose-lowering effects, making it a novel incretin agent for use in combination with optimally titrated basal insulin. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1133por Wang, Ping, Yoo, Byunghee, Yang, Jingsheng, Zhang, Xueli, Ross, Alana, Pantazopoulos, Pamela, Dai, Guangping, Moore, Anna“…Toward this goal, we synthesized an exendin-4 conjugated magnetic iron oxide–based nanoparticle probe targeting glucagon-like peptide 1 receptor (GLP-1R), which is highly expressed on the surface of pancreatic β-cells. …”
Publicado 2014
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1134por Brand, Christian, Abdel-Atti, Dalya, Zhang, Yachao, Carlin, Sean, Clardy, Susan M., Keliher, Edmund J., Weber, Wolfgang A., Lewis, Jason S., Reiner, Thomas“…The conjugation of a bimodal imaging tag containing a near-infrared fluorescent dye, and the copper chelator sarcophagine to the GLP-1R targeting peptide exendin-4 provided the basis for the bimodal imaging probe. …”
Publicado 2014
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1135por Lutter, Michael, Bahl, Ethan, Hannah, Claire, Hofammann, Dabney, Acevedo, Summer, Cui, Huxing, McAdams, Carrie J., Michaelson, Jacob J.“…Administration of the glucagon-like peptide 1 receptor agonist exendin-4 significantly reduced food intake in a mouse model of ‘binge-like’ eating. …”
Publicado 2017
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1136por Kamei, Noriyasu, Tamiwa, Hideyuki, Miyata, Mari, Haruna, Yuta, Matsumura, Koyo, Ogino, Hideyuki, Hirano, Serena, Higashiyama, Kazuhiro, Takeda-Morishita, Mariko“…Furthermore, l-tryptophan exhibited the ability to greatly enhance the intestinal absorption of other peptide drugs such as glucagon-like peptide-1 (GLP-1), its analog Exendin-4 and macromolecular hydrophilic dextrans with molecular weights ranging from 4000 to 70,000 g/mol. …”
Publicado 2018
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1137“…Here, we identified that a T-UCR, uc.336-as, played an important role during the browning process. uc.336-as was significantly elevated during browning process induced by exendin-4 or β3-adrenergic agonist (CL316,243). Moreover, we found that uc.336-as promoted browning process and inhibited adipogenesis. …”
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1138por Hironao, Ken-yu, Mitsuhashi, Yuji, Huang, Shujiao, Oike, Hideaki, Ashida, Hitoshi, Yamashita, Yoko“…It was noteworthy that an antagonist for GLP-1 receptor Exendin (9-39) canceled CLPr-increased expression of Per family and Dbp and phosphorylation of AMPK in the liver, in addition to insulin secretion. …”
Publicado 2020
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1139por Costa, Alessia, Ai, Minrong, Nunn, Nicolas, Culotta, Isabella, Hunter, Jenna, Boudjadja, Mehdi Boutagouga, Valencia-Torres, Lourdes, Aviello, Gabriella, Hodson, David J., Snider, Brandy M., Coskun, Tamer, Emmerson, Paul J., Luckman, Simon M., D'Agostino, Giuseppe“…METHODS: We employed a combination of neuroanatomical, genetic, and behavioral approaches in the mouse to investigate the involvement of caudal brainstem cholecystokinin-expressing neurons in the effect of the GLP-1RA exendin-4. We further confirmed key neuroanatomical findings in the non-human primate brain. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
1140por Jolivalt, Corinne G., Han, May Madi, Nguyen, Annee, Desmond, Fiona, Alves Jesus, Carlos Henrique, Vasconselos, Daniela C., Pedneault, Andrea, Sandlin, Natalie, Dunne-Cerami, Sage, Frizzi, Katie E., Calcutt, Nigel A.“…Ocular delivery of the peptides ciliary neurotrophic factor (CNTF) or the glucagon-like peptide (GLP) analog exendin-4, both of which prevent diabetic neuropathy when given systemically, restored corneal nerve density within 2 weeks. …”
Publicado 2022
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto