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  1. 12061
    “…Pharmacological data showed that glucose-induced stomatal closure was greatly inhibited by catalase [CAT; a reactive oxygen species (ROS) scavenger], diphenyleneiodonium chloride (DPI; an NADPH oxidase inhibitor), lanthanum chloride (LaCl(3); a Ca(2+) channel blocker), EGTA (a Ca(2+) chelator), and two nitrate reductase (NR) inhibitors, tungstate and sodium azide (NaN(3)), while it was not affected by salicylhydroxamic acid (SHAM; a peroxidase inhibitor). …”
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    Glucose triggers stomatal closure mediated by basal signaling through HXK1 and PYR/RCAR receptors in Arabidopsis
  2. 12062
    por Taoka, Toshiaki, Naganawa, Shinji
    Publicado 2018
    “…Gd deposition in brain tissue after repeated administration of gadolinium-based contrast medium (GBCM) has been histologically proven, and chelate stability has been shown to affect the deposition. …”
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    Gadolinium-based Contrast Media, Cerebrospinal Fluid and the Glymphatic System: Possible Mechanisms for the Deposition of Gadolinium in the Brain
  3. 12063
    “…Further investigation is required to develop safe iron chelators as effective treatment strategies against obesity, with potential for rapid clinical application.…”
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    Deferoxamine ameliorates adipocyte dysfunction by modulating iron metabolism in ob/ob mice
  4. 12064
    “…An iron chelate, ferric nitrilotriacetate (Fe‐NTA), induces renal proximal tubular damage, a consequence of iron‐catalyzed free radical reactions, that finally leads to a high incidence of renal cell carcinoma (RCC) in rodents. …”
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    Low Incidence of Point Mutations in H‐, K‐ and N‐ras Oncogenes and p53 Tumor Suppressor Gene in Renal Cell Carcinoma and Peritoneal Mesothelioma of Wistar Rats Induced by Ferric Nitrilotriacetate
  5. 12065
    “…Although the research on nanogels incorporating Gd chelates for theranostic applications has grown exponentially in recent years, knowledge about their biocompatibility is limited. …”
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    Biocompatibility of Gd-Loaded Chitosan-Hyaluronic Acid Nanogels as Contrast Agents for Magnetic Resonance Cancer Imaging
  6. 12066
    “…Subclinical hypothyroidism was found in six patients (21 %). Intensive chelation therapy had allowed the reversibility of this complication in five cases. …”
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    Growth and Endocrine Function in Tunisian Thalassemia Major Patients
  7. 12067
    “…The recombinant DgK was affinity purified using Ni²(+)-charged HiTrap chelating column, followed by testing in Western blotting and enzyme-linked immunosorbent assays (ELISA) with dog sera from a dirofilariasis endemic area. …”
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    Development of New Recombinant DgK Antigen for Diagnosis of Dirofilaria immitis Infections in Dogs Using ELISA Technique and Its Comparison to Molecular Methods
  8. 12068
    “…OBJECTIVES: To investigate the role of diethyldithiocarbamate (DEDTC) in cyclophosphamide (CP)-induced nephrotoxicity in Sprague–Dawley rat. DEDTC is a known chelating agent for copper and zinc. It is also used as a thiol protecting agent, as nuclear factor kappa-light-chain-enhancer of activated B-cells inhibitor and nitric oxide synthase inhibitor. …”
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    Effect of diethyldithiocarbamate in cyclophosphamide-induced nephrotoxicity: Immunohistochemical study of superoxide dismutase 1 in rat
  9. 12069
    “…Our results demonstrated that in NSC-34 and SK-N-BE cells mutated SOD1(G93A) carried out a more evident activation of ERK1-2 and AKT and a stronger increase of intracellular calcium levels compared to SOD1(WT); we also demonstrated that these effects are mediated by the M1 receptor as shown using pirenzepine, a specific M1 inhibitor and the calcium chelator BAPTA. Of note, M1 receptor pathway activation by SOD1G93A, but not by SOD1WT, is associated with both an increase of reactive oxygen species and a cytotoxic effect.…”
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    Effect of Mutated Cu, Zn Superoxide Dismutase (SOD1(G93A)) on Modulation of Transductional Pathway Mediated by M1 Muscarinic Receptor in SK-N-BE and NSC-34 Cells
  10. 12070
    “…Surprisingly, whereas calcium chelation reduced NET release induced by amoebas, PAD4 inhibition by GSK484 failed to block DNA extrusion but, as expected, abolished NETosis induced by the calcium ionophore A23187. …”
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    Entamoeba histolytica Trophozoites Induce a Rapid Non-classical NETosis Mechanism Independent of NOX2-Derived Reactive Oxygen Species and PAD4 Activity
  11. 12071
    “…CONCLUSION: Berberine protects the liver and kidneys against ferrous sulfate-induced toxicity by reduction in lipid peroxidation and ability to chelate iron.…”
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    Berberine protects the liver and kidney against functional disorders and histological damages induced by ferrous sulfate
  12. 12072
    por Abdulaal, Wesam H.
    Publicado 2018
    “…Hg(2+) and Cd(+ 2) strongly inhibited the activity of A4. EDTA as metal chelator caused strong inhibitory effect. CONCLUSIONS: The properties of the purified α-amylase A4 from T. pseudokoningii meet the prerequisites needed for several applications.…”
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    Purification and characterization of α-amylase from Trichoderma pseudokoningii
  13. 12073
    “…A new class of cyclometalated Ir(iii) complexes supported by various bidentate C-deprotonated (C^N) and cis-chelating bis(N-heterocyclic carbene) (bis-NHC) ligands has been synthesized. …”
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    Stable luminescent iridium(iii) complexes with bis(N-heterocyclic carbene) ligands: photo-stability, excited state properties, visible-light-driven radical cyclization and CO(2) reduction, and cellular imaging
  14. 12074
    “…It also exhibited the highest DPPH, FRAP, metal chelating, hydrogen peroxide, nitric oxide superoxide radical scavenging activity. …”
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    The Antioxidant and Xanthine Oxidase Inhibitory Activity of Plumeria rubra Flowers
  15. 12075
    “…Iron is an essential micronutrient for most bacteria and is obtained from iron-chelating siderophores or directly from iron-containing host proteins. …”
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    Bacterial iron acquisition mediated by outer membrane translocation and cleavage of a host protein
  16. 12076
    “…Bisphosphonates (BPs) have high affinity to calcium ions and are effective calcium chelators. Therefore, BPs could potentially be used as antibacterial agents. …”
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    Engineering of a New Bisphosphonate Monomer and Nanoparticles of Narrow Size Distribution for Antibacterial Applications
  17. 12077
    “…Although the use of acetic acid as the chelating agent leads to micrometric particles with heterogeneous composition, the presence of hydroxypropylcellulose (HPC) results in smaller, less aggregated particles as well as in a high phase purity. …”
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    Sol–Gel Synthesis of CaTiO(3):Pr(3+) Red Phosphors: Tailoring the Synthetic Parameters for Luminescent and Afterglow Applications
  18. 12078
    “…We, therefore, explored four strategies to deplete or fragment extraneous DNA in RPA reagents while preserving enzyme activity: metal-chelate affinity chromatography, sonication, DNA cleavage using methylation-dependent restriction endonucleases, and DNA depletion using anti-DNA antibodies. …”
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    Akkermansia muciniphila as a Model Case for the Development of an Improved Quantitative RPA Microbiome Assay
  19. 12079
    “…Other competition experiments using the 2-DR assay (varying pre-incubation time and 2-DR concentration) indicated that protection comes mainly from free radical scavenging, rather that metal chelation antioxidant activity. Persimmon extracts prevented iron-mediated lipid peroxidation in rat liver homogenates, which correlated significantly with the inhibition of 2-DR oxidation. …”
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    Antioxidant activity and mechanism of commercial Rama Forte persimmon fruits (Diospyros kaki)
  20. 12080
    “…All except two patients were receiving iron chelator medication of which the most commonly used was oral deferasirox (92%). …”
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    Body iron status of children and adolescents with transfusion dependent β-thalassaemia: trends of serum ferritin and associations of optimal body iron control
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