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  1. 10141
    “…Colorimetric methods were used to assess antioxidant activity, free radical scavenging capacity, protein-bound carbonyl groups, thiol groups and metal chelation activities in addition to phenolic, total flavonoid and flavonol content of aged and fresh garlic extracts. …”
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    Aged garlic has more potent antiglycation and antioxidant properties compared to fresh garlic extract in vitro
  2. 10142
    “…Plant constituents could act as chelating/reducing or capping agents for synthesis of silver nanoparticles (AgNPs). …”
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    Biosynthesis of Silver Nanoparticles Using Taxus yunnanensis Callus and Their Antibacterial Activity and Cytotoxicity in Human Cancer Cells
  3. 10143
    “…Previously, we found amphotericin B (AMB) and the iron chelator, lactoferrin (LF), were synergistic against a range of different fungal pathogens. …”
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    Transcriptome and network analyses in Saccharomyces cerevisiae reveal that amphotericin B and lactoferrin synergy disrupt metal homeostasis and stress response
  4. 10144
    “…Total phenolic content was tested by Folin–Ciocalteau reagent based assay whilst DPPH free radical scavenging assay, metal chelating assay, hydrogen peroxide scavenging assay, reducing power assay and β carotene-linoleic assay were used to assess the antioxidant potential of A. vera methanolic leaf extracts. …”
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    Effect of climate change on phytochemical diversity, total phenolic content and in vitro antioxidant activity of Aloe vera (L.) Burm.f.
  5. 10145
    “…The increase in [Ca(2+)](i) in response to Ami, Fur, Lox, and Min was reduced significantly (P < 0.01) when the external calcium was reduced to nM concentration by chelation with EGTA. The data suggest that many ion channel regulators mobilize [Ca(2+)](i). …”
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    Intracellular Calcium Mobilization in Response to Ion Channel Regulators via a Calcium-Induced Calcium Release Mechanism
  6. 10146
    “…BACKGROUND: Excessive iron accumulation in the visceral organs creates problems for patients with beta-thalassemia major. Despite chelation therapy, mortality rate from the complications of this disease is still quite high. …”
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    The Effects of Nutrition, Exercise, and a Praying Program on Reducing Iron Overload in Patients With Beta-Thalassemia Major: A Randomized Clinical Trial
  7. 10147
    “…KEY FINDINGS: The PARP‐1 inhibitor olaparib, the topoisomerase I inhibitor topotecan, the proteasome inhibitor bortezomib, the inhibitor of the P53–MDM2 interaction nutlin‐3 and the copper‐chelated form of the oxidising agent disulfiram (DSF:Cu) all significantly enhanced the inhibition of the growth of spheroids induced by (131)I‐MIP‐1095. …”
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    Preliminary evaluation of prostate‐targeted radiotherapy using (131)I‐MIP‐1095 in combination with radiosensitising chemotherapeutic drugs
  8. 10148
    “…Moreover, the Gd-Au NCs exhibit a high longitudinal relaxivity value (r1) of 22.111 s(−1) per mM of Gd in phosphate-buffered saline (PBS), which is six times higher than that of commercial Magnevist (A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid, Gd-DTPA, r1 = 3.56 mM(−1)·s(−1)). …”
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    Facile Synthesis of Gd-Functionalized Gold Nanoclusters as Potential MRI/CT Contrast Agents
  9. 10149
    “…Interestingly, the magnitude of LTP was not modified in aged rats even by perfusion with ACSF containing 100 nM ZnCl(2), but enhanced by perfusion with ACSF containing 10 mM CaEDTA, an extracellular Zn(2+) chelator. The present study indicates that the basal levels of extracellular Zn(2+), which are in the range of low nanomolar concentrations, are critical for synaptic activity and perhaps increased age-dependently.…”
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    In vitro and in vivo physiology of low nanomolar concentrations of Zn(2+) in artificial cerebrospinal fluid
  10. 10150
    “…The arthralgia was resolved with copper chelation therapy. CONCLUSIONS: Wilson’s disease with osseomuscular type occurs without typical hepatic or neurological symptoms, which makes the clinical diagnosis challenging. …”
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    Clinical features and outcome in patients with osseomuscular type of Wilson’s disease
  11. 10151
    “…This integrative systems approach has strong predictive power, indicating (as has indeed been shown) that both natural and pharmaceutical iron chelators might have useful protective roles in arresting cognitive decline, and that a further assessment of the role of microbes in AD development is more than highly warranted.…”
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    A Bacterial Component to Alzheimer’s-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease
  12. 10152
    “…Others are reducing power, metal chelating and lipid peroxidation inhibition activities. …”
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    BioActivities of Coturnix japonica (quail) egg yolk and albumen against physiological stress
  13. 10153
    “…DOTA-PEI was prepared and contained an average of 16 chelates per PEI; the compound was radio-labeled with (149)Promethium and conjugated to Trastuzumab. …”
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    Synthesis and Preliminary Biological Evaluations of Fluorescent or (149)Promethium Labeled Trastuzumab-Polyethylenimine
  14. 10154
    “…In addition, the ACDB-mediated cellular apoptosis was suppressed by transfecting cells with glucose-regulated protein (GRP) and calpain siRNA or treating cells with ER stress chelators and caspase inhibitors. Interestingly, animal experiments illustrated a reduction in the tumor volume following ACDB treatment. …”
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    A novel benzofuran derivative, ACDB, induces apoptosis of human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress
  15. 10155
    por Gokarn, Karuna, Pal, Ramprasad B.
    Publicado 2017
    “…In this preliminary in vitro study, the anti-tuberculosis (anti-TB) activity of exogenous iron chelators (xenosiderophores) such as Exochelin-MS (Exo-MS) and Deferoxamine-B (DFO-B) was evaluated against ten multi-drug-resistant (MDR) and seven pyrazinamide-resistant (PZA (R)) Mtb isolates. …”
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    Preliminary evaluation of anti-tuberculosis potential of siderophores against drug-resistant Mycobacterium tuberculosis by mycobacteria growth indicator tube-drug sensitivity test
  16. 10156
    “…The pharmacological characterization and molecular docking studies for the structure-activity rationalization, allowed the identification of 3β-azido-6α-ethyl-7α-hydroxy-5β-cholan-24-oic acid (compound 2), a potent and selective FXR agonist with a nanomolar potency in transactivation assay and high efficacy in the recruitment of SRC-1 co-activator peptide in Alfa Screen assay. …”
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    Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases
  17. 10157
    “…Of the four phenazines 1-HP had a redox-independent function; being able to chelate metal ions 1-HP induced A. fumigatus iron starvation. …”
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    Pseudomonas aeruginosa manipulates redox and iron homeostasis of its microbiota partner Aspergillus fumigatus via phenazines
  18. 10158
    “…Further, intracellular calcium chelation with BAPTA-AM indicated that P2X(7)-induced potassium depletion was independent of calcium mobilization. …”
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    K(+) regulates Ca(2+) to drive inflammasome signaling: dynamic visualization of ion flux in live cells
  19. 10159
    “…The results indicated that 500 μg/mL of CAE exhibited a reducing power of 94.7%, ferrous ion chelating activity of 46.4%, and hydroxyl radical scavenging activity of 20.3%. …”
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    Alleviation of Ultraviolet B-Induced Photodamage by Coffea arabica Extract in Human Skin Fibroblasts and Hairless Mouse Skin
  20. 10160
    “…The resultant N-heterocyclic phosphine five-membered ring adopts a half-chair conformation and features a tetra­coordinate P atom ligated by the chelating di­amine [P—N = 1.6348 (14) and 1.6192 (14) Å], one double-bonded O atom [P1—O1 = 1.4652 (12) Å] and one Cl atom [P1—Cl1 = 2.0592 (7) Å]. …”
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    Crystal structure of 2-chloro-1,3-bis­(2,6-diiso­propyl­phen­yl)-1,3,2-di­aza­phospho­lidine 2-oxide
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