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741“…Successful in vivo chelation treatment of metal intoxication requires that a significant fraction of the administered chelator in fact chelate the toxic metal. …”
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742“…To understand this better, we tested the strength of the association in children with elevated blood lead concentrations and whether succimer chelation changed blood pressure as it did blood lead. …”
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743por Chisolm, J J“…In the overall long-term management of lead poisoning, chelation therapy can have short-term benefits; however, these benefits must be accompanied by drastic reduction in environmental exposure to lead if therapy is to have any long-term benefit. …”
Publicado 1990
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744“…At physiologically relevant concentrations, extracellular DNA has antimicrobial activity, causing cell lysis by chelating cations that stabilize lipopolysaccharide (LPS) and the outer membrane (OM). …”
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745“…BACKGROUND: Metal chelators have gained much attention as potential anti-cancer agents. …”
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746por Won, Sung Chul, Han, Dong Kyun, Seo, Jong Jin, Chung, Nak Gyun, Park, Sang Kyu, Park, Kyung Bae, Kook, Hoon, Lyu, Chuhl JooEnlace del recurso
Publicado 2010
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747
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748por Kanakaraj, Indhu, Jewell, David L., Murphy, Jason C., Fox, George E., Willson, Richard C.“…Here we describe an efficient method of purifying PCR products by specifically removing error products, excess primers, and unincorporated dNTPs from PCR product mixtures using flow-through metal-chelate affinity adsorption. By flowing a PCR product mixture through a Cu(2+)-iminodiacetic acid (IDA) agarose spin column, 94–99% of the dNTPs and nearly all the primers can be removed. …”
Publicado 2011
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749por Kwiatkowski, Janet L“…These chelators differ in their modes of administration, pharmacokinetics, efficacy with regard to organ-specific iron removal, and adverse-effect profiles. …”
Publicado 2011
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750por Ghugre, Nilesh R, Barry, Jennifer, Wood, John C, Moody, Alan, Strauss, Bradley H, Wright, GrahamEnlace del recurso
Publicado 2012
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751por Johansson, Ann-Sofi, Vestling, Monika, Zetterström, Per, Lang, Lisa, Leinartaitė, Lina, Karlström, Mikael, Danielsson, Jens, Marklund, Stefan L., Oliveberg, Mikael“…Moreover, we demonstrate that the toxic action of apoSOD1 relies on the protein's ability to chelate Zn(2+) ions from the growth medium. The decreased cell viability that accompanies this extraction is presumably based on disturbed Zn(2+) homeostasis. …”
Publicado 2012
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752Targeted cellular ionic calcium chelation by oxalates: Implications for the treatment of tumor cells“…The third is via calcium chelation, which causes cell apoptosis by converting ionic calcium into a calcium salt. …”
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753por Miller, Gloria, Begonia, Gregorio, Begonia, Maria, Ntoni, Jennifer, Hundley, Oscar“…Further increases in root Pb concentrations were attributed to chelate amendments. In the absence of chelates, translocation of Pb from roots to shoots was minimal. …”
Publicado 2008
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754
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755por Makis, Alexandros, Chaliasos, Nikolaos, Alfantaki, Sapfo, Karagouni, Paraskevi, Siamopoulou, Antigone“…Iron overload in hemoglobinopathies is secondary to blood transfusions, chronic hemolysis, and increased iron absorption and leads to tissue injury requiring the early use of chelating agents. The available agents are parenteral deferoxamine and oral deferiprone and deferasirox. …”
Publicado 2013
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756por Mosayebnia, Mona, Shafiee-Ardestani, Mehdi, Pasalar, Parvin, Mashayekhi, Mojgan, Amanlou, Massoud“…MATERIALS AND METHODS: Diethylenetriaminepentaacetic acid-D-deoxy-glucosamine (DTPA-DG) was synthesized and examined for its activity as a cell-permeable iron chelator in human hepatocellular carcinoma (HEPG2) cell line exposed to high concentration of iron sulfate and compared with deferoxamine (DFO), a prototype iron chelator. …”
Publicado 2014
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757por Moreno-Navarrete, José María, Ortega, Francisco, Moreno, Maria, Serrano, Marta, Ricart, Wifredo, Fernández-Real, José Manuel“…In addition, the effects of exogenous LTF administration and iron chelation [using deferoxamine (DFO, 10 μM)] were tested. …”
Publicado 2014
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758por Zhao, J., Allee, G., Gerlemann, G., Ma, L., Gracia, M. I., Parker, D., Vazquez-Anon, M., Harrell, R. J.“…Three studies were conducted to investigate whether a chelated Cu can replace CuSO(4) as a growth promoter in pigs. …”
Publicado 2014
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759‘Unconventional’ Coordination Chemistry by Metal Chelating Fragments in a Metalloprotein Active Sitepor Martin, David P., Blachly, Patrick G., Marts, Amy R., Woodruff, Tessa M., de Oliveira, César A. F., McCammon, J. Andrew, Tierney, David L., Cohen, Seth M.“…[Image: see text] The binding of three closely related chelators: 5-hydroxy-2-methyl-4H-pyran-4-thione (allothiomaltol, ATM), 3-hydroxy-2-methyl-4H-pyran-4-thione (thiomaltol, TM), and 3-hydroxy-4H-pyran-4-thione (thiopyromeconic acid, TPMA) to the active site of human carbonic anhydrase II (hCAII) has been investigated. …”
Publicado 2014
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760“…There are currently three approved commercially available iron chelators: deferoxamine, deferiprone and deferasirox. …”
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