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1301por Izumoto-Akita, Takako, Tsunekawa, Shin, Yamamoto, Akihito, Uenishi, Eita, Ishikawa, Kota, Ogata, Hidetada, Iida, Atsushi, Ikeniwa, Makoto, Hosokawa, Kaori, Niwa, Yasuhiro, Maekawa, Ryuya, Yamauchi, Yuichiro, Seino, Yusuke, Hamada, Yoji, Hibi, Hideharu, Arima, Hiroshi, Ueda, Minoru, Oiso, Yutaka“…STZ-induced diabetic male C57B/6J mice were injected with DMEM as a control, SHED-CM, exendin-4 (Ex-4), or BM-CM for 14 days. Mouse pancreatic β-cell line MIN6 cells were incubated with different concentrations of STZ with SHED-CM, DMEM, Ex-4, or BM-CM for 6 h. …”
Publicado 2015
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1302por Mohiuddin, Mohammad Sarif, Himeno, Tatsuhito, Inoue, Rieko, Miura-Yura, Emiri, Yamada, Yuichiro, Nakai-Shimoda, Hiromi, Asano, Saeko, Kato, Makoto, Motegi, Mikio, Kondo, Masaki, Seino, Yusuke, Tsunekawa, Shin, Kato, Yoshiro, Suzuki, Atsushi, Naruse, Keiko, Kato, Koichi, Nakamura, Jiro, Kamiya, Hideki“…We previously demonstrated that exendin-4 (Ex4), a glucagon-like peptide-1 receptor agonist (GLP-1RA), has beneficial effects in animal models of DPN. …”
Publicado 2019
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1303“…Although glucagon‐like peptide‐1 receptor (GLP‐1R) agonists, such as exendin‐4 (Ex‐4) and dulaglutide, are widely used for the treatment of diabetes, their effects on muscle pathology are unknown. …”
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1304“…GLP-1 receptor agonists (GLP-1 RA) are peptide derivatives of either exendin-4 or human GLP-1 designed to resist the activity of DPP-4 and therefore, have a prolonged half-life. …”
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1305“…Application of the GLP-1 receptor antagonist, Exendin-3-(9-39) (1 μM), prior to the photo-stimulation, abolished the facilitatory effect. …”
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1306“…Despite having increased circulating incretins, GIRKO mice had impaired oral glucose tolerance and limited glucose-lowering benefit from Exendin-4 (Ex-4) injections. Since HFD promotes inflammation in the gastrointestinal (GI) tract, we performed gene expression analysis and pathway analysis of duodenal mRNAs to investigate whether inflammatory response, glucose transport, and lipid transport were altered in HFD-fed GIRKO mice. …”
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1307por Singh, Ishnoor, Wang, Le, Xia, Baijuan, Liu, Ji, Tahiri, Azeddine, El Ouaamari, Abdelfattah, Wheeler, Michael B., Pang, Zhiping P.“…Application of GLP-1R specific agonist Exendin-4 (Exn-4) enhanced a proportion of the ARC GLP-1R-expressing neurons and pro-opiomelanocortin (POMC) neuronal action potential firing rates. …”
Publicado 2022
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1308por Nunn, Nicolas, Feetham, Claire H, Martin, Jennifer, Barrett-Jolley, Richard, Plagge, Antonius“…In contrast, atropine and exendin-4, a centrally acting agonist of the glucagon-like peptide-1 receptor, which influences cardiovascular physiology and metabolism, reduced HF power equally in both genotypes. …”
Publicado 2013
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1309por ten Kulve, Jennifer S., Veltman, Dick J., van Bloemendaal, Liselotte, Barkhof, Frederik, Deacon, Carolyn F., Holst, Jens J., Konrad, Robert J., Sloan, John H., Drent, Madeleine L., Diamant, Michaela, IJzerman, Richard G.“…We assessed CNS activation, defined as blood oxygen level dependent (BOLD) signal, in response to food pictures in obese patients with type 2 diabetes (n = 20) and healthy lean individuals (n = 20) using functional magnetic resonance imaging (fMRI). fMRI was performed in the fasted state and after meal intake on two occasions, once during infusion of the GLP-1 receptor antagonist exendin 9-39, which was administered to block actions of endogenous GLP-1, and on the other occasion during saline (placebo) infusion. …”
Publicado 2015
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1310por Robinson, Emma, Tate, Mitchel, Lockhart, Samuel, McPeake, Claire, O’Neill, Karla M., Edgar, Kevin S., Calderwood, Danielle, Green, Brian D., McDermott, Barbara J., Grieve, David J.“…IL-1β, TNF-α, IL-10, Fizz1) in the presence of GLP-1(9–36)amide versus exendin-4. CONCLUSIONS: These data suggest that GLP-1(9–36)amide confers selective protection against post-MI remodelling via preferential preservation of diastolic function, most likely due to modulation of infiltrating macrophages, indicating that this often overlooked GLP-1 breakdown product may exert significant actions in this setting which should be considered in the context of GLP-1 therapy in patients with cardiovascular disease.…”
Publicado 2016
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1311por Yusta, Bernardo, Matthews, Dianne, Flock, Grace B., Ussher, John R., Lavoie, Brigitte, Mawe, Gary M., Drucker, Daniel J.“…RESULTS: Acute administration of the GLP-1R agonist exendin-4 lowered glucose but had no effect on GB volume in mice. …”
Publicado 2017
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1312por Lee, Clare, Lawler, Helen, Tan, Marilyn, Davis, Dawn, Tong, Jenny, Glodowski, Michele, Rogowitz, Elisa, Lamendola, Cindy, Karaman, Rowan, Dar, Moahad, Porter, Lisa, Craig, Colleen“…Avexitide (formerly exendin 9-39) is a first-in-class glucagon-like peptide-1 (GLP-1) receptor antagonist in development as a liquid formulation for subcutaneous (SC) injection for treatment of post-bariatric hypoglycemia (PBH). …”
Publicado 2019
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1313por Sforza, Annalisa, Vigorelli, Vera, Rurali, Erica, Perrucci, Gianluca Lorenzo, Gambini, Elisa, Arici, Martina, Metallo, Alessia, Rinaldi, Raffaella, Fiorina, Paolo, Barbuti, Andrea, Raucci, Angela, Sacco, Elena, Rocchetti, Marcella, Pompilio, Giulio, Genovese, Stefano, Vinci, Maria Cristina“…The selective GLP-1R antagonist exendin (9–39) abrogated LIRA-dependent ERK1/2 and AKT phosphorylation along with the related protective effects. …”
Publicado 2022
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1314por Chichura, Kylie, Elfers, Clinton, Salameh, Therese, Sweet, Ian, Roth, Christian, Doyle, Prof Robert“…Based on rational design and in silico modelling of the glucagon-like peptide 1-receptor agonist (GLP1RA) exendin-4 (Ex4) and the neuropeptide Y2 receptor (Y2R) agonist peptide YY (PYY) 3-36, we have developed and screeened several new monomeric chimeric peptides that display dual agonism of the anorectic Y2R and the glucoregulatory GLP1R. …”
Publicado 2022
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1315por Yeğit, Osman Ozan, Sarıbeyliler, Göktuğ, Karadağ, Pelin, Demir, Semra, Gül, Nurdan, Ünal, Derya, Gelincik Akkor, Aslı“…One report revealed that a patient with a level 1 anaphylaxis according to Brighton Criteria due to an exendin based GLP-1 receptor agonist was able to tolerate liraglutide (Human GLP-1 analogue), the alternative GLP-1 receptor agonist. …”
Publicado 2023
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1316por Muller, Dion R. P., Stenvers, Dirk J., Malekzadeh, Arjan, Holleman, Frederik, Painter, Rebecca C., Siegelaar, Sarah E.“…In animal studies, GLP1-agonists were associated with reduced fetal weight and/or growth, delayed ossification and skeletal variants, usually associated with a reduction in maternal weight gain and decreased food consumption. Exendin-4 (GLP1-agonist) was not transported across the maternal-fetal placental interface. …”
Publicado 2023
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1317por Obata, Atsushi, Kimura, Tomohiko, Obata, Yoshiyuki, Shimoda, Masashi, Kinoshita, Tomoe, Kohara, Kenji, Okauchi, Seizo, Hirukawa, Hidenori, Kamei, Shinji, Nakanishi, Shuhei, Mune, Tomoatsu, Kaku, Kohei, Kaneto, Hideaki“…During an IPGTT after pre-treatment with exendin-4 (Ex-4), glucose tolerance was significantly impaired in knockout mice. …”
Publicado 2019
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1318por Roth, Christian Ludwig, Milliken, Brandon T, Elfers, Clinton, Sweet, Ian, Doyle, Robert“…Based on rational design and in silico modelling of the glucagon-like peptide 1-receptor agonist (GLP1RA) exendin-4 (Ex4) and the neuropeptide Y2 receptor (Y2R) agonist peptide YY (PYY) (3-36), our group has developed and tested several new monomeric chimeric peptides that display dual agonism of the anorectic Y2R and the glucoregulatory GLP1R. …”
Publicado 2020
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1319“…To confirm the effect of GLP-1R and PI3K/Akt in CM, a GLP-1R selective agonist (liraglutide) and antagonist (exendin(9–39)) and a PI3K selective antagonist (LY294002) were administered. …”
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1320por Craig, Colleen, McLaughlin, Tracey, Perelman, Dalia, Shamloo, Termeh, Tan, Marilyn“…The mechanisms mediating PBH have long been debated, though a critical role for excessive postprandial secretion of glucagon-like peptide-1 (GLP-1) has been established. Avexitide (exendin 9-39) is a first-in-class GLP-1 receptor antagonist in development for treatment of PBH. …”
Publicado 2022
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