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2481
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2482por Daar, Shahina, Pathare, Anil, Nick, Hanspeter, Kriemler-Krahn, Ulrike, Hmissi, Abdel, Habr, Dany, Taher, Ali“…Mean baseline liver iron concentration and median serum ferritin levels were 28.6 ± 10.3 mg Fe/g dry weight and 6334 ng/mL respectively, indicating high iron burden despite prior chelation therapy. Baseline LPI levels (0.98 ± 0.82 μmol/L) decreased significantly to 0.12 ± 0.16 μmol/L, 2 h after first deferasirox dose (P=0.0006). …”
Publicado 2009
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2483por Cho, Young-Eun, Lomeda, Ria-Ann R., Ryu, Sang-Hoon, Lee, Jong-Hwa, Beattie, John H., Kwun, In-Sook“…Trace mineral studies involving metal ion chelators have been conducted in investigating the response of gene and protein expressions of certain cell lines but a few had really focused on how these metal ion chelators could affect the availability of important trace minerals such as Zn, Mn, Fe and Cu. …”
Publicado 2007
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2484“…Caffeic acid seems to chelate of iron ion at the catechol moiety. Indeed, the inhibitory effect by caffeic acid was greatly diminished in the presence of desferrioxamine, a potent iron chelator which removes iron ion in the Fe (III)-caffeic acid complex. …”
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2485por Ferrer, Patricia, Tripathi, Abhai K., Clark, Martha A., Hand, Carla Cerami, Rienhoff, Hugh Young, Sullivan, David J.“…Iron chelators for the treatment of malaria have proven therapeutic activity in vitro and in vivo in both humans and mice, but their clinical use is limited by the unsuitable absorption and pharmacokinetic properties of the few available iron chelators. …”
Publicado 2012
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2486por Knezović, Ana, Knapić, Marina, Osmanović-Barilar, Jelena, Mandel, Silvia, Youdim, Moussa, Riederer, Peter, Šalković-Petrišić, MelitaEnlace del recurso
Publicado 2012
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2487por Sruamsiri, Rosarin, Chaiyakunapruk, Nathorn, Pakakasama, Samart, Sirireung, Somtawin, Sripaiboonkij, Nintita, Bunworasate, Udomsak, Hongeng, Suradej“…This study aimed to estimate the cost-utility of RI-HSCT compared with blood transfusions combined with iron chelating therapy (BT-ICT) for adolescent and young adult with severe thalassemia in Thailand. …”
Publicado 2013
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2488“…Correlation between iron chelating and radical scavenging activities among the extracts implies the presence of dual-function phytoconstituents with concurrent iron chelating and radical scavenging activities. …”
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2489por Torres, Elizabeth B., Nguyen, Jillian, Mistry, Sejal, Whyatt, Caroline, Kalampratsidou, Vilelmini, Kolevzon, Alexander“…Background: There is a critical need for precision phenotyping across neurodevelopmental disorders, especially in individuals who receive a clinical diagnosis of autism spectrum disorder (ASD). Phelan-McDermid deletion syndrome (PMS) is one such example, as it has a high penetrance of ASD. …”
Publicado 2016
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2490“…Our data suggest that iron chelation could be considered as a supplementary treatment in the PCN-positive infections.…”
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2491por Pedraza-Chaverrí, José, Gil-Ortiz, Mariana, Albarrán, Gabriela, Barbachano-Esparza, Laura, Menjívar, Marta, Medina-Campos, Omar N“…In addition, it was found that the garlic extracts were unable to chelate Cu(2+). CONCLUSIONS: (a) the heating of aqueous extracts of raw garlic or garlic powder or the heating of garlic cloves by boiling, microwave or pickling do not affect garlic's ability to inhibit Cu(2+)-induced lipoprotein oxidation in human serum, and (b) this ability is not secondary to Cu(2+)-chelation.…”
Publicado 2004
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2492por Yassin, Mohamed, Soliman, Ashraf T, De Sanctis, Vincenzo, Moustafa, Abbas, Samaan, Sandra Abou, Nashwan, Abdulqadir“…This oral chelation proved to be effective in clearing her hepatic iron overload after six months (LIC: 2 mg/g dry tissue), without side effects. …”
Publicado 2017
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2493“…The observed deficits in synaptic plasticity were restored upon chelation of zinc using a cell‐permeable chelator. …”
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2494“…We show that BAPTA-AM, an intracellular Ca(2+) chelator, synergistically enhances dexamethasone lethality in two human ALL cell lines and in three primary specimens. …”
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2495“…The purpose of the work was to check whether the application of Fe-glycinate chelate in mixtures fed to poultry in an amount covering 50 or 25% of the requirement would decrease the physical, morphometric and strength parameters of tibia bones in male Ross-308 broiler chickens in comparison to groups receiving Fe in an amount covering 100% of the requirement in the form of glycinate chelate or sulphate. …”
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2496por Chofor, René, Risseeuw, Martijn D.P., Pouyez, Jenny, Johny, Chinchu, Wouters, Johan, Dowd, Cynthia S., Couch, Robin D., Van Calenbergh, Serge“…Fourteen new fosmidomycin analogues with altered metal chelating groups were prepared and evaluated for inhibition of E. coli Dxr, M. tuberculosis Dxr and the growth of P. falciparum K1 in human erythrocytes. …”
Publicado 2014
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2497
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2498por Singha, Monisha, Kumar, Gaurav, Jain, Diamond, Kumar N, Ganesh, Ray, Debashis, Ghosh, Anindya S., Basak, Amit“…[Image: see text] A method for rapid detection of metallo-β-lactamases NDM-5 and NDM-7 using conjugates of azidonaphthalimide and Zn(II) chelating motifs (like sulfonamides, hydroxamate, and terpyridine) is described. …”
Publicado 2019
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2499por Ramogida, Caterina F., Robertson, Andrew K. H., Jermilova, Una, Zhang, Chengcheng, Yang, Hua, Kunz, Peter, Lassen, Jens, Bratanovic, Ivica, Brown, Victoria, Southcott, Lily, Rodríguez-Rodríguez, Cristina, Radchenko, Valery, Bénard, François, Orvig, Chris, Schaffer, Paul“…BACKGROUND: Actinium-225 ((225)Ac, t(1/2) = 9.9 d) is a promising candidate radionuclide for use in targeted alpha therapy (TAT), though the currently limited global supply has hindered the development of a suitable Ac-chelating ligand and (225)Ac-radiopharmaceuticals towards the clinic. …”
Publicado 2019
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2500por Sobhani, Soheila, Rahmani, Farzaneh, Rahmani, Maryam, Askari, Marzieh, Kompani, Farzad“…AIM: To determine whether serum ferritin, liver transaminases, and regularity and type of iron chelation protocol can be used to predict liver iron load as assessed by T2* magnetic resonance imaging (MRI) in patients with beta thalassemia major (TM). …”
Publicado 2019
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