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1141por Hölscher, Christian“…Importantly, the GLP-1 receptor agonists exendin-4 and liraglutide have shown good protective effects in clinical trials in AD and PD patients. …”
Publicado 2022
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1142por Galabov, Angel S.“…These include: hydrogen peroxide, hypochlorites, cupric and ferric ions, per-acids; ethanol, parachlorometaxylenol in a sodium C14-16 olefin sulfonate, glutaraldehyde, quaternary ammonium salts, chlorhexidine and chlorhexidine gluconate, curdline sulphate, glycerol, lipids, azodicarbonamide, cicloxolone sodium, dichlorisocyanuric acid (sodium salt), benzalkonium salts, disulfate benzamides and benzisothiazolones, congo red, ascorbic acid, nonoxynol-9, para-aminobenzoic acid, bis(monosuccinamide) derivative of p,p’-bis(2-aminoethyl) diphenlyi-C60) (fullerene). merocyanine, benzoporphyrin derivative monoacid ring A, rose bengal, hypericin, hypocrellin A, anthraquinones extracted from plants, sulfonated anthraquinones and other anthraquinone derivatives; gramicidine, gossypol, garlic (Allium sativum) extract and its components: ajoene, diallyl thiosulfinate (allicin), allyl methyl thioulfinate, methyl allyl thiosulfinate, extracts of ledium, motherworth, celandine, black currant, coaberry and bilberry, extract of Cordia salicifolia, steam distillate from Houttuynia cordata (Saururaceae) and its component, 5,6,7-trimethoxyflavone from Calicarpa japonica, isoscullarein (5,7,8,4’-tetrahydroxyflavone) from Scutellaria baikalensis and isoscutellarein-8-methylether, alkaloids and phytosteryl ester compounds.…”
Publicado 2007
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1143por Paczkowska, Magdalena, Chanaj-Kaczmarek, Justyna, Romaniuk-Drapała, Aleksandra, Rubiś, Błażej, Szymanowska, Daria, Kobus-Cisowska, Joanna, Szymańska, Emilia, Winnicka, Katarzyna, Cielecka-Piontek, Judyta“…Chelidonium majus (also known as celandine) contains pharmacologically active compounds such as isoquinoline alkaloids (e.g., chelidonine, sanguinarine), flavonoids, saponins, carotenoids, and organic acids. …”
Publicado 2020
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1144por Nurzhanova, Farida, Absatirov, Gaisa, Sidikhov, Bekzhasar, Sidorchuk, Alexander, Ginayatov, Nurbek, Murzabaev, Kenzhebek“…This study explored the vulnerary effect of botanical medicines made from local raw materials (greater celandine [Chelidonium majus L.], St. John’s wort [Hypericum perforatum L.], and bur beggar-ticks [Bidens tripartita L.]) in the treatment of sturgeon bacterial pathologies in a controlled environment. …”
Publicado 2021
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1145“…RESEARCH DESIGN AND METHODS: Twelve asymptomatic individuals with previous GB (Asym-GB), 10 matched healthy nonoperated control subjects, and 12 patients with recurrent hypoglycemia after GB (Hypo-GB) had pre- and postprandial hormone levels and insulin secretion rates (ISR) measured during a hyperglycemic clamp with either GLP-1 receptor blockade with exendin-(9–39) or saline. RESULTS: Blocking the action of GLP-1 suppressed postprandial ISR to a larger extent in Asym-GB individuals versus control subjects (33 ± 4 vs.16 ± 5%; P = 0.04). …”
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1146por Dames, P., Weise, M., Puff, R., Göke, B., Parhofer, K. G., Seissler, J., Lechner, A.“…Overexpression of Eny2 had no effect but siRNA-mediated knockdown of Eny2 resulted in markedly increased glucose and exendin-4-induced insulin secretion from otherwise poorly glucose-responsive INS-1E cells. …”
Publicado 2012
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1147“…RESULTS: Insulin nanomedicines based on alginate-dextran sulfate core with a chitosan-polyethylene glycol-albumin shell reduced glycaemia in a dose dependent manner. Orally available exendin-4 formulations exerted their effects in a time dependent manner. …”
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1148“…Compound 19e protected INS-1 cells from cytokine-induced cell death, and the effect was similar to treatment with another GKA or exendin-4. Compound 19e reduced annexin-V stained cells and the expression of cleaved caspase-3 and poly (ADP-ribose) polymerase protein, as well as upregulated the expression of B-cell lymphoma-2 protein. …”
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1149por Li, Laiyuan, Wang, Xiaolin, Bai, Liangliang, Yu, Huichuan, Huang, Zenghong, Huang, Anpei, Luo, Yanxin, Wang, Jianping“…Blood glucose levels expressed as a percentage of baseline were higher in SG rats than in control rats after exendin (9-39) administration (P < 0.05). The levels of GLP-1 expression in the jejunum and ileum were higher in SG rats than in PF-sham and control rats (P < 0.05). …”
Publicado 2018
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1150“…Co-treatment with glucagon and exendin-4 (Ex-4), a GLP-1 receptor agonist, additively increased glucose-stimulated insulin secretion in INS-1 cells. …”
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1151por Hornigold, David C., Roth, Emma, Howard, Victor, Will, Sarah, Oldham, Stephanie, Coghlan, Matthew P., Blouet, Clemence, Trevaskis, James L.“…In functional in vitro assays C2816 retained full agonism at GLP-1R and CCKR1 at lower potency compared to parent molecules, whereas a previously reported fusion peptide in the opposite orientation, (pGlu-Gln)-CCK-8/exendin-4, exhibited no activity at either receptor. …”
Publicado 2018
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1152por Hu, Zhenhua, Nizzero, Sara, Goel, Shreya, Hinkle, Louis E., Wu, Xiaoyan, Li, Chao, Ferrari, Mauro, Shen, Haifa“…We packaged LCFA-conjugated exendin-4 (LCFA-Ex4) into liposomes and coated with chitosan nanoparticles to form an orally deliverable Ex4 (OraEx4). …”
Publicado 2020
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1153por Kobashi, Motoi, Shimatani, Yuichi, Fujita, Masako, Mitoh, Yoshihiro, Yoshida, Ryusuke, Matsuo, Ryuji“…After the administration of a GLP-1 receptor antagonist (exendin-4(5-39)), an ineffective dose of orexin-A (0.3 nmol) suppressed reflex swallowing. (4) Conclusions: The presence of reciprocal inhibitory connections between GLP-1 receptive neurons and orexin-A receptive neurons in the NTS was strongly suggested.…”
Publicado 2020
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1154por White, Kate L., Singla, Jitin, Loconte, Valentina, Chen, Jian-Hua, Ekman, Axel, Sun, Liping, Zhang, Xianjun, Francis, John Paul, Li, Angdi, Lin, Wen, Tseng, Kaylee, McDermott, Gerry, Alber, Frank, Sali, Andrej, Larabell, Carolyn, Stevens, Raymond C.“…Our results show that glucose stimulation caused rapid changes in biochemical composition and/or density of insulin packing, increased mitochondrial volume, and closer proximity of insulin vesicles to mitochondria. Costimulation with exendin-4 (a glucagon-like peptide-1 receptor agonist) prolonged these effects and increased insulin packaging efficiency and vesicle maturation. …”
Publicado 2020
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1155por Zheng, Yizhou, Xiao, Yaosheng, Zhang, Di, Zhang, Shanshan, Ouyang, Jing, Li, Linfu, Shi, Weimei, Zhang, Rui, Liu, Hai, Jin, Qi, Chen, Zhixi, Xu, Daohua, Wu, Longhuo“…In addition, inhibition of ABAC1 expression reversed the actions of GEN. Treatment with Exendin9-39, a GLP-1R inhibitor, could abrogate the protective activity of GEN. …”
Publicado 2021
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1156“…In individuals with congenital hyperinsulinism due to inactivating mutations in the genes encoding the beta cell K(ATP) channels, the GLP-1 receptor antagonist, exendin-(9-39), increases fasting plasma glucose and prevents protein-induced hypoglycemia. …”
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1157“…It is noteworthy that TCTP-PTD and its variants promote intranasal delivery of antidiabetics including, insulin and exendin-4 and of antigens for immunization in vivo, suggesting its potential for drug delivery. …”
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1158por Prosperi, Daniela, Gentiloni Silveri, Guido, Panzuto, Francesco, Faggiano, Antongiulio, Russo, Vincenzo Marcello, Caruso, Damiano, Polici, Michela, Lauri, Chiara, Filice, Angelina, Laghi, Andrea, Signore, Alberto“…Other radiopharmaceuticals are (68)Ga-exendin-4 in case of insulinomas and (18)F-dopamine (DOPA), which can be helpful in SSTR-negative tumors. …”
Publicado 2022
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1159por Yang, Fan, Wang, Xinshang, Qi, Jingyu, Zhang, Kun, Jiang, Yongli, Feng, Ban, Lv, Tao, Yang, Le, Yang, Qi, Zhao, Minggao, Liu, Shuibing, Ma, Xue“…Thus, we aim to evaluate whether GLP-1R agonist exendin-4 (EX-4) could alleviate depression-like behaviors in diabetic mice and to explore its underlying mechanism. …”
Publicado 2022
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1160por Horváth, Dániel, Dürvanger, Zsolt, K. Menyhárd, Dóra, Sulyok-Eiler, Máté, Bencs, Fruzsina, Gyulai, Gergő, Horváth, Péter, Taricska, Nóra, Perczel, András“…We determine nine polymorphic crystal structures of the APR segments of glucagon-like peptides 1 and 2, and exendin and its derivatives. We follow amyloid formation by CD, FTIR, ThT assays, and AFM. …”
Publicado 2023
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