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10541por Alli, Abdel A., Yu, Ling, Wlazlo, Ewa, Kasem, Sadat, Gholam, Mohammed F., Desai, Dhruv, Lugo, Carlos I., Vaulont, Sophie, Scindia, Yogesh M.“…ENaC activity in cultured Xenopus 2F3 cells and mpkCCD cells was inhibited by iron, which could be reversed by iron chelation. Thus, our novel findings implicate iron as a regulator of ENaC protein and its activity.…”
Publicado 2022
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10542por Lin, Jian-Hong, Yang, Kun-Ta, Lee, Wen-Sen, Ting, Pei-Ching, Luo, Yu-Po, Lin, Ding-Jyun, Wang, Yi-Shun, Chang, Jui-Chih“…The results from the present study show that XN was able to protect cardiomyocytes against Fe-SP- and RSL3-induced ferroptotic cell death by decreasing the production of lipid peroxidation and ROS, chelating iron, reducing the NRF2 protein level, and modulating the protein levels of GPX4. …”
Publicado 2022
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10543“…The amino nitrogen atom and carboxyl oxygen atom of the functional groups on the surface of the FNs were the main binding sites for the chelation of Ca(II). The size of the FNs-Ca(II) complex was about 4.75 nm, and the specific signal peak of calcium at 3.7 keV was observed in its energy dispersive X-ray spectroscopy spectrum. …”
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10544“…Different strategies including the exogenous use of micronutrient-chelated amino acids are being employed for better crop yield with limited fresh water for irrigation. …”
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10545por McMillen, Shasta, Thomas, Sydney, Liang, Emily, Nonnecke, Eric B., Slupsky, Carolyn, Lönnerdal, Bo“…To generate hypotheses on how changes to the gut microbiota by iron adversely affect development, and to determine whether the form of iron influences microbiota outcomes, we characterized gut microbiome and metabolome changes in Sprague-Dawley rat pups given oral supplements of ferrous sulfate (FS), ferrous bis-glycinate chelate (FC), or vehicle control (CON) on postnatal day (PD) 2–14. …”
Publicado 2022
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10546por Karunakaran, Gopalu, Cho, Eun-Bum, Kumar, Govindan Suresh, Kolesnikov, Evgeny, Sudha, Kattakgoundar Govindaraj, Mariyappan, Kowsalya, Han, Areum, Choi, Shin Sik“…Citric acid was used as a chelating and modifying agent for tuning the structure and porosity of the HAp structure. …”
Publicado 2022
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10547por Wang, Xiao, Zheng, Xianghong, Liu, Xinyu, Zeng, Birong, Xu, Yiting, Yuan, Conghui, Dai, Lizong“…Due to unique chelating and macrocyclic effects, crown ether compounds exhibit wide application prospects. …”
Publicado 2022
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10548por Punia Bangar, Sneh, Singh Sandhu, Kawaljit, Trif, Monica, Rusu, Alexandru, Pop, Ioana Delia, Kumar, Manoj“…Extrusion increased antioxidant activity (AOA), metal chelating activity (MCA), and ABTS(+) scavenging activity, whereas total phenolic content (TPC) and total flavonoids content (TFC) decreased. …”
Publicado 2022
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10549por Wen, Ying, Wang, Ying, Chen, Shouwen, Zhou, Xiangshan, Zhang, Yuanxing, Yang, Dahai, Núñez, Gabriel, Liu, Qin“…Moreover, we observed that the dysregulation of c-di-GMP in E. piscicida promotes iron accumulation, mitochondrial dysfunction, and production of reactive oxygen species, all of which that can be blocked by iron chelator. Importantly, unlike classical ferroptosis that is executed via excess lipid peroxidation, no lipid peroxidation was detected in the infected cells. …”
Publicado 2022
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10550“…Samples were evaluated for their total contents of phenolics and flavonoids, as well as several in vitro methods of antioxidant activities, namely, free radical scavenging and metal chelation activities. Moreover, anti-tyrosinase and antiglycation properties, as well as inhibitory activities against LDL cholesterol oxidation and DNA damage, were examined. …”
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10551por Chen, Hsin-Chih, Tang, Han-Hsuan, Hsu, Wei-Hsiang, Wu, Shan-Ying, Cheng, Wen-Hsing, Wang, Bao-Yuan, Su, Chun-Li“…Using a ferroptosis-specific inhibitor and iron chelator, the vulnerability of triple-negative breast cancer (TNBC) MDA-MB-231 cells to ferroptosis was identified and compared to that of luminal A MCF-7 cells. …”
Publicado 2022
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10552por Al-Muhanna, Afnan Fahd“…Many pathological studies have reported a direct correlation between T1 signal changes and gadolinium deposition in human and animal autopsy specimens, which raised concerns on the use of GBCAs, particularly with linear chelators. The association between gadolinium accumulation and occurrence of physical and neurological side effects or neurotoxic damage has not yet been conclusively demonstrated. …”
Publicado 2022
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10553por Karabacak, Soner, Palaniappan, Alagappan, Tony, Tsang Siu Hon, Edwin, Teo Hang Tong, Gulyás, Balázs, Padmanabhan, Parasuraman, Yildiz, Ümit Hakan“…The Pdots were post-functionalized by 1,4,7,10 tetraazacyclododecane-1,4,7,10-tetraacetic acid for chelating gadolinium nanoparticles (Gd(3+)) that provide magnetic properties to the Pdots. …”
Publicado 2022
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10554por López-García, Guadalupe, Dublan-García, Octavio, Arizmendi-Cotero, Daniel, Gómez Oliván, Leobardo Manuel“…Peptides with antioxidant properties exert effective metal ion (Fe(2+)/Cu(2+)) chelating activity and lipid peroxidation inhibition, which may lead to notably beneficial effects in promoting human health and food processing. …”
Publicado 2022
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10555por Cui, Baihui, Chen, Zhihua, Wang, Feihua, Zhang, Zihan, Dai, Yanran, Guo, Dabin, Liang, Wei, Liu, Yu“…According to the findings obtained, a three-step mechanism of Cr(VI) removal by MBTS was further put forward, i.e., (1) Cr(VI) exchanged with hydroxyl groups on MBTS, (2) the reduction in Cr(VI) to Cr(III) mediated by oxygen-containing groups, and (3) the chelation of produced Cr(III) with the amino groups on MBTS. …”
Publicado 2022
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10556“…The activation of cell signalling proteins was then evaluated in capsaicin- or zinc treated cells in the presence or absence of cell-permeant calcium chelator (BAPTA-AM) and the CAMKK inhibitor (STO-609). …”
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10557por Ku, Yee-Shan, Cheng, Sau-Shan, Cheung, Ming-Yan, Niu, Yongchao, Liu, Ailin, Chung, Gyuhwa, Lam, Hon-Ming“…In plants, alkaloids, phytohormones, ion chelators, and flavonoids have been reported to be the substrates of MATE transporters. …”
Publicado 2022
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10558“…To overcome this, microbes have evolved multiple iron uptake strategies, a common one of which is through the secretion of siderophores, which are iron-chelating metabolites generated endogenously. Siderophore-mediated iron transport, a standby when default iron transport routes are abolished under iron rich conditions, is essential under iron starvation conditions. …”
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10559“…Complexes OsH(3){κ(2)-N,O-[HNC(O)R]}(P(i)Pr(3))(2) dissociate the carbonyl group of the chelate to afford κ(1)-N-amidate derivatives, which coordinate the nitrile. …”
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10560“…Especially regarding antioxidation, Myr is capable of not only chelating intracellular transition metal ions for removing reactive oxygen species, but also of activating antioxidant enzymes and related signal pathways and, thus, of sustainably scavenging radicals. …”
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