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561por Alta, Roxana Y. P., Vitorino, Hector A., Goswami, Dibakar, Liria, Cleber W., Wisnovsky, Simon P., Kelley, Shana O., Machini, M. Terêsa, Espósito, Breno P.Enlace del recurso
Publicado 2017
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562por Shah, Nirmish R.“…The recommended treatment for removing excess iron in these patients is iron chelation therapy. Currently available iron chelators include deferoxamine, which is administered by injection, and deferasirox and deferiprone, both of which are administered orally. …”
Publicado 2017
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563“…Polyacrylonitrile (PAN) nanofibers were prepared by electrospinning and they were modified with hydroxylamine to synthesize amidoxime polyacrylonitrile (AOPAN) chelating nanofibers, which were applied to adsorb copper and iron ions. …”
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566“…The chelators were administered orally as either single or combined therapies for a period of 14 days. …”
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567por Dai, Lixiong, Jones, Chloe M., Chan, Wesley Ting Kwok, Pham, Tiffany A., Ling, Xiaoxi, Gale, Eric M., Rotile, Nicholas J., Tai, William Chi-Shing, Anderson, Carolyn J., Caravan, Peter, Law, Ga-Lai“…Despite established clinical utilisation, there is an increasing need for safer, more inert gadolinium-based contrast agents, and for chelators that react rapidly with radiometals. Here we report the syntheses of a series of chiral DOTA chelators and their corresponding metal complexes and reveal properties that transcend the parent DOTA compound. …”
Publicado 2018
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568por Cordina, Nicole M., Sayyadi, Nima, Parker, Lindsay M., Everest-Dass, Arun, Brown, Louise J., Packer, Nicolle H.“…The second method uses europium-chelating tags with long fluorescence lifetimes. These europium-chelating tags enhance background-free imaging due to the short fluorescent lifetimes of cellular autofluorescence. …”
Publicado 2018
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569por Charbon, Godefroid, Klitgaard, Rasmus N., Liboriussen, Charlotte Dahlmann, Thulstrup, Peter Waaben, Maffioli, Sonia Ilaria, Donadio, Stefano, Løbner-Olesen, Anders“…We show that DFO does not affect chromosomal replication initiation and suggest that it was identified due to its ability to chelate cellular iron. This limits the formation of reactive oxygen species, reduce oxidative DNA damage and promote processivity of DNA replication. …”
Publicado 2018
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570por Moreau, Caroline, Danel, Véronique, Devedjian, Jean Christophe, Grolez, Guillaume, Timmerman, Kelly, Laloux, Charlotte, Petrault, Maud, Gouel, Flore, Jonneaux, Aurélie, Dutheil, Mary, Lachaud, Cédrick, Lopes, Renaud, Kuchcinski, Grégory, Auger, Florent, Kyheng, Maeva, Duhamel, Alain, Pérez, Thierry, Pradat, Pierre François, Blasco, Hélène, Veyrat-Durebex, Charlotte, Corcia, Philippe, Oeckl, Patrick, Otto, Markus, Dupuis, Luc, Garçon, Guillaume, Defebvre, Luc, Cabantchik, Z. Ioav, Duce, James, Bordet, Régis, Devos, David“…However, classical iron chelation would induce systemic iron depletion. We assess the safety and efficacy of conservative iron chelation (i.e., chelation with low risk of iron depletion) in a murine preclinical model and pilot clinical trial. …”
Publicado 2018
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573por Shulha, T. N., Serdechnova, M., Lamaka, S. V., Wieland, D. C. F., Lapko, K. N., Zheludkevich, M. L.“…The application of the chelating agents help overcoming the typical technological limitations of direct LDH synthesis on Mg alloys. …”
Publicado 2018
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574“…Our institution has subsequently employed this strategy to reduce chelation interactions with HIV integrase inhibitors. …”
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575“…Two basic and simple synthetic routes for mono- and bis-maleimide bearing 1,4,7-triazacyclononane-N,N’,N’’-triacetic acid (NOTA) chelators as new bifunctional chelators are described. …”
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576“…Herein we survey existing site-specific chelator-protein conjugation methods. These include chelator attachment to cysteines/disulfide bonds or the glycan region of the antibody, enzyme-mediated chelator conjugation, and incorporation of sequences of amino acids that chelate the radiometal. …”
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577por Bautista Villarreal, Minerva, Gallardo Rivera, Claudia T., García Márquez, Eristeo, Rodríguez Rodríguez, José, Núñez González, María Adriana, Chávez Montes, Abelardo, Báez González, Juan G.“…The second method applied was the use of anionic chelating biopolymers, such as arabic gum solution (AG) and mesquite gum solution (MG), and the third method was extraction with a solvent (S(A)). …”
Publicado 2018
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578“…We present a patient with Phelan‐McDermid syndrome, a rare neurodevelopmental disorder caused by a 22q13 deletion, with the previously undescribed finding of progressive dilation of the great arteries. …”
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579“…Furthermore, the distribution and allocation of Fe within the plant could be modified when plants were supplied with water soluble Fe-HS complexes as compared with other natural or synthetic chelates. These effects are in line with previous observations showing that treatments with HS were able to induce changes in root morphology and modulate plant membrane activities related to nutrient acquisition, pathways of primary and secondary metabolism, hormonal and reactive oxygen balance. …”
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580por Islam, Sufia, Chisti, Mohammod Jobayer, Ahmed, Muniruddin, Anwar, Nafiza, Lehmann, Christian“…This review will look into the use of iron chelators in order to reduce microbial growth and attenuate a dysregulated immune response during infection. …”
Publicado 2019
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