“…Vanillic acid, therefore appears to enhance Cd stress tolerance by increasing metal chelation and sequestration, by upregulating antioxidant defense and glyoxalase systems, and by facilitating nutrient homeostasis.…”
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“…Treatment with copper chelator tetrathiomolybdate (TM) also alleviated renal fibrosis in vivo and in vitro. …”
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“…CONCLUSIONS AND IMPORTANCE: We report a case of bull's eye maculopathy in a patient with hereditary hemochromatosis with no previous exposure to iron chelators and no known inherited retinal dystrophy. …”
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“…Here we utilise iron oxide magnetic nanoparticles coated with the known calcium chelator, citrate, to create calcium-binding nanoparticles. …”
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“…Furthermore, calcium channel blockers, including verapamil and cadmium chloride, and the calcium chelator EGTA inhibited virus infection. Therefore, the transient intracellular calcium increase reported here may be an early signaling event associated with virus infection.…”
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“…Antioxidant, antiradical and metal chelating properties, inhibitory activity against tyrosinase and α-amylase enzymes were also evaluated. …”
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“…Depending on the pH, complexation involved a bidentate chelate, monodentate and bidentate bridging mode. …”
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“…Brassica incana extracts showed in vitro antioxidant properties; the leaf extract displayed greater radical scavenging activity in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) test than the flowering top extract (IC(50) = 1.306 ± 0.049 mg/mL and 2.077 ± 0.011 mg/mL), which in turn had a stronger ferrous ion chelating ability than the other (IC(50) = 0.232 ± 0.002 mg/mL and 1.147 ± 0.016 mg/mL). …”
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“…In contrast, for the pyridine sulfinate, a chelated Pd(II) sulfinate complex formed post-transmetalation is the resting-state intermediate, and loss of SO(2) from this complex is turnover-limiting. …”
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“…In addition, our biochemical data show that high concentrations of ATP promote the formation of metal ion-ATP chelates. This reduces the concentration of free metal ion available for the catalytic reaction, and thus further inhibits the enzymatic activity. …”
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“…Interestingly, ketamine- or sevoflurane-induced cognitive deficits, very likely, resulted from a novel iron-dependent regulated cell death, ferroptosis. Notably, iron chelator deferiprone attenuated the GA-induced mitochondrial dysfunction, ferroptosis, and further cognitive deficits. …”
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“…In GBCAs gadolinium (Gd) is present in a bound chelated form. Gadolinium is a rare-earth element, which is normally not present in human body. …”
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“…. • Beta-thalassaemia major is fatal in the first few years of life unless regular blood transfusions are given; unless they are accompanied by iron chelation, these transfusions will eventually cause death due to irreversible organ damage from iron overload. • Malarial anaemia is a particular problem for children and pregnant women and severe anaemia can be caused by P. falciparum and P. vivax. …”
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“…The virions of several species are degraded by CsCl and are unstable in high salt concentration, resist moderately high temperatures and organic solvents, but are sensitive to RNase and chelation. Regardless of the genome type, monopartite or fragmented, virions contain a single molecule of linear, positive sense, single stranded RNA, constituting 5–6% of the particle weight. …”
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“…Ratiometric Ca(2+) imaging showed significantly increased presynaptic Ca(2+) induced by G85R-SOD1 that preceded synaptic dysfunction. Chelating Ca(2+) using EGTA prevented synaptic inhibition by G85R-SOD1, confirming the role of aberrant Ca(2+) in mediating G85R-SOD1 toxicity. …”
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“…The quenching process displays a linear response over variable Cu(II) concentration (0.05–5 mM) that affords reliable detection of low level Cu(II) levels by an in situ “turn-off” process. The tweezer-like chelation properties of CS-Ac-An with Cu(II) was characterized by complementary spectroscopic methods: IR, NMR, X-ray photoelectron (XPS), and scanning electron microscopy (SEM). …”
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“…The biological activities of these extracts were also evaluated in terms of their antioxidant activities (2,2-diphenyl-1-picrylhydrazyl DPPH, 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid ABTS, Ferric Reducing Antioxidant Power Assay FRAP, cupric ion reducing antioxidant capacity CUPRAC, β-carotene, phosphomolybdenum, and metal chelating) and enzyme inhibitory properties (against acetylcholinesterase, butyrylcholinesterase, and tyrosinase). …”
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“…In rabbit chow, the calcium content had to be reduced 5-fold to minimize chelation of doxycycline and deliver adequate oral bioavailability. …”
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“…[Image: see text] Siderophores are small-molecule high-affinity multidentate chelators selective for ferric iron that are produced by pathogenic microbes to aid in nutrient sequestration and enhance virulence. …”
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“…(MECQ) using different free radical scavenging assays includes DPPH, nitric oxide, superoxide, metal chelation, and hydrogen peroxide radical scavenging assays. …”
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