Crystal Structures of the Viral Protease Npro Imply Distinct Roles for the Catalytic Water in Catalysis

por Zögg, Thomas, Sponring, Michael, Schindler, Sabrina, Koll, Maria, Schneider, Rainer, Brandstetter, Hans, Auer, Bernhard
Publicado 2013

Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease

por Osellame, Laura D., Rahim, Ahad A., Hargreaves, Iain P., Gegg, Matthew E., Richard-Londt, Angela, Brandner, Sebastian, Waddington, Simon N., Schapira, Anthony H.V., Duchen, Michael R.
Publicado 2013

The Genetic Makeup of the Drosophila piRNA Pathway

por Handler, Dominik, Meixner, Katharina, Pizka, Manfred, Lauss, Kathrin, Schmied, Christopher, Gruber, Franz Sebastian, Brennecke, Julius
Publicado 2013

Kinetochores Coordinate Pericentromeric Cohesion and Early DNA Replication by Cdc7-Dbf4 Kinase Recruitment

por Natsume, Toyoaki, Müller, Carolin A., Katou, Yuki, Retkute, Renata, Gierliński, Marek, Araki, Hiroyuki, Blow, J. Julian, Shirahige, Katsuhiko, Nieduszynski, Conrad A., Tanaka, Tomoyuki U.
Publicado 2013

Structural Definition Is Important for the Propagation of the Yeast [PSI(+)] Prion

por Marchante, Ricardo, Rowe, Michelle, Zenthon, Jo, Howard, Mark J., Tuite, Mick F.
Publicado 2013

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

por Cheung, Eric C., Athineos, Dimitris, Lee, Pearl, Ridgway, Rachel A., Lambie, Wendy, Nixon, Colin, Strathdee, Douglas, Blyth, Karen, Sansom, Owen J., Vousden, Karen H.
Publicado 2013

Polycomb Associates Genome-wide with a Specific RNA Polymerase II Variant, and Regulates Metabolic Genes in ESCs

por Brookes, Emily, de Santiago, Inês, Hebenstreit, Daniel, Morris, Kelly J., Carroll, Tom, Xie, Sheila Q., Stock, Julie K., Heidemann, Martin, Eick, Dirk, Nozaki, Naohito, Kimura, Hiroshi, Ragoussis, Jiannis, Teichmann, Sarah A., Pombo, Ana
Publicado 2012

Improved Insulin Sensitivity despite Increased Visceral Adiposity in Mice Deficient for the Immune Cell Transcription Factor T-bet

por Stolarczyk, Emilie, Vong, Chi Teng, Perucha, Esperanza, Jackson, Ian, Cawthorne, Michael A., Wargent, Edward T., Powell, Nick, Canavan, James B., Lord, Graham M., Howard, Jane K.
Publicado 2013

Context-Dependent Decay of Motor Memories during Skill Acquisition

por Ingram, James N., Flanagan, J. Randall, Wolpert, Daniel M.
Publicado 2013

Anthocyanins Double the Shelf Life of Tomatoes by Delaying Overripening and Reducing Susceptibility to Gray Mold

por Zhang, Yang, Butelli, Eugenio, De Stefano, Rosalba, Schoonbeek, Henk-jan, Magusin, Andreas, Pagliarani, Chiara, Wellner, Nikolaus, Hill, Lionel, Orzaez, Diego, Granell, Antonio, Jones, Jonathan D.G., Martin, Cathie
Publicado 2013

14-3-3 Proteins Interact with a Hybrid Prenyl-Phosphorylation Motif to Inhibit G Proteins

por Riou, Philippe, Kjær, Svend, Garg, Ritu, Purkiss, Andrew, George, Roger, Cain, Robert J., Bineva, Ganka, Reymond, Nicolas, McColl, Brad, Thompson, Andrew J., O’Reilly, Nicola, McDonald, Neil Q., Parker, Peter J., Ridley, Anne J.
Publicado 2013

WIP Provides an Essential Link between Nck and N-WASP during Arp2/3-Dependent Actin Polymerization

por Donnelly, Sara K., Weisswange, Ina, Zettl, Markus, Way, Michael
Publicado 2013

Norm-Based Coding of Voice Identity in Human Auditory Cortex

por Latinus, Marianne, McAleer, Phil, Bestelmeyer, Patricia E.G., Belin, Pascal
Publicado 2013

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2

por Humphrey, Sean J., Yang, Guang, Yang, Pengyi, Fazakerley, Daniel J., Stöckli, Jacqueline, Yang, Jean Y., James, David E.
Publicado 2013

RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms

por Fritsch, Ralph, de Krijger, Inge, Fritsch, Kornelia, George, Roger, Reason, Beth, Kumar, Madhu S., Diefenbacher, Markus, Stamp, Gordon, Downward, Julian
Publicado 2013

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin

por Keusekotten, Kirstin, Elliott, Paul Ronald, Glockner, Laura, Fiil, Berthe Katrine, Damgaard, Rune Busk, Kulathu, Yogesh, Wauer, Tobias, Hospenthal, Manuela Kathrin, Gyrd-Hansen, Mads, Krappmann, Daniel, Hofmann, Kay, Komander, David
Publicado 2013

ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation

por Myant, Kevin B., Cammareri, Patrizia, McGhee, Ewan J., Ridgway, Rachel A., Huels, David J., Cordero, Julia B., Schwitalla, Sarah, Kalna, Gabriela, Ogg, Erinn-Lee, Athineos, Dimitris, Timpson, Paul, Vidal, Marcos, Murray, Graeme I., Greten, Florian R., Anderson, Kurt I., Sansom, Owen J.
Publicado 2013

Three-Dimensional RNA Structure of the Major HIV-1 Packaging Signal Region

por Stephenson, James D., Li, Haitao, Kenyon, Julia C., Symmons, Martyn, Klenerman, Dave, Lever, Andrew M.L.
Publicado 2013

Insights into Degron Recognition by APC/C Coactivators from the Structure of an Acm1-Cdh1 Complex

por He, Jun, Chao, William C.H., Zhang, Ziguo, Yang, Jing, Cronin, Nora, Barford, David
Publicado 2013

Structure of Rhomboid Protease in Complex with β-Lactam Inhibitors Defines the S2′ Cavity

por Vinothkumar, Kutti R., Pierrat, Olivier A., Large, Jonathan M., Freeman, Matthew
Publicado 2013