“…The optical properties and the formation kinetics of the BODIPY-based MCCs and the BODIPY-supported micelle chelator aggregates (MCAs) are presented as well. The presented data provide additional insights into the structural and formation aspects of both the traditional and newly obtained micellar coordination clusters for their future optimization, control, and application. …”
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“…Using 2-photon imaging of myelinic Ca in live ex vivo mouse optic nerves, we show that Cu ions potently modulate Ca levels in an NMDAR-dependent manner. Chelating Cu in the perfusate induced a substantial increase in Ca levels, and also caused significant axo-myelinic injury. …”
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“…A cell permeable Zn chelator demonstrated that Zn is essential for IL-1 β /TNF- α signaling. …”
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“…All the samples also showed antioxidant properties (reducing property, 2,2′-azino-bis (-3-ethylbenzthiazoline-6-sulphonate [ABTS*] and 1,1-diphenyl-2-picrylhydrazyl [DPPH] free radicals scavenging abilities, and Fe(2+) chelating ability). Therefore, combinations of GA with acarbose could be employed as antidiabetic therapy, with a possible reduction of side effects of acarbose; nevertheless, the combination of 50% acarbose and 50% GA seems the best.…”
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“…This study aimed to elucidate whether zinc deficiency induced by treatment with N, N, N′, N′-tetrakis (2-pyridylmethyl) ethylenediamine (TPEN), a zinc chelator, affects and alters autophagy activity. In cell viability assays, TPEN showed cytotoxicity in HT-22 cells. …”
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“…The presence of the hemilabile N-ligand contributed to stabilize the ensuing Au(iii) species acting as a five-membered ring chelate upon its coordination to the metal center. …”
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“…The application of synthetic Fe-chelates stands for the most established agronomical practice to alleviate lime-induced chlorosis, which still constitutes a major agronomic problem. …”
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“…We assessed the potential of α-lipoic acid (ALA) as an iron chelator, antioxidant and anti-inflammatory agent in both in vitro and in vivo models of iron overload. …”
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“…We explored that biofilm formation and cell adherence to polystyrene surface as well as human oral epithelial cells were considerably reduced under iron deprivation both in presence of 2,2 BP (iron chelator) and siderophore mutant Δ011-14 strain. We further investigated that the potency of three first line anti-TB drugs (Isoniazid, Ethambutol, Rifampicin) to inhibit both biofilm formation and cell adhesion were enhanced under iron deprivation in contrast to the drugs when tested alone. …”
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“…RESULTS: The TPC@M2 NPs can on-demand release TA molecules to chelate excessive Fe(2+), while acid-responsively liberating CAT to synergistically scavenge multiple ROS (·OH, ·O(2)(−), and H(2)O(2)). …”
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“…This allowed for the identification of features that provide larger contributions to complex stability, which will be very helpful for the design of efficient chelators for Mn(II) complexation. This issue is particularly important to develop Mn(II) complexes for medical applications, for instance, as magnetic resonance imaging (MRI) contrast agents. …”
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“…The central copper(II) atom of the title salt, {[Cu(CF(3)SO(3))(CH(3)CN)(2)(C(12)H(12)N(2)O(2))](CF(3)SO(3))}( n ) or [[Cu(CH(3)CN)(2)(diOMe-bpy)(CF(3)SO(3))](CF(3)SO(3))]( n ) where diOMe-bpy is 4,4′-dimeth­oxy-2,2′-bi­pyridine, C(12)H(12)N(2)O(2), is sixfold coordin­ated by the N atoms of the chelating bi­pyridine ligand, the N atoms of two aceto­nitrile mol­ecules, and two tri­fluoro­methane­sulfonate O atoms in a tetra­gonally distorted octa­hedral shape. …”
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“…Two DNBA anions monodentately coordinate the Cd(II) atom through an oxygen atom of the carboxyl­ate group while two en mol­ecules coordinate in a chelate fashion, resulting in a distorted O(2)N(4) coordination set. …”
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“…We have previously shown that pUL89‐C can be pharmacologically inhibited with designed metal‐chelating compounds. We report herein the synthesis of a few 8‐hydroxy‐1,6‐naphthyridine subtypes, including 5‐chloro (subtype 15), 5‐aryl (subtype 16), and 5‐amino (subtype 17) variants. …”
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“…In this work, we developed and formulated a novel hybrid gold nanoparticle system in which a gold salt (HAuCl(4)) is combined with dotarem, an MRI contrast agent (DOTA) by chelation (Method IN) and stabilized by a lactose-modified chitosan polymer (CTL; Chitlac) to form DOTA IN-CTL AuNPs. …”
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“…The results showed that dipole-salt is the main form of Leu in the physiological condition. Leu exhibits high chelating potential towards both Fe(III)/Fe(II) and Cu(II)/Cu(I) ions with the most favourable coordinating positions at two oxygen atoms of the –COO functional group. …”
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“…Gene pathways associated with active tolerance in Xenopus, including some involved in metal ion binding and hypoxia, are found to be conserved across species, including mammals, and administration of a metal chelator (deferoxamine) or a HIF‐1α agonist (1,4‐DPCA) in embryos infected with lethal A. hydrophila increased survival despite high pathogen load. …”
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“…Thus, Memo1 appears to act as a Cu(I) chelator (perhaps shuttling the metal ion to Atox1 and the secretory path) that protects cells from Cu-mediated toxicity, such as uncontrolled formation of ROS. …”
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“…The results of this study show that GSH is a potent chelator that binds copper and enables its elimination from the body. …”
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“…Experiments with a high affinity Cu(I) chelator demonstrate that Cu(I) transfer from Cu(I)-BsCsp3 must occur via an associative mechanism. …”
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