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1061por Caruffo, Mario, Mandakovic, Dinka, Mejías, Madelaine, Chávez-Báez, Ignacio, Salgado, Pablo, Ortiz, Daniela, Montt, Liliana, Pérez-Valenzuela, Javiera, Vera-Tamargo, Francisca, Yánez, José Manuel, Wacyk, Jurij, Pulgar, Rodrigo“…The aim of this work was to use the iron chelator Deferiprone (DFP) as HDAD to treat SRS. Here, we describe the protective effect of the iron chelator DFP over P. salmonis infections at non-antibiotic concentrations, in bacterial challenges both in vitro and in vivo. …”
Publicado 2020
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1062por Saha, Piu, Yeoh, Beng San, Xiao, Xia, Golonka, Rachel M., Abokor, Ahmed A., Wenceslau, Camilla F., Shah, Yatrik M., Joe, Bina, Vijay-Kumar, Matam“…Ent-induced IL-8 secretion was dependent on chelation of the labile iron pool and on the levels of intracellular Lcn2. …”
Publicado 2020
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1063por Nassar, Mohannad, Hiraishi, Noriko, Islam, Md. Sofiqul, Romero, Maria JRH., Otsuki, Masayuki, Tagami, Junji“…RESULTS: The µTBS values of the control and NaOCl with chelator groups were not significantly different, but were all significantly higher than that of the group treated with NaOCl only. …”
Publicado 2020
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1064por Ucuncu, Ekin, Rajamani, Karthyayani, Wilson, Miranda S. C., Medina-Cano, Daniel, Altin, Nami, David, Pierre, Barcia, Giulia, Lefort, Nathalie, Banal, Céline, Vasilache-Dangles, Marie-Thérèse, Pitelet, Gaële, Lorino, Elsa, Rabasse, Nathalie, Bieth, Eric, Zaki, Maha S., Topcu, Meral, Sonmez, Fatma Mujgan, Musaev, Damir, Stanley, Valentina, Bole-Feysot, Christine, Nitschké, Patrick, Munnich, Arnold, Bahi-Buisson, Nadia, Fossoud, Catherine, Giuliano, Fabienne, Colleaux, Laurence, Burglen, Lydie, Gleeson, Joseph G., Boddaert, Nathalie, Saiardi, Adolfo, Cantagrel, Vincent“…In mutant cells, higher IP(6) level is expected to be associated with an increased chelation of intracellular cations, such as iron or calcium, resulting in decreased levels of available ions. …”
Publicado 2020
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1065por Susanah, Susi, Idjradinata, Ponpon S., Sari, Nur M., Rakhmilla, Lulu E., Sribudiani, Yunia, Trisaputra, Jessica O., Moestopo, Octawyana“…Indication to start iron chelation therapy is based on serum ferritin (SF) or transferrin saturation (TS) level or the amount of transfusion. …”
Publicado 2020
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1066por Yang, Hua, Gao, Feng, McNeil, Brooke, Zhang, Chengcheng, Yuan, Zheliang, Zeisler, Stefan, Kumlin, Joel, Zeisler, Jutta, Bénard, François, Ramogida, Caterina, Schaffer, Paul“…Development of stable chelators is essential to harness the potential of this isotope, challenged by the presence of endogenous copper chelators. …”
Publicado 2021
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1067“…Iron chelators may consequently be of high therapeutic value during the present COVID-19 pandemic.…”
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1068“…Supported lipid bilayers (SLBs) are one of the most common cell-membrane model systems to study cell-cell interactions. Nickel-chelating lipids are frequently used to functionalize the SLB with polyhistidine-tagged ligands. …”
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1069“…Both compounds showed moderate activity towards planktonically growing P. aeruginosa cells, and the mechanism of action of these chelators was indeed by limiting the amount of free iron. …”
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1070“…The antimicrobial activity of multiple iron chelators and gallium-based therapies against different bacterial species has been characterized in preclinical studies. …”
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1071por Cahill, Christina, O’Connell, Fiona, Gogan, Karl M., Cox, Donal J., Basdeo, Sharee A., O’Sullivan, Jacintha, Gordon, Stephen V., Keane, Joseph, Phelan, James J.“…These results provide insight, and an in vitro proof-of-concept, that iron chelators may prove an effective adjunctive therapy in combination with current tuberculosis antimicrobials.…”
Publicado 2021
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1072“…The boron chelation of the chelating fabric was evaluated in a batch mode. …”
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1073por Mariscal, Michael. G., Berry-Kravis, Elizabeth, Buxbaum, Joseph D., Ethridge, Lauren E., Filip-Dhima, Rajna, Foss-Feig, Jennifer H., Kolevzon, Alexander, Modi, Meera. E., Mosconi, Matthew W., Nelson, Charles A., Powell, Craig M., Siper, Paige M., Soorya, Latha, Thaliath, Andrew, Thurm, Audrey, Zhang, Bo, Sahin, Mustafa, Levin, April R.“…BACKGROUND: Phelan-McDermid Syndrome (PMS) is a rare condition caused by deletion or mutation of the SHANK3 gene. …”
Publicado 2021
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1074por Nuzzi, Raffaele, Geronazzo, Giada, Tridico, Federico, Nuzzi, Alessia, Caselgrandi, Paolo, Piga, Antonio Giulio“…BACKGROUND: The aim of this study is to evaluate eye structures and function in patients receiving iron chelating therapy and to assess whether a correlation exists between the onset of ocular alterations and the intake of iron chelating drugs. …”
Publicado 2021
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1075“…The selective removal of Zn(2+) from proteins by using a synthetic chelator is a promising therapeutic approach for the treatment of various diseases including cancer. …”
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1076“…Because symptoms are generally related to the liver, chelating agents capable of capturing excess copper ions after targeted delivery to the liver are highly required for the treatment of WD. …”
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1077“…The aim was to understand the influence and relative importance of the manufacturing conditions on mineral chelation and the subsequent pH stability of OTMs. …”
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1078por Tavassoli, Teresa, Layton, Christina, Levy, Tess, Rowe, Mikaela, George-Jones, Julia, Zweifach, Jessica, Lurie, Stacey, Buxbaum, Joseph D., Kolevzon, Alexander, Siper, Paige M.“…Phelan–McDermid syndrome (PMS) is one of the most common genetic forms of autism spectrum disorder (ASD). …”
Publicado 2021
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1079por Jiménez, Josué, Avellanal-Zaballa, Edurne, Serrano, Sergio, Torres, Alexis R., Agarrabeitia, Antonia R., Moreno, Florencio, Muller, Gilles, Bañuelos, Jorge, Maroto, Beatriz L., de la Moya, Santiago“…The prominent influence of the molecular symmetry, as defined by the symmetry point group, on the chiroptical behavior (electronic circular dichroism and, especially, circularly polarized luminescence) of simple fluorescent boron chelates (BODIPY and related BOPHY analogues) is studied and discussed. …”
Publicado 2020
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1080por Kucuk, Meltem, Tunca, Yasar-Meric, Erdem, Onur, Cetinkaya, Serdar, Demirkaya, Kadriye“…BACKGROUND: The heating of chelating agents such as EDTA increases dentin wettability by decreasing surface tension. …”
Publicado 2021
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