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  1. 361
    “…The results were confirmed more, by computational molecular modeling of the structure of proposed ligand-complexes by semi-imperical PM3 calculations, which determined negative heat of formation for the complexes Fe(III) and Cu(II) ions as -689.7 and -573.5, respectively and proposed chelating affinity of salvigenin in the following order: Fe(III) > Cu(II) >> Zn(II).…”
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    Phytochemical Analysis and Metal-chelation Activity of Achillea tenuifolia Lam.
  2. 362
    “…Thus hydroxyurea proves its role in reducing iron from iron overloaded mice. The iron chelating effect of these drugs can also be increased if given in combination.…”
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    Hydroxyurea Could Be a Good Clinically Relevant Iron Chelator
  3. 363
    “…The traditional role of iron chelation therapy has been to reduce body iron burden via chelation of excess metal from organs and fluids and its excretion via biliary-fecal and/or urinary routes. …”
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    Regional siderosis: a new challenge for iron chelation therapy
  4. 364
    por Mikhailov, Oleg V.
    Publicado 2014
    “…It has been noted that the assortment of macrocyclic metal chelates obtained as a result of using molecular nanotechnologies in such specific conditions considerably differs from the assortment of metal chelates formed at the conditions traditional for chemical synthesis.…”
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    Molecular nanotechnologies of gelatin-immobilization using macrocyclic metal chelates
  5. 365
    “…[Image: see text] Chelator-free nanoparticles for intrinsic radiolabeling are highly desirable for whole-body imaging and therapeutic applications. …”
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    Silica Nanoparticles as Substrates for Chelator-free Labeling of Oxophilic Radioisotopes
  6. 366
    “…Serum levels, however, remain unchanged from 1.7 ng/ml to 1.4 ng/ml. Although chelation therapy may have a role in the treatment of NSF, deferoxamine is too weak and a stronger chelator is needed.…”
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    Chelation of gadolinium with deferoxamine in a patient with nephrogenic systemic fibrosis
  7. 367
    “…Low ceruloplasmin (CP)-ferroxidase activity has been identified in the SN and the cerebrospinal fluid (CSF) of patients with PD. The iron chelator, deferiprone, reduces the abnormally high levels of iron in the SN. …”
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    Ceruloplasmin activity and iron chelation treatment of patients with Parkinson’s disease
  8. 368
    “…This and other evidence has led several groups to test dietary and chelation therapy-based regimens to manipulate brain metal concentrations in attempts to influence the progression of prion disease in experimental mice. …”
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    Antioxidant and Metal Chelation-Based Therapies in the Treatment of Prion Disease
  9. 369
    “…The use of combination therapies involving zinc and a chelator should be carefully monitored with close clinical observations and frequent biochemical tests, especially for WD patients with hepatic manifestations.…”
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    Combination Therapy Using Chelating Agent and Zinc for Wilson’s Disease
  10. 370
    “…The coordinating atoms in polydentate chelates are primarily heteroatoms. We present the first examples of pentadentate chelates with all binding atoms of the chelating agent being carbon atoms, denoted as CCCCC chelates. …”
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    CCCCC pentadentate chelates with planar Möbius aromaticity and unique properties
  11. 371
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    Effects of an oral iron chelator, deferasirox, on advanced hepatocellular carcinoma
  12. 372
    “…Iron chelation therapy is used to reduce iron overload development due to its deposition in various organs such as liver and heart after regular transfusion. …”
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    A Review on Iron Chelators in Treatment of Iron Overload Syndromes
  13. 373
    “…The compound-specific signature of VLX600 revealed a striking similarity to signatures generated by compounds known to chelate iron. Validation experiments including addition of ferrous and ferric iron in excess, EXAFS measurements, and structure activity relationship analyses showed that VLX600 chelates iron and supported the hypothesis that the biological effects of this compound is due to iron chelation. …”
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    Iron chelators target both proliferating and quiescent cancer cells
  14. 374
    “…PDA films exposed to CaCl(2) solutions during post-processing also enhance Fe(2+)/Fe(3+) chelation compared to pristine PDA films. These data illustrate that the molecular heterogeneity and non-equilibrium character of as-deposited PDA films afford control over the final composition by choosing post-processing conditions, but also demands forethought into how the performance of PDA-incorporated devices may change over time in salt solutions.…”
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    Calcium-Mediated Control of Polydopamine Film Oxidation and Iron Chelation
  15. 375
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    The Effect of Chelation Therapy on the Amino Aciduria and Peptiduria of Wilson's Disease
  16. 376
    por Drew, Simon C.
    Publicado 2017
    “…The “therapeutic chelation” approach to treating Alzheimer's disease (AD) evolved from the metals hypothesis, with the premise that small molecules can be designed to prevent transition metal-induced amyloid deposition and oxidative stress within the AD brain. …”
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    The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer's Disease
  17. 377
    “…Accurate and reliable methods of diagnosis and monitoring of body iron levels are essential, and the method of choice for measuring iron accumulation will depend on the patient’s needs and on the available facilities. Iron chelation therapy (ICT) remains the backbone of NTDT management and is one of the most effective and practical ways of decreasing morbidity and mortality. …”
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    Iron Overload and Chelation Therapy in Non-Transfusion Dependent Thalassemia
  18. 378
    “…In the process of reevaluation of glyphosate its chelating activity has hardly been discussed.…”
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    Glyphosate, a chelating agent—relevant for ecological risk assessment?
  19. 379
    “…Collectively, our studies demonstrate transition metal depletion, due to chelation, as the MoA of the 8-HNT series of compounds. …”
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    Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals
  20. 380
    “…The Click-to-Chelate approach is a highly efficient strategy for the radiolabeling of molecules of medicinal interest with technetium and rhenium-tricarbonyl cores. …”
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    Click-to-Chelate: Development of Technetium and Rhenium-Tricarbonyl Labeled Radiopharmaceuticals
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