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541“…The two coordinating ligands constrain the probe into a macrocyclic configuration through formation of an intramolecular chelate with a divalent transition metal ion. On hybridization with a DNA target, the intramolecular chelate in the snap-to-it probe dissociates, resulting in the probe ‘snapping-to’ and binding the target nucleic acid. …”
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542“…We report application of two-photon excitation of europium chelates to immunolabeling of epidermal growth factor receptor (EGFR) cell surface proteins on A431 cancer cells. …”
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543“…OBJECTIVES: Iron chelators, such as maltol and kojic acid, have antioxidant and anti-inflammatory properties. …”
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544por Choi, Jong Gwon, Kim, Jung-Lim, Park, Joohee, Lee, Soonwook, Park, Seh Jong, Kim, Jun Suk, Choi, Chul Won“…It has been reported that iron depletion by a chelator inhibits proliferation of some cancer cells. …”
Publicado 2012
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545por Kim, Jin Hee, Jang, Bong Geom, Choi, Bo Young, Kwon, Lyo Min, Sohn, Min, Song, Hong Ki, Suh, Sang Won“…Then, we injected the zinc chelator, clioquinol (CQ, 30 mg/kg), into the intraperitoneal space to reduce brain zinc availability. …”
Publicado 2012
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546por Pikula, Jiri, Hajkova, Pavlina, Bandouchova, Hana, Bednarova, Ivana, Adam, Vojtech, Beklova, Miroslava, Kral, Jiri, Ondracek, Karel, Osickova, Jitka, Pohanka, Miroslav, Sedlackova, Jana, Skochova, Hana, Sobotka, Jakub, Treml, Frantisek, Kizek, Rene“…This study reports on experience with accidental lead intoxication and responses to chelation therapy in captive Cinereous (Aegypius monachus) and Egyptian (Neophron percnopterus) Vultures. …”
Publicado 2013
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547por Prachayasittikul, Veda, Prachayasittikul, Supaluk, Ruchirawat, Somsak, Prachayasittikul, Virapong“…Metal imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. 8-Hydroxyquinoline (8HQ) is a small planar molecule with a lipophilic effect and a metal chelating ability. As a result, 8HQ and its derivatives hold medicinal properties such as antineurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory, and antidiabetic activities. …”
Publicado 2013
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548por Jang, Jun Ho, Lee, Je-Hwan, Yoon, Sung-Soo, Jo, Deog-Yeon, Kim, Hyeoung-Joon, Chung, Jooseop, Lee, Jong Wook“…Many Korean patients with transfusion-induced iron overload experience serious clinical sequelae, including organ damage, and require lifelong chelation therapy. However, due to a lack of compliance and/or unavailability of an appropriate chelator, most patients have not been treated effectively. …”
Publicado 2013
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550por Morita, Akinori, Ariyasu, Shinya, Ohya, Soichiro, Takahashi, Ippei, Wang, Bing, Tanaka, Kaoru, Uchida, Takatoshi, Okazaki, Haruna, Hanaya, Kengo, Enomoto, Atsushi, Nenoi, Mitsuru, Ikekita, Masahiko, Aoki, Shin, Hosoi, Yoshio“…The findings indicate that two of five zinc (II) chelators also suppressed apoptosis. Among the inhibitors tested, Bispicen (N,N'-Bis(2-pyridylmethyl)-1,2-ethanediamine) had the highest inhibition activity. …”
Publicado 2013
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551por Elli, Elena Maria, Belotti, Angelo, Aroldi, Andrea, Parma, Matteo, Pioltelli, Pietro, Pogliani, Enrico Maria“…Deferasirox (DSX) is the principal option currently available for iron-chelation-therapy (ICT), principally in the management of myelodysplastic syndromes (MDS), while in primary myelofibrosis (PMF) the expertise is limited. …”
Publicado 2014
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552por Ghaffari, Behnaz, Preshlock, Sean M., Plattner, Donald L., Staples, Richard J., Maligres, Peter E., Krska, Shane W., Maleczka, Robert E., Smith, Milton R.Enlace del recurso
Publicado 2014
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553“…[Image: see text] A spectroscopic investigation of the complexes formed between the Pb(II) ion and d-penicillamine (H(2)Pen), a chelating agent used in the treatment of lead poisoning, was carried out on two sets of alkaline aqueous solutions with C(Pb(II)) ≈ 10 and 100 mM, varying the H(2)Pen/Pb(II) molar ratio (2.0, 3.0, 4.0, 10.0). …”
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554por Żak, Patrycja, Rogalski, Szymon, Majchrzak, Mariusz, Kubicki, Maciej, Pietraszuk, Cezary“…New phenoxybenzylidene ruthenium chelates were synthesised from the second generation Grubbs catalysts bearing a triphenylphosphine ligand (or its para-substituted analogues) by metathesis exchange with substituted 2-vinylphenols. …”
Publicado 2015
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555por Wang, A. Ting, Lim, Teresa, Jamison, Jesslyn, Bush, Lauren, Soorya, Latha V., Tavassoli, Teresa, Siper, Paige M., Buxbaum, Joseph D., Kolevzon, Alexander“…BACKGROUND: Phelan-McDermid syndrome (PMS), a neurodevelopmental disorder caused by deletion or mutation in the SHANK3 gene, is one of the more common single-locus causes of autism spectrum disorder (ASD). …”
Publicado 2016
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557por Poschenrieder, Andreas, Schottelius, Margret, Schwaiger, Markus, Kessler, Horst, Wester, Hans-Jürgen“…RESULTS: Metalated pentixafor derivatives with cyclic and acyclic chelators were synthesized by solid-phase peptide synthesis and evaluated in vitro. …”
Publicado 2016
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558por Yamamoto, Naoki, Yamasaki, Takahiro, Takami, Taro, Uchida, Koichi, Fujisawa, Koichi, Matsumoto, Toshihiko, Saeki, Issei, Terai, Shuji, Sakaida, Isao“…We have reported that the iron chelator, deferoxamine can prevent liver fibrosis and preneoplastic lesions. …”
Publicado 2016
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559por Wu, Hao, Yang, Yan, Jiang, Sheng-Juan, Chen, Ling-Ling, Gao, Hai-Xia, Fu, Qing-Shan, Li, Feng, Ma, Bin-Guang, Zhang, Hong-Yu“…Copper and iron play important roles in a variety of biological processes, especially when being chelated with proteins. The proteins involved in the metal binding, transporting and metabolism have aroused much interest. …”
Publicado 2005
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560por Kim, Yoon-Myung, Choi, In-Hee, Kim, Jun Suk, Kim, Ja Hye, Cho, Ja Hyang, Lee, Beom Hee, Kim, Gu-Hwan, Choi, Jin-Ho, Seo, Eul-Ju, Yoo, Han-Wook“…Phelan-McDermid syndrome is a rare genetic disorder caused by the terminal or interstitial deletion of the chromosome 22q13.3. …”
Publicado 2016
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