“…Here, using mouse eggs, we showed that basal concentrations of labile Zn(2+) are indispensable for sperm-initiated Ca(2+) oscillations because Zn(2+)-deficient conditions induced by cell-permeable chelators abrogated Ca(2+) responses evoked by fertilization and other physiological and pharmacological agonists. …”
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“…The dissolution of DES significantly decreased fiber crystallinity and increased the number of hydroxyl group (amorphous regions increased), thus improving the chelation reaction of Cu(2+), which was favorable for surface adsorption. …”
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“…METHODS: Reactive oxygen species scavenging (hydroxyl radical, hydrogen peroxide, and nitrogen oxide) and antioxidant capacity (2,2-diphenyl-1-picrylhydrazyl radical and ferrous ion chelating assays) of agomelatine were marked. Agomelatine's antiglycoxidation properties were assayed in sugars (glucose, fructose, and galactose) and aldehydes- (glyoxal and methylglyoxal) glycated bovine serum albumin (BSA). …”
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“…Radiochemical isolation of the produced radioscandium was performed with extraction chromatography using branched DGA resin and apparent molar activity was measured with the chelator DOTA. The imaging performance of (43)Sc and (44g)Sc was compared with (18)F, (68)Ga, and (64)Cu on two clinical PET/CT scanners. …”
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“…The antibacterial activity of chelated silver in the nanoclusters was found to be significantly higher compared to the activity of free silver ions. …”
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“…Depletion of polydopamine on excessive reactive oxygen species production, promotion of ATP production and anti‐inflammation by NAD(+) replenishment, and chelation of BAPTA (generated by BA‐AM hydrolysis) on overloaded Ca(2+) can comprehensively block the three stages of sepsis, i.e., precisely inhibit the activation of pyroptosis pathway (NF‐κB‐NLRP3‐ASC‐Casp‐1), inflammation pathway (IL‐1β, IL‐6, and TNF‐α), and mitochondrial apoptosis pathway (Bcl‐2/Bax‐Cyt‐C‐Casp‐9‐Casp‐3), thereby restoring intracellular homeostasis, saving the cells in a state of “critical survival,” further reducing LPS‐induced systemic inflammation, finally restoring the organ functions. …”
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“…After the mother's discontinuation of use of the traditional medicine, the child was treated with symptomatic treatment and chelation therapy. Subsequently, the patient's blood lead level decreased significantly. …”
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“…Due to the N-substituted pyridyl cation attached to the porphyrin core, these porphyrin ligands were highly water-soluble and formed the corresponding Gd(III) chelates, Gd-1 and Gd-2. Gd-1 was sufficiently stable in neutral buffer, presumably due to the preferred conformation of the carboxylate-terminated anchors connected to nitrogen in the meta position of the pyridyl group helping to stabilize Gd(III) complexation by the porphyrin center. (1)H NMRD (nuclear magnetic relaxation dispersion) measurements on Gd-1 revealed high longitudinal water proton relaxivity (r(1) = 21.2 mM(–1) s(–1) at 60 MHz and 25 °C), which originates from slow rotational motion resulting from aggregation in aqueous solution. …”
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“…Compound 19 acted as a free radical scavenger and biometal chelator, crossed the blood–brain barrier, was not cytotoxic, and showed neuroprotective properties in a 6-hydroxydopamine cell model of Parkinson's disease. …”
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“…The lead compound was coupled to a chelator for radiolabeling, and subject to dimerization. …”
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“…In Fe-limiting situations, plants and soil microbes have used active strategies such as acidification, chelation, and reduction, which have an important role to play in enhancing soil iron availability to plants. …”
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“…The conventional method for the radiolabeling of nanobodies is non-specifically, which conjugates the radioisotope chelating group to the side chain ɛ-amine group of lysine or sulfhydryl of cysteine of nanobodies, with a shortcoming of produce of the heterogeneous radiotracer. …”
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“…In order to support this working hypothesis, we conjugated our previously described anti-PSCA monoclonal antibody (mAb) 7F5 with the bifunctional chelator CHX-A″-DTPA and subsequently radiolabeled it with the theranostic radionuclide (177)Lu. …”
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“…The readily dissolved EuL(−) species with a log β of ~11.2 is formed at alkaline pH. A six-membered chelate ring is the key motif in all solution structures. …”
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“…In this study, the synthesis of a new chiral copper complex, [Cu(2)(mXPhI)](4+/2+), based on an m-xylyl-bis(imidazole)-bis(benzimidazole) ligand containing a stereocenter with a benzyl residue directly bound on the copper chelating ring, is reported. Binding experiments show that the cooperation between the two metal centers is weak, probably due to steric hindrance given by the benzyl group. …”
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“…It remains a primary target for researchers to increase the silver ion adsorption capacity of the chelate resin. Herein, a series of flower-like thiourea–formaldehyde microspheres (FTFM) possessing diameters of 15–20 μm were prepared via a one-step reaction under acidic conditions, and the effects of the monomer molar ratio and reaction time on the micro-flower morphology, specific surface area, and silver ion adsorption performance were explored. …”
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“…At the same time, the increased reactive oxygen species (ROS) will accelerate the release and activation of the DSF prodrug and further chelate the released Cu(2+) to produce the noxious copper diethyldithiocarbamate complex, which causes cell apoptosis effectively. …”
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“…Studies have proven that ferroptosis is closely related to the development of IPF, and ferroptosis inhibitors can slow down the occurrence of IPF by chelating iron or reducing lipid peroxidation. For example, the ferroptosis inhibitor deferoxamine (DFO) was used to treat a mouse model of pulmonary fibrosis, and DFO successfully reversed the IPF phenotype and increased the survival rate of mice from 50% to 90%. …”
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“…Antioxidant activity analyses against DPPH, ABTS(+), and Fe(2+) chelation showed enhanced antioxidant activity of the β-CD-Rg5 inclusion complex. …”
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“…Herein, we report the triple-stranded Ln(2)L(3)-type lanthanide molecular quasi-lanterns, which are fabricated by the deprotonation self-assembly of a linear ligand featuring a β-diketone chelating claw and 2,2′-bipyridine (bpy) moiety with lanthanide ions (Ln = Eu(3+) and Dy(3+)). …”
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