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11301por Dey, Sunanda, Sil, Sayantan, Dutta, Basudeb, Naskar, Kaushik, Maity, Suvendu, Ray, Partha Pratim, Sinha, Chittaranjan“…Here, bdc(2–) links two Pb(II) centers and the aiz ligand binds the metal centers in two different manners: chelating and monodonating. Thus, polymerizations have taken place from the combination of mixed ligand system. …”
Publicado 2019
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11302por Sánchez-Férez, Francisco, Ejarque, Daniel, Calvet, Teresa, Font-Bardia, Mercè, Pons, Josefina“…The Pip ligand exhibited a chelate (3a) or a monodentate (4) coordination mode, but the Isonicotinamide (Isn) ligand is the one that promoted the arrangement of different structures and also mainly directs the formation of the 2D and 3D supramolecular assemblies. …”
Publicado 2019
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11303“…Unfortunately, the pilot clinical application of zinc chelator and/or ionophore strategy, such as the use of quinoline-based compounds, namely clioquinol and PBT2, has not yet been successful. …”
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11304por Bragueto Escher, Graziela, Cardoso Borges, Lorena do Carmo, Sousa Santos, Jânio, Mendanha Cruz, Thiago, Boscacci Marques, Mariza, Araújo Vieira do Carmo, Mariana, Azevedo, Luciana, M. Furtado, Marianna, S. Sant’Ana, Anderson, Wen, Mingchun, Zhang, Liang, Granato, Daniel“…Results showed that the hydroalcoholic extract (50:50 v/v) presented the highest total phenolic content (TPC), flavonoids, and antioxidant activity (ferric reducing antioxidant power (FRAP), total reducing capacity (TRC), and Cu(2+)/Fe(2+) chelating ability). Phenolic acids and flavonoids were quantified in the extract by LC-DAD, while 19 compounds were tentatively identified by ESI-MS/MS. …”
Publicado 2019
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11305“…Standard care for lower-risk 5q deletion [del(5q)] MDS patients with anemia remains supportive, consisting of red blood cell (RBC) transfusions, iron chelation therapy, and treatment with erythropoiesis-stimulating agents (ESAs) in the case of low serum erythropoietin levels. …”
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11306por Belgacemi, Randa, Luczka, Emilie, Ancel, Julien, Diabasana, Zania, Perotin, Jeanne-Marie, Germain, Adeline, Lalun, Nathalie, Birembaut, Philippe, Dubernard, Xavier, Mérol, Jean-Claude, Delepine, Gonzague, Polette, Myriam, Deslée, Gaëtan, Dormoy, Valérian“…Inhibition of HH signalling was achieved upon Shh chelation during epithelial cell differentiation. HH pathway core components localization was investigated in lung tissues from non-COPD and COPD patients. …”
Publicado 2019
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11307por David, Juliet, Muniroh, Muflihatul, Nandakumar, Athira, Tsuji, Mayumi, Koriyama, Chihaya, Yamamoto, Megumi“…Hg(2+)-upregulated MIP-2 expression was suppressed by NAC regardless of the time sequence of the treatment, suggesting that the suppressive role of NAC in Hg(2+)-induced inflammation manifests as a possible chelator and antioxidant/reactive oxygen species scavenger.…”
Publicado 2020
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11308“…Due to the different mechanisms of action between the copper chelators and zinc salts, transitioning could require a period of overlap and increased monitoring. …”
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11309por Wickstroem, Katrine, Karlsson, Jenny, Ellingsen, Christine, Cruciani, Véronique, Kristian, Alexander, Hagemann, Urs B., Bjerke, Roger M., Ryan, Olav B., Linden, Lars, Mumberg, Dominik, Brands, Michael, Cuthbertson, Alan“…TTCs consist of the alpha particle emitter thorium-227 complexed to a 3,2-hydroxypyridinone chelator conjugated to a tumor-targeting monoclonal antibody. …”
Publicado 2019
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11310por Cholet, Juliette, Decombat, Caroline, Vareille-Delarbre, Marjolaine, Gainche, Maël, Berry, Alexandre, Senejoux, François, Ripoche, Isabelle, Delort, Laetitia, Vermerie, Marion, Fraisse, Didier, Felgines, Catherine, Ranouille, Edwige, Berthon, Jean-Yves, Priam, Julien, Saunier, Etienne, Tourrette, Albert, Troin, Yves, Thebaud, Gilles, Chalard, Pierre, Caldefie-Chezet, Florence“…Its antioxidant capacities and iron-chelating activity were assessed. The extract was tested on THP-1 differentiation, reactive oxygen species (ROS) production by leukocytes, neutrophils chemotaxis, cytokines, PGE2 production, and NF-κB activation in PBMCs. …”
Publicado 2019
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11311por Shimizu, Riha, Fukuda, Hirotsugu, Kikuchi, Yuji, Yanaka, Hirokazu, Hata, Nobuhiro, Yamazaki, Masashi, Nakatani, Yuki, Tamura, Yuma, Yamakoshi, Seiko, Kawabe, Atsuhiko, Horie, Yasuto, Sugimura, Hiroyuki, Matsushita, Yasushi, Nakamoto, Takaaki, Yasu, Takanori“…Using the anticoagulants heparin and ethylene-diamine-tetraacetic acid (EDTA)-2Na which inhibits platelets and leukocytes by chelating Ca(2+), we were able to quantify leukocyte rheological activation by the subtraction of passage time of blood treated with both heparin and EDTA-2Na from that of blood treated with heparin only. …”
Publicado 2019
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11312por Poggi, Maurizio, Samperi, Irene, Mattia, Lorenza, Di Rocco, Arianna, Iorio, Cristina, Monti, Salvatore, Pugliese, Giuseppe, Toscano, Vincenzo“…Methods: We evaluated endocrine damages and the efficacy of iron chelation therapy in 102 patients affected by TM. AI was assessed by tetracosactide (Synacthen) 1 mcg iv (low-dose test, LDT) stimulation test. …”
Publicado 2020
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11313“…The potential of anti‐ZIP14 antibodies and zinc chelation as anti‐cachexia therapy may require testing in patients with cancer cachexia. …”
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11314por Esposito, Diletta, Dal Poggetto, Giovanni, Demont, Aurélie, Kraut, Nicolai, Miro, Agnese, Ungaro, Francesca, Laurienzo, Paola, Quaglia, Fabiana“…In summary, βCD association to zein is a novel strategy to expand applications in the oral delivery of iron bisglycinate and, prospectively, to micronutrient chelates.…”
Publicado 2020
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11315“…Thereafter, polydopamine was used to modify TAPAM, Fe(3)O(4) nanoparticles was grafted to the modified TAPAM by chelation, named template anion polyacrylamide-polydopamine-Fe(3)O(4) (TAPAM-PDA-Fe(3)O(4)). …”
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11316Gallic acid and MiADMSA reversed arsenic induced oxidative/nitrosative damage in rat red blood cells“…The present study was planned to evaluate the protective effects of a metal chelator, MiADMSA either alone or in combination with a natural antioxidant (gallic acid) for the reversal of arsenic induced oxidative damage in red blood cells. …”
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11317por Sorrentino, Francesco, Maffei, Laura, Caprari, Patrizia, Cassetta, Rita, Dell'Anna, Donatella, Materazzi, Stefano, Risoluti, Roberta“…Crucial points in the management of pregnancy in thalassemia are the iron chelation therapy before and during pregnancy, the antithrombotic prophylaxis, the management of transfusion therapy according to the modified transfusion requirement, a cardiologic monitoring for hemodynamic changes that expose an increased risk of heart failure. …”
Publicado 2020
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11318“…Other up-regulated proteins found during vanadate exposure were ABC transporters for methionine and iron, suggesting that cellular responses to vanadate toxicity may also induce changes in unspecific transport and chelation of vanadate.…”
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11319por Gil, Silvia, Solano, Eduardo, Martínez-Trucharte, Francesc, Martínez-Esaín, Jordi, Pérez-Berná, Ana J., Conesa, José Javier, Kamma-Lorger, Christina, Alsina, Mercè, Sabés, Manel“…Two adjuvant agents as gold nanoparticles (AuNP) and chelating tricine were tested as enhancers in cisPt treatment. …”
Publicado 2020
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11320por Jakubczyk, Anna, Ćwiek, Paula, Rybczyńska-Tkaczyk, Kamila, Gawlik-Dziki, Urszula, Złotek, Urszula“…The 3% addition of millet flour to the wafer formulation induced the highest antioxidant activity against DPPH, Fe(2+) chelation, and ACE inhibitory activity of hydrolysates (IC(50) = 191.04, 0.46, and 157.73 µg mL(−1), respectively). …”
Publicado 2020
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