“…We propose that the simple insertion of a polyhistidine tag into exposed flexible loops on the ferritin surface (His-Fer) can mitigate the need for complex purifications and enable facile metal-chelate-based purification, thereby allowing for optimization of early stage vaccine candidates. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It is capable of inhibiting lipid peroxidation through iron chelation, reducing iron-related free radical generation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In our preclinical intervention study, we tested potential disease-alleviating effects upon prophylactic oral application of the iron-chelating compound desferoxamine (DESF) in acute murine campylobacteriosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The antioxidant activities of all samples were determined in terms of DPPH radical scavenging activity, reducing power, metal-chelating activity, and linoleic acid peroxidation assay. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The OPT-TP, OPT-LUT, and OPT-RSA, as well as the most efficient NADES-based extract, PG-50-TP, were excellent antioxidants and Fe(2+) ion chelators. In addition, they were potent inhibitors of collagenase and hyaluronidase, as well as good significant anti-elastase and -lipoxygenase activity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The results show the successful formulation strategy that turns the ultrasound contrast PVA-shelled microbubbles into a microdevice, exhibiting good loading efficiency of Yttrium cargo by complexation with a bifunctional chelator. The selective targeting of Yttrium-loaded MBs on the glioblastoma-associated tumor endothelial cells can be unlocked by the biorecognition between the overexpressed α(V)β(3) integrin and the ligand Cyclo(Arg-Gly-Asp-D-Phe-Lys) at the PVA microbubble surface. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The methods used to evaluate the activity of the compounds were radical scavenging, reduction of oxidizing reagents and transition metals’ ions chelation assays. Quantum descriptors were also calculated in order to evaluate the influence of substituents and their position on the activity of the compounds. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The results indicate that indole-imidazole derivatives with alkyl substituent exhibit an excellent cytoprotective effect against AAPH-induced oxidative hemolysis and act as effective ferrous ion chelating agents. The indole-imidazole compound with chlorine atoms inhibited the growth of fungal strains: Coriolus versicolor (Cv), Poria placenta (Pp), Coniophora puteana (Cp), and Gloeophyllum trabeum (Gt). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These results identify the new role for Atp7b in developing brain and identify metabolic changes that could be exacerbated by Cu chelation therapy.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…When the catalyst is modified by the addition of a chelating bisphosphine ligand (dppp), an organic base (Cy(2)NMe), sodium acetate, and aryl triflates are used as electrophiles, the α-arylation pathway is promoted preferentially. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The antioxidant capacity of the compounds was analyzed using a ferrous ion chelating activity assay. The ability of the derivatives to protect RBC from oxidative damage, including the oxidation of hemoglobin to methemoglobin, was assessed using a water-soluble 2,2′-azobis(2-methyl-propionamidine) dihydrochloride (AAPH) as a standard inducer of peroxyl radicals. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…More water-solubilized pectin fractions with a high molecular mass were found in the kiwifruit puree, leading to its high viscosity and large particle size, but a more chelator-solubilized pectin fraction with a low esterification degree was observed in the orange juice, resulting in its cloud loss. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Amongst other cytoprotective properties, ET was shown to scavenge ROS, decrease proinflammatory mediators, and chelate metal cations, including Fe(2+), preventing them from partaking in redox activities, and may protect against mitochondrial damage and dysfunction. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The EO was extracted using steam distillation, and its chemical composition was analyzed using GC-MS, while the antioxidant activity was evaluated using the radical, scavenging capacity (DPPH and ABTS assays), and ferric reducing antioxidant power (FRAP) assays, ferrous ion chelating (FIC) activity, and the Rancimat test. The antibacterial activity against Staphylococcus aureus, Escherichia coli, and Salmonella infantis was studied using the agar well diffusion method. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the present investigation, this feature was targeted in diethyl nitrosamine-phenobarbital-induced hepatocellular carcinoma (HCC) in a rat model system by an established anticancer drug, 5-FU, co-administered with copper and its chelating agent, disulfiram. After treatment with the test chemicals in HCC-induced rats, blood and liver samples were subjected to biochemical, molecular, and histopathological analyses. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: The development of neurological symptoms in patients with purely hepatic WD was closely associated with insufficient doses of PCA and ZG, and the inferior efficacy of copper-chelating agents. During the course of anti-copper treatment, the patient's medical status and the efficacy of copper excretion should be closely monitored.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Further in silico and experimental studies revealed that it represents an overlooked metal dependent-sugar epimerase family bearing vicinal oxygen chelate (VOC) architecture.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The Chilean census of 2017 reported that 11.4% of the local population are 65 years or older, and according to the National Institute of Statistics (INE) the current expectancy of life in Chile is 76 years for men and 81 years for women respectively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this study, we aimed to evaluate the frequency of midpalatal maturational stages in a Chilean urban sample of adolescents, post-adolescents and young adults, associated with chronological age and sex, by assessing CBCT scan images. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We also isolated M. chelonae, M. canariasense, and M. jacuzzii, which are rarely reported. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso