“…[Image: see text] With the objective of studying the conformational and macrocyclic effects of selected metal chelates on their peroxidase activities, Cu(2+) and Fe(3+) complexes were synthesized with a macrocyclic derivative of ethylenediaminetetraacetic acid and o-phenylenediamine (abbreviated as edtaodH(2)) and its new open-chain analogue (edtabzH(2)). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Likewise, the antioxidant activities (DPPH, chelating ability and reducing power) of CG-MRPs were investigated. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The upregulation of iron uptake was not related to any putative ability of LA to chelate Fe(2+), but was somewhat linked to stress response. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Treatment options include life-long copper chelation therapy and/or decrease in copper intake. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The shaping and cleaning involved the use of chelating gel MM EDTA 19% and continuous irrigation with sodium hypochlorite 2.5%. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Moreover, the calcium channel inhibitor LaCl(3) and the intracellular calcium chelator acetoxymethyl-1, 2-bis (2-aminophenoxy) ethic acid (BAPTA-AM) inhibited this calcium increase and prevented ceramide-induced PCD. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The iron chelator deferoxamine has been shown to inhibit ferroptosis in spinal cord injury. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It has previously been demonstrated that fluoroquinolone antibiotics such as ciprofloxacin can chelate metal ions. To investigate how ciprofloxacin resistance is affected by the presence of metals, we quantified selection dynamics between a ciprofloxacin-susceptible and a ciprofloxacin-resistant Escherichia coli strain across a gradient of ciprofloxacin concentrations in presence and absence of zinc. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We also found that RGCs were rescued from some glaucoma relevant stress factors by incubation with the iron chelator deferiprone (DFP). Thus, the mito-QC reporter-based model is a valuable tool for accurately analyzing mitophagy in the context of glaucoma.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Incorporation of fatty acids, especially the long chain polyunsaturated fatty acids (PUFA), into EGCG resulted in increased peroxyl radical scavenging activity, as measured by ORAC (oxygen radical absorbance capacity) assay, and metal chelation capacity. However, the esters exhibited decreased reducing power. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this work, a recombinant CHIKV nsP2pro and a C-terminally truncated variant were expressed in Escherichia coli and purified by metal–chelate chromatography. The enzymatic properties of the proteinase were then determined using specific synthetic fluorogenic substrates. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the 2′,7′-dichlorodihydrofluorescein diacetate assay, we found out GONR could chelate metal ions to scavenge reactive oxygen species. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Depleting intracellular iron stores, either with the use of iron chelating agents or mimicking endogenous regulation mechanisms, such as microRNAs, present attractive therapeutic opportunities, some of which are currently under clinical investigation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this review, we identify the main limitations of current treatments and discuss different alternatives that have been put forward in recent years, with an emphasis on less conventional therapeutics, such as antimicrobial peptides, bacteriophages, iron chelators, or host-directed therapies. We also review new forms of the use of old drugs, including the repurposing of non-antibacterial molecules and the incorporation of antimicrobials into ionic liquids. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here we examined mitophagy that is induced upon iron chelation and found that the transcriptional activity of HIF1α, in part through upregulation of BNIP3 and NIX, is an essential mediator of this pathway in SH-SY5Y cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The tridentate L6, which contains tri-pyridine chelate with benzene connectors, showed the highest binding energies for Pu(IV) and PuO(2)(VI) in water. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Site directed incorporation of Cu(2+)-chelated to a ligand, 2,2′dipicolylamine (DPA) is potentially an attractive strategy for site-specific, nucleotide independent Cu(2+)-labelling in DNA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Both ferric and nonferric lin-Ent localize to all three pockets of the Scn calyx, consistent with Scn capture of lin-Ent both before and after Fe(III) chelation. These findings raise the possibility that Scn neutralizes both siderophores and siderophore-bound iron during infections. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The increased serum survival and iron chelating genes iss and iroN were highly prevalent in genomes from both acute and chronic salpingitis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Food and Drug Administration (FDA) -approved calcium chelator, hexametaphosphate (HMP), is explored as a novel treatment paradigm for this condition, which targets the chemical, rather that biological, ​bone formation pathways. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso