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  1. 10181
    “…Resveratrol targets the pyruvate dehydrogenase (PDH) complex, a key mitochondrial gatekeeper of energy metabolism, leading to an enhanced PDH activity. Calcium chelation, as well as the blockade of the mitochondrial calcium uniport, prevents the resveratrol-induced augmentation in oxidative capacities and the increased PDH activity suggesting that calcium might play a role in the metabolic shift. …”
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    Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells
  2. 10182
    “…Oxidative stress could be a result of a breakdown in metal-ion homeostasis which leads to abnormal metal protein chelation. In our previous work, we reported a strong correlation between Alzheimer's disease and oxidative stress. …”
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    Preliminary Data on the Interaction between Some Biometals and Oxidative Stress Status in Mild Cognitive Impairment and Alzheimer's Disease Patients
  3. 10183
    “…Specifically, disulfiram, an inactive (64)Cu ligand, was first injected to allow it to metabolize into diethyldithiocarbamate (DDC), a strong (64)Cu ligand, which can chelate (64)CuCl(2) from the following injection to form the actual PET tracer in situ. …”
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    Synthesis-free PET imaging of brown adipose tissue and TSPO via combination of disulfiram and (64)CuCl(2)
  4. 10184
    “…Results indicate that clinically relevant quinolones interact with the enzyme through a water–metal ion bridge in which a noncatalytic divalent metal ion is chelated by the C3/C4 keto acid of the drug. In contrast to other bacterial type II topoisomerases that have been examined, the bridge is anchored to gyrase primarily through a single residue (Ser85). …”
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    Interactions between Quinolones and Bacillus anthracis Gyrase and the Basis of Drug Resistance
  5. 10185
    “…In this study, we showed that the protein encoded by ARABIDOPSIS THALIANA PLANT DEFENSIN TYPE 1.1 (AtPDF1.1) is a secreted protein that can chelate apoplastic iron. Transcripts of AtPDF1.1 were induced in both systemic non-infected leaves of Arabidopsis thaliana plants and those infected with the necrotrophic bacterium Pectobacterium carotovorum subsp. carotovorum (Pcc). …”
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    The Arabidopsis defensin gene, AtPDF1.1, mediates defence against Pectobacterium carotovorum subsp. carotovorum via an iron-withholding defence system
  6. 10186
    “…Beginning from day 100, mice were treated with deferiprone (DFP), a ferric chelator that is able to cross the blood–brain barrier and is currently used in clinics as treatment for hemosiderosis. …”
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    Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein Aggregation
  7. 10187
    por Priyadarshini, E., Pradhan, N.
    Publicado 2017
    “…The free –COO(−) groups on GNP surface interacted with Pb(2+) and ion-dependent chelation mechanism lead to cross-linking of particles and subsequent agglomeration. …”
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    Metal-induced aggregation of valine capped gold nanoparticles: An efficient and rapid approach for colorimetric detection of Pb(2+) ions
  8. 10188
    “…Therefore, in this study, we successfully labeled AGuIX with (64)Cu through the convenient built-in chelator. The biodistribution studies indicated that the radiotracer (64)Cu-AGuIX accumulates to high levels in the HepG2 xenograft of nude mice, suggesting that it would be a potential theranostic nanoprobe for image-guided radiotherapy in HCC. …”
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    Evaluation of Novel (64)Cu-Labeled Theranostic Gadolinium-Based Nanoprobes in HepG2 Tumor-Bearing Nude Mice
  9. 10189
    “…For biological effects, antioxidant (DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, and metal chelating assays), enzyme inhibitory (against cholinesterase, tyrosinase, α-amylase and α-glucosidase), antimicrobial, DNA protection and cytotoxic abilities were tested. …”
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    A Multidirectional Perspective for Novel Functional Products: In vitro Pharmacological Activities and In silico Studies on Ononis natrix subsp. hispanica
  10. 10190
    por Kang, Kyung Wook, Park, Won-Ju
    Publicado 2017
    “…As evident from the workplace environmental monitoring, the level of lead exposure in the air exceeded its limit (0.015–0.387 mg/m(3)). He received chelation treatment with calcium-disodium ethylenediaminetetraacetic acid (1 g/day) for 5 days without any adverse effects. …”
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    Lead Poisoning at an Indoor Firing Range
  11. 10191
    “…Asp95 is located at the threefold central channel of the trimeric Dut where it chelates a divalent ion. Here, using state-of-the-art techniques, we demonstrate that D95E mutation has an epistatic effect on the motifs involved in Stl binding. …”
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    Dissecting the link between the enzymatic activity and the SaPI inducing capacity of the phage 80α dUTPase
  12. 10192
    “…The coordination plane of the Pd(II) atom shows a slight tetra­hedral distortion from square-planar, as indicated by the dihedral angle between the PdCl(2) and PdN(2) planes of 4.19 (8)°. The chelate ring is folded along the N⋯N vector by 7.1 (1)°.…”
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    Crystal structure of unsymmetrical α-di­imine palladium(II) complex cis-[{ArN=C(Me)–(Et)C=NAr}PdCl(2)] [Ar = 2,6-(iPr)(2)C(6)H(3)]
  13. 10193
    “…From our results, it is clearly indicated that the free radical scavenging, metal chelating and antioxidant potentials of GSP might be the possible reason, responsible for the rescue action against Cd induced mitochondrial damage in the liver of rats.…”
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    Hepatoprotective effect of grape seed proanthocyanidins on Cadmium-induced hepatic injury in rats: Possible involvement of mitochondrial dysfunction, inflammation and apoptosis
  14. 10194
    “…Rats Wistar received Pb nitrate (50 mg/Kg/day, i.p., 5 days) followed by GA (13.5 mg/Kg, p.o., 3 days) or a chelating agent (EDTA, 55 mg/Kg, i.p.). As result, Pb decreased body weight, hematocrit and blood δ-aminolevulinic acid dehydratase (ALA-D) activity. …”
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    Antioxidant protection of gallic acid against toxicity induced by Pb in blood, liver and kidney of rats
  15. 10195
    “…The present study investigated the anti-P. aeruginosa activity of lin-SB056-1, a recently described semi-synthetic antimicrobial peptide, used alone and in combination with the cation chelator ethylenediaminetetraacetic acid (EDTA). Bactericidal assays were carried out in standard culture conditions and in an artificial sputum medium (ASM) closely resembling the CF environment. …”
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    The Semi-Synthetic Peptide Lin-SB056-1 in Combination with EDTA Exerts Strong Antimicrobial and Antibiofilm Activity against Pseudomonas aeruginosa in Conditions Mimicking Cystic Fibrosis Sputum
  16. 10196
    “…Despite the successful reduction of the MeHg concentration in the patient’s blood with erythrocyte apheresis and chelator therapy, his condition did not improve and led to a persistent vegetative state. …”
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    An Enigmatic Case of Acute Mercury Poisoning: Clinical, Immunological Findings and Platelet Function
  17. 10197
    “…In this assay, mitotic chromosomes are first expanded in a hypotonic buffer containing a Mg(2+)-chelating agent and then converted into different shapes in a NaCl concentration-dependent manner. …”
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    Condensin II plays an essential role in reversible assembly of mitotic chromosomes in situ
  18. 10198
    “…Gintonin-mediated mobilization of [Ca(2+)](i) was attenuated by LPA1/3 receptor antagonist Ki16425, phospholipase C inhibitor U73122, inositol 1,4,5-triphosphate receptor antagonist 2-APB, and intracellular Ca(2+) chelator BAPTA-AM. Gintonin facilitated in vitro wound healing in a concentration-dependent manner. …”
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    Gintonin, an exogenous ginseng-derived LPA receptor ligand, promotes corneal wound healing
  19. 10199
    “…Some hydrophobic amino acids chelate FeS nanocrystals, producing three positive feedbacks: (i) an increase in catalytic surface area; (ii) partitioning of FeS nanocrystals to the membrane; and (iii) a proton-motive active site for carbon fixing that mimics the enzyme Ech. …”
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    The origin of heredity in protocells
  20. 10200
    “…In spite of appreciable research efforts, high-affinity copper chelators suitable for brain imaging applications are still lacking. …”
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    Coordination Chemistry of Bifunctional Chemical Agents Designed for Applications in (64)Cu PET Imaging for Alzheimer’s Disease
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