“…Ferroptosis is a kind of regulated cell death (RCD) caused by the redox state disorder of intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which is inhibited by iron chelators and lipophilic antioxidants. In addition to classical regulatory mechanisms, new regulatory factors for ferroptosis have been discovered in recent years, such as the P53 pathway, the activating transcription factor (ATF)3/4 pathway, Beclin 1 (BECN1) pathway, and some non-coding RNA. …”
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“…The macrocyclic cyclam moieties adopt the centrosymmetric trans-III conformation with six- and five-membered chelate rings in chair and gauche conformations. The crystal structure is stabilized by inter­molecular hydrogen bonds involving the NH or CH groups of cyclam and the NH(2) group of coordinated formamide as donors, and Cl atoms of the ZnCl(4) (2−) anion as acceptors.…”
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“…In this experiment, different concentrations of Na(2)SeO(3) and SeMet were added to MEA and PDA media to observe the effect of selenium on the sclerotium differentiation of Q1 strain, and the contents of carotenoids, ascorbic acid, and total phenol and their reducing power, DPPH free radical scavenging ability, ferrous ion chelating ability, and superoxide anion scavenging ability were determined. …”
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“…The inhibitory effect of N‐acetyl cysteine to reverse the acquired MTX resistance was greater than that of the iron chelator, deferasirox, highlighting the importance of iron‐mediated ROS in MTX resistance. …”
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“…The anti-VCAM-1 Nb functionalised with the novel restrained complexing agent (RESCA) chelator was labelled with [(18)F]AlF with a high radiochemical yield (>75%) and radiochemical purity (>99%). …”
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“…These mushroom by-products (MSW powder) contained a good source of protein (13.5%), ash (8.2%), total phenolics content (6.3 mg GAE/g), and dietary fiber (32.3%) and also exhibited the potential to be strong antioxidants, due to their good metal chelating ability (41.3%), reducing power (60.1%), and free radical scavenging activity (84.2%). …”
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“…Washing C. albicans cells with the cell-impermeable chelator, EGTA, depleted 50–90 % of cellular Ca, suggesting that a large proportion of this cation is stored in the cell wall. …”
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“…Five salicylate donors were studied. The chelate mode is the preferred adsorption mode. The linear relationship (R(2) = 0.96) between calculated adsorption energies (E(ads)) of five SIDs and the experimental PP activities was observed. …”
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“…Thus, adding Zn or Cu can decrease the toxicity of the FA by affecting the absorption or transportation of the FA in plants and mitigate toxicity possibly through chelation. Zn and Cu modify the antioxidant system to scavenge hydrogen peroxide for suppressing FA induction of oxidative damage. …”
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“…In this study, we modified the macrocyclic gallium-68 chelator fusarinine C (FSC) by conjugating a fluorescent moiety and tetrazine (Tz) moieties. …”
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“…Methods: The cationic micelles were developed as linear surfactants comprising the chelator DOTA, a triarginine sequence and a palmitoyl or stearoyl fatty acid chain. …”
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“…E. coli expressed recombinant basic fibroblast growth factor (bFGF) with histidine-tag (bFGF-His) was immobilized onto the surface of a glass plate modified with a Ni(II)-chelated alkanethiol monolayer. The immobilization is expected to take place through the coordination between Ni(II) and His-tag. …”
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“…A Ca(2+) channel inhibitor, La(3+), a Ca(2+)chelator, EGTA, and an inhibitor of Ca(2+) release from internal stores, nicotinamide, inhibited AITC-induced [Ca(2+)](cyt) elevation and stomatal closure, but did not affect inhibition of light-induced stomatal opening. …”
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“…To this end, we modified AR20.5 with the chelator desferrioxamine (DFO) and labeled it with the positron-emitting radiometal zirconium-89 (t(1/2) ~3.3 d) to produce [(89)Zr]Zr-DFO-AR20.5. …”
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“…Deferasirox (DFX) is an oral iron-chelating agent and classified into class II of the Biopharmaceutics Classification System. …”
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“…Several proposed ligands fail to meet rigorous binding criteria, including the bacterial siderophore pyochelin, the iron-chelating catecholamine hormone norepinephrine, and the bacterial second messenger cyclic diguanylate monophosphate. …”
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“…Co-exposure tests with the antioxidant N-acetyl-l-cysteine and the Cu chelator bathocuproinedisulfonic acid disodium salt demonstrated that Cd toxicity was due to the oxidative stress caused by Cu, and that Cu at a low concentration could in fact exert an antioxidant effect against the oxidative stress in ZFL. …”
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“…Furthermore, the inhibition of intracellular Ca(2+) by BAPTA-AM, a Ca(2+) chelator, significantly suppressed the CSP32-mediated phagocytosis, inflammatory mediator production, and NF-κB activation. …”
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“…It is proposed that RB phenolic extracts, via their metal chelating properties and free radical scavenging activity, target pathways of oxidative stress and inflammation resulting in the alleviation of vascular inflammatory mediators.…”
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“…For the antioxidant capacity, four different assays were used namely: 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay (DPPH(•)); Ferrous ions chelating activity (FIC); Ferric reducing antioxidant power (FRAP) and 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging assay (ABTS(•+)). …”
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