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1201“…BTC increased phosphorylation of ERK1/2, AKT, and mTOR and PC1/3 expression and GLP-1 production in α-cells, but BTC-induced proliferation was not changed by the GLP-1 receptor antagonist, exendin-9. We suggest that BTC has a direct role in α-cell proliferation via interaction with ErbB-3 and ErbB-4 receptors, and these increased α-cells might be a source of new β-cells.…”
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1202por Hernandez, Nicole S., Weir, Vanessa R., Ragnini, Kael, Merkel, Riley, Zhang, Yafang, Mace, Kyla, Rich, Matthew T., Pierce, R. Christopher, Schmidt, Heath D.“…Here, we showed that administration of the GLP-1R agonist exendin-4 (Ex-4) directly into the LDTg significantly attenuated cocaine seeking at a dose that did not affect sucrose seeking, ad libitum food intake or body weight. …”
Publicado 2020
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1203por Vestlund, Jesper, Bergquist, Filip, Licheri, Valentina, Adermark, Louise, Jerlhag, Elisabet“…Glucagon‐like peptide‐1 receptor (GLP‐1R) agonists, such as exendin‐4 (Ex4), liraglutide and dulaglutide, regulate glucose homeostasis and are thus used to treat diabetes type II. …”
Publicado 2020
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1204“…After PVN microinjection of fluorescent retrograde tracer followed by preparation of ex vivo rat brain slices, whole-cell patch clamp recordings were made in identified PVN-projecting neurons within the ventral alBST. Bath application of Exendin-4 (a specific GLP1R agonist) indirectly depolarized PVN-projecting neurons in the ventral alBST and adjacent hypothalamic parastrial nucleus (PS) through a network-dependent increase in excitatory synaptic inputs, coupled with a network-independent reduction in inhibitory inputs. …”
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1205por Homolak, Jan, Babic Perhoc, Ana, Knezovic, Ana, Osmanovic Barilar, Jelena, Salkovic-Petrisic, Melita“…Acute intracerebroventricular treatment with exendin-3(9-39)amide was used for pharmacological inhibition of brain GLP-1R in the control and STZ-icv rats, and oxidative stress was assessed in plasma, duodenum and ileum. …”
Publicado 2021
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1206por Lugo-Fabres, Pavel H., Otero-Sastre, Leslie M., Bernáldez-Sarabia, Johanna, Camacho-Villegas, Tanya A., Sánchez-Campos, Noemi, Serrano-Bello, Janeth, Medina, Luis A., Muñiz-Hernández, Saé, de la Cruz, Lizbeth, Arenas, Isabel, Barajas-Martínez, Antonio, Garcia, David E., Nuñez-Garcia, Linda, González-Canudas, Jorge, Licea-Navarro, Alexei F.“…The FDA’s approval of peptide drugs such as Ziconotide or Exendin for pain relief and diabetes treatment, respectively, enhanced the interest to explore novel conotoxins from Conus species venom. …”
Publicado 2021
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1207“…Seven days post PSNT, allodynia and hyperalgesia were confirmed as NP, and intrathecal (i.t) catheters were implanted and connected to an osmotic pump for the vehicle (1 μL/h) or TEN (5 μg/1 μL/h) or TEN (5 μg) + GLP-1R antagonist Exendin-3 (9–39) amide (EXE) 0.1 μg/1 μL/h infusion. …”
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1208“…Targeting the glucagon-like peptide-1 receptor by exendin-4 has a high sensitivity in localizing insulinomas. …”
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1209por Biagioli, Michele, Marchianò, Silvia, Roselli, Rosalinda, Di Giorgio, Cristina, Bellini, Rachele, Bordoni, Martina, Distrutti, Eleonora, Catalanotti, Bruno, Zampella, Angela, Graziosi, Luigina, Donini, Annibale, Fiorucci, Stefano“…In these models, ACE2 mRNA expression was further upregulated by GPABR1 agonism and reversed by exendin-3, a GLP-1 receptor antagonist. In in vitro studies, liraglutide, a GLP-1 analogue, increased the expression of ACE2 in colon epithelial cells/macrophages co-cultures. …”
Publicado 2022
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1210“…Using the commercially available antidiabetic drug exenatide (exendin-4) as a model peptide, we designed a novel exenatide derivative, termed LEX-1, comprising a 12-mer albumin-binding peptide, a protease-sensitive linker and a native exenatide. …”
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1211“…However, GLP-1 is rapidly degraded by dipeptdyl peptidase-IV (DPP-IV) to GLP-1 (9-36). Exendin-4 (Ex-4) is a DPP-IV-resistant GLP-1 receptor agonist which, when truncated to Ex-4 (9-39), acts as a GLP-1 receptor antagonist. …”
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1212por Zhang, Lingyu, Li, Chun, Zhang, Zijuan, Zhang, Zhenqiang, Jin, Qian-Qian, Li, Lin, Hölscher, Christian“…Two previous phase II trials in PD patients showed good effects with the older GLP-1 receptor agonists, exendin-4 and liraglutide. We have developed a dual GLP-1/GIP receptor agonist (DA5-CH) that can cross the blood-brain barrier (BBB) at a higher rate than semaglutide. …”
Publicado 2022
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1213“…INS1E cells were cultured in high glucose (HG, 20 mM) for 72 h or HG for an initial 24 h followed by drug addition (exendin-4, metformin and sodium salicylate) for the remaining 48 h. …”
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1214
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1215por Nawrot, Robert, Wolun-Cholewa, Maria, Bialas, Wojciech, Wyrzykowska, Danuta, Balcerkiewicz, Stanislaw, Gozdzicka-Jozefiak, Anna“…. & Koerte, the plant of numerous pharmacological activities, together with the studied earlier by our group Chelidonium majus L. (Greater Celandine), belong to the family Papaveraceae. The plant grows in Central and South Europe and produces the sizeable subterraneous tubers, empty inside, which are extremely resistant to various pathogen attacks. …”
Publicado 2010
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1216por Ballotin, Vinícius Remus, Bigarella, Lucas Goldmann, Brandão, Ajacio Bandeira de Mello, Balbinot, Raul Angelo, Balbinot, Silvana Sartori, Soldera, Jonathan“…He-Shou-Wu, Green tea extract, Herbalife, kava kava, Greater celandine, multiple herbs, germander, hydroxycut, skullcap, kratom, Gynura segetum, garcinia cambogia, ma huang, chaparral, senna, and aloe vera were the most common supplements with HILI reported. …”
Publicado 2021
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1217por Liu, Yang, Cao, Li-Xin, Wang, Wei-Yao, Piao, Yong-Rui, Wang, Jun-Ya, Chu, Chun-Ping, Bing, Yan-Hua, Qiu, De-Lai“…The GLP1 induced enhancement of membrane currents was also abolished by a selective GLP1 receptor antagonist, exendin-9-39, as well as by protein kinase A (PKA) inhibitors, KT5720 and H89. …”
Publicado 2023
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1218“…Toward that end, we systemically treated male and female C57BL/6 mice with the GLP-1R agonist exendin-4 (0.5 mg/kg, twice daily) or saline from postnatal day 14 to 21, then allowed uninterrupted development to adulthood. …”
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1219“…The GLP-1 receptor agonists used clinically are based on exendin-4 and native GLP-1 and are available as formulations for daily or weekly s.c. or oral administration. …”
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1220por Ghosh, Puja, Fontanella, Rosaria Anna, Scisciola, Lucia, Pesapane, Ada, Taktaz, Fatemeh, Franzese, Martina, Puocci, Armando, Ceriello, Antonio, Prattichizzo, Francesco, Rizzo, Maria Rosaria, Paolisso, Giuseppe, Barbieri, Michelangela“…Here we summarize the effects of GLP-1RAs against ROS overproduction and discuss the putative efficacy of Exendin-4, Lixisenatide, and Liraglutide in treating dementia by decreasing ROS.…”
Publicado 2023
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