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11921“…The m-bdc(2−) ligands adopt a chelate-monodentate coordination mode, connecting neighboring Cd(II) ions into a zigzag chain parallel to [110]. …”
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11922por Romsang, Adisak, Duang-Nkern, Jintana, Leesukon, Panithi, Saninjuk, Kritsakorn, Vattanaviboon, Paiboon, Mongkolsuk, Skorn“…The expression of iscR was highly induced through the exposure of the bacteria to various oxidants, such as peroxides, redox-cycling drugs, intracellular iron-chelating agents, and high salts. Two putative type 1 IscR-binding sites were found around RNA polymerase recognition sites, in which IscR-promoter binding could preclude RNA polymerase from binding to the promoter and resulting in repression of the isc operon expression. …”
Publicado 2014
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11923“…The highest ability to chelate Fe(2+) was observed for GH tincture (EC(50) = 71.01 ± 3.55 mg FM/mL), whereas the lowest was observed (EC(50) = 131.06 ± 6.55 mg FM/mL) for F3 tincture. …”
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11924por Vanoaica, Liviu, Richman, Larry, Jaworski, Maike, Darshan, Deepak, Luther, Sanjiv A., Kühn, Lukas C.“…This was partially reversed with iron-chelator deferiprone. The loss of T cells was also confirmed by a T cell-specific deletion in Fth(lox/lox);CD4-Cre mice. …”
Publicado 2014
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11925por Ablat, Abdulwali, Mohamad, Jamaludin, Awang, Khalijah, Shilpi, Jamil A., Arya, Aditya“…The ethanol extract of B. javanica seed was fractionated with solvents of different polarities and tested for antioxidant activities by several assays including DPPH radical scavenging activity, ferric reducing antioxidant power (FRAP), ferrous ion chelating activity (FCA), and nitric oxide radical scavenging activity (NORSA) along with their polyphenolic contents. …”
Publicado 2014
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11926“…Both extracts at concentration of 50 to 800 μg/mL showed appreciative metal chelating activity with IC50 value of 172.2 ± 31 μg/mL to 456.5 ± 30 μg/mL. …”
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11927“…OBJECTIVES: The objective of this in vitro study was to assess the effect of different chelating agents on the calcium loss and its subsequent effect on the microhardness of the root dentin. …”
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11928por Park, Jin-Sung, Koentjoro, Brianada, Veivers, David, Mackay-Sim, Alan, Sue, Carolyn M.“…The toxic effect of Zn(2+) was blocked by ATP13A2 overexpression, Zn(2+) chelation, antioxidant treatment and promotion of mitochondrial fusion. …”
Publicado 2014
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11929por Oono, Youko, Yazawa, Takayuki, Kawahara, Yoshihiro, Kanamori, Hiroyuki, Kobayashi, Fuminori, Sasaki, Harumi, Mori, Satomi, Wu, Jianzhong, Handa, Hirokazu, Itoh, Takeshi, Matsumoto, Takashi“…Upregulation of various ROS-scavenging enzymes, chelators and metal transporters demonstrated the appropriate expression profiles to Cd exposure. …”
Publicado 2014
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11930por Ahmad, Asad A, Wang, Yuli, Gracz, Adam D, Sims, Christopher E, Magness, Scott T, Allbritton, Nancy L“…RESULTS: An optimal incubation time of 60 min in a chelating buffer released 280,000 ± 28,000 crypts from the stroma of a single colon with 79.3% remaining intact. …”
Publicado 2014
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11931“…Precisely how the protozoan acquires its iron from its mammalian host remains unclear, but iron chelators can inhibit pathogen growth in vitro and in animal models. …”
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11932por Smallwood, Chuck R., Jordan, Lorne, Trinh, Vy, Schuerch, Daniel W., Gala, Amparo, Hanson, Mathew, Shipelskiy, Yan, Majumdar, Aritri, Newton, Salete M.C., Klebba, Phillip E.“…This sequence suggested that the loops bind the metal complex like the fingers of two hands closing on an object, by individually adsorbing to the iron chelate. Fluorescence from L3 followed a biphasic exponential decay as FeEnt bound, but fluorescence from all the other loops followed single exponential decay processes. …”
Publicado 2014
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11933por Temma, Takashi, Hanaoka, Hirofumi, Yonezawa, Aki, Kondo, Naoya, Sano, Kohei, Sakamoto, Takeharu, Seiki, Motoharu, Ono, Masahiro, Saji, Hideo“…METHODS: We designed and synthesized MDAP(1000), MDAP(3000), and MDAP(5000), which consist of 4 independent moieties: RI unit ((111)In hydrophilic chelate), MMP-2 substrate unit (short peptide), anchoring unit (alkyl chain), and anchoring inhibition unit (polyethylene glycol (PEGn; where n represents the approximate molecular weight, n = 1000, 3000, and 5000). …”
Publicado 2014
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11934“…The mutant failed to grow on medium supplemented with iron chelator and grew less efficiently in deferrated broth indicating its higher iron requirement. …”
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11935por Laurier-Laurin, Marie-Elaine, De Montigny, Audrée, Attiori Essis, Suzanne, Cyr, Michel, Massicotte, Guy“…From a biochemical perspective, we observed that Tau phosphorylation at the Ser262 epitope was highly increased in hippocampal slices preincubated with the ACI, an effect totally prevented by the global NMDA receptor antagonist D/L(−)-2-amino-5-phosphonovaleric acid (AP-5), the calcium chelator 1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA), and the GluN2B (but not the GluN2A) receptor antagonist RO25-6981. …”
Publicado 2014
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11936por Brugger, Dagmar, Krondorfer, Iris, Shelswell, Christopher, Huber-Dittes, Benjamin, Haltrich, Dietmar, Peterbauer, Clemens K.“…Alternative electron acceptors including quinones, radicals or chelated metal ions show significant and in some cases even higher activity. …”
Publicado 2014
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11937por Gaddy, Jennifer A., Radin, Jana N., Loh, John T., Piazuelo, M. Blanca, Kehl-Fie, Thomas E., Delgado, Alberto G., Ilca, Florin T., Peek, Richard M., Cover, Timothy L., Chazin, Walter J., Skaar, Eric P., Scott Algood, Holly M.“…Neutrophils participate in this process by producing several metal chelating proteins, including lactoferrin and calprotectin (CP). …”
Publicado 2014
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11938“…Among the synthesized compounds (4a–r), the compound 4e exhibited highest activity for radical scavenging and ferric ions reducing antioxidant power activities; compounds 4b, 4h, and 4k showed good metal chelating activity. Compounds 4n and 4q showed excellent antimicrobial activities with MIC value 08 µg/mL against tested strains. …”
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11939por Gomez, Mauricio, Pérez-Gallardo, Rocío V., Sánchez, Luis A., Díaz-Pérez, Alma L., Cortés-Rojo, Christian, Meza Carmen, Victor, Saavedra-Molina, Alfredo, Lara-Romero, Javier, Jiménez-Sandoval, Sergio, Rodríguez, Francisco, Rodríguez-Zavala, José S., Campos-García, Jesús“…ISC mutants showed increased free Fe(2+) content, exacerbated by ROS-inducers, causing an increase in ROS, which was decreased by the addition of an iron chelator. Our study suggests that the increment in free Fe(2+) associated with ROS generation may have originated from mitochondria, probably Fe–S cluster proteins, under both normal and oxidative stress conditions, suggesting that Fe–S cluster anabolism is affected. …”
Publicado 2014
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11940por Mashhadi, Mohammad Ali, Sepehri, Zahra, Heidari, Zahra, Shirzaee, Eghbal, Kiani, Zohre“…About 27% (90) of the cases were 5-10 years-old, 24% (80) were 10-15 years-old and 49% were older than 15 years old. Iron chelator in 65.46% was Desferrioxamine, in 28.2% was Deferasirox and in 19.5% was combination of Desferrioxamine and Deferiprone. …”
Publicado 2014
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