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821“…Purpose: In this study, we independently synthesised and labelled a novel bidentate bifunctional chelating agent, (177)Lu-3,4-HOPO-Cetuximab, that achieved tight binding between targeting and radioactivity, and evaluated its targeted killing ability of cells in vitro and in vivo. …”
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822por Dyar, Brianna, Meaddough, Erika, Sarasua, Sara M., Rogers, Curtis, Phelan, Katy, Boccuto, Luigi“…Phelan-McDermid syndrome (PMS) is a genetic disorder often characterized by autism or autistic-like behavior. …”
Publicado 2021
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823por Martins, Ana S., Batista de Carvalho, Ana L. M., Marques, Maria P. M., Gil, Ana M.“…This paper reports the first metabolomics study of the impact of new chelates Pt(2)Spm and Pd(2)Spm (Spm = Spermine) on human osteosarcoma cellular metabolism, compared to the conventional platinum drugs cisplatin and oxaliplatin, in order to investigate the effects of different metal centers and ligands. …”
Publicado 2021
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824por Busemann, Anja, Flaspohler, Ingrid, Zhou, Xue-Quan, Schmidt, Claudia, Goetzfried, Sina K., van Rixel, Vincent H. S., Ott, Ingo, Siegler, Maxime A., Bonnet, SylvestreEnlace del recurso
Publicado 2021
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825por Fastman, J., Foss-Feig, J., Frank, Y., Halpern, D., Harony-Nicolas, H., Layton, C., Sandin, S., Siper, P., Tang, L., Trelles, P., Zweifach, J., Buxbaum, J. D., Kolevzon, A.“…BACKGROUND: Phelan-McDermid syndrome (PMS) is a rare neurodevelopmental disorder caused by haploinsufficiency of the SHANK3 gene and characterized by global developmental delays, deficits in speech and motor function, and autism spectrum disorder (ASD). …”
Publicado 2021
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826por Peña, Quim, Sciortino, Giuseppe, Maréchal, Jean-Didier, Bertaina, Sylvain, Simaan, A. Jalila, Lorenzo, Julia, Capdevila, Mercè, Bayón, Pau, Iranzo, Olga, Palacios, Òscar“…[Image: see text] Three novel dinuclear Cu(II) complexes based on a N,N,O-chelating salphen-like ligand scaffold and bearing varying aromatic substituents (−H, −Cl, and −Br) have been synthesized and characterized. …”
Publicado 2021
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827“…This paper presents an exploratory eco-park design project in Helwan, Egypt. The project focuses on the opportunity of integrating marginalised natural environments, such as Wadis (dry streams), with the urban fabric through Eco-landscape design. …”
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828“…A chelation-assisted oxidative addition of gold(i) into the C–C bond of biphenylene is reported here. …”
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829“…Iron chelation therapy (ICT) is an important tool in the treatment of transfusion-dependent lower-risk myelodysplastic syndrome (MDS) patients. …”
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830por Jin, Xueyang, Zhang, Ming, Lu, Jinghui, Duan, Ximeng, Chen, Jinyao, Liu, Yue, Chang, Wenqiang, Lou, Hongxiang“…Hinokitiol exhibits potent antifungal activity and iron-chelating ability. However, their relationships have not been established. …”
Publicado 2021
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831por Toader, Gabriela, Pulpea, Daniela, Rotariu, Traian, Diacon, Aurel, Rusen, Edina, Moldovan, Andreea, Podaru, Alice, Ginghină, Raluca, Alexe, Florentina, Iorga, Ovidiu, Bajenaru, Sorina Aurora, Ungureanu, Mihai, Dîrloman, Florin, Pulpea, Bogdan, Leonat, Lucia“…In this study, novel strippable coatings for heavy metal and radionuclides decontamination were developed based on the film-forming ability of polyvinyl alcohol, with the remarkable metal retention capacity of bentonite nanoclay, together with the chelating ability of sodium alginate and with “new-generation” “green” complexing agents: iminodisuccinic acid (IDS) and 2-phosphonobutane-1,2,4-tricarboxylic acid (PBTC). …”
Publicado 2021
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832por Poonkuzhi Naseef, Punnoth, Elayadeth-Meethal, Muhammed, Mohammed Salim, K.T., Anjana, A, Muhas, C, Abdul Vajid, K., Saheer Kuruniyan, Mohamed“…It can be combined with monoclonal antibodies, antioxidants, corticosteroids, and lactoferrin to make iron chelation therapy effective for COVID-19 victims. In this article, we analyze the antiviral and antifibrotic activity of iron chelators, thereby promoting iron depletion therapy as a potentially innovative treatment strategy for COVID-19.…”
Publicado 2022
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834Metal Complexes or Chelators with ROS Regulation Capacity: Promising Candidates for Cancer Treatment“…Effective intervention in the ROS homeostasis of cancer cells by chelating agents or metal complexes has already developed into an important anti-cancer strategy. …”
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835por Gerzilov, Vasko, Alexandrova, Albena, Andreeva, Madlena, Tsvetanova, Elina, Georgieva, Almira, Petrov, Petar, Stefanov, RossenEnlace del recurso
Publicado 2022
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836por Cammarata-Scalisi, Francisco, Callea, Michele, Martinelli, Diego, Willoughby, Colin Eric, Tadich, Antonio Cárdenas, Araya Castillo, Maykol, Lacruz-Rengel, María Angelina, Medina, Marco, Grimaldi, Piercesare, Bertini, Enrico, Nevado, Julián“…Phelan–McDermid syndrome (PMS) is a rare, heterogeneous, and complex neurodevelopmental disorder. …”
Publicado 2022
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837
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838por Choudhary, Neha, Barrett, Kendall E., Kubeil, Manja, Radchenko, Valery, Engle, Jonathan W., Stephan, Holger, de Guadalupe Jaraquemada-Peláez, María, Orvig, Chris“…The bisoxine hexadentate chelating ligand, H(3)glyox was investigated for its affinity for Mn(2+), Cu(2+) and Lu(3+) ions; all three metal ions are relevant with applications in nuclear medicine and medicinal inorganic chemistry. …”
Publicado 2021
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839“…We performed Density Functional Theory calculations comparing the binding energies of aluminum–chelator complexes and the binding energy of the aluminum–human serum transferrin complex and determined the charge transfer of the aluminum–chelator complex. …”
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840por Dais, Tyson N., Nixon, David J., Brothers, Penelope J., Henderson, William, Plieger, Paul G.“…A comparative study between three experimentally known beryllium chelators (EDTA, NTP, and 10-HBQS) and two tetradentate tripodal di-pyridine-based receptors (HL and HL-NH(2)), specifically designed to bind Be(2+) cations, has been undertaken in the aqueous phase at the B3LYP/6-311++G(d,p) computational level. …”
Publicado 2020
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