“…We hypothesize that the neuroprotective effects of iron chelators are acting against the generation of free radicals derived from iron, and also induce sufficient -but not excessive- activation of HIF-1α, so that only the hypoxia-rescue genes will be activated. …”
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“…Such effects of HX109 on AR signaling were mediated through the control of activating transcriptional factor 3 (ATF3) expression, phosphorylation of calcium/calmodulin-dependent protein kinase kinase β (CaMKKβ), and increases in intracellular calcium, as evidenced by data from experiments involving ATF3-specific siRNA, CaMKKβ inhibitor, and calcium chelator, respectively. Taken together, our data suggest that HX109 might be used as a starting point for developing therapeutic agents for the treatment of BPH.…”
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“…Compound 6b(1), the optimal compound, was able to selectively chelate copper (II), and inhibit Cu(2+)-induced Aβ aggregation effectively. …”
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“…While the modification of appendage VI into a broad swimming paddle allies Hoplitaspis to the Diploaspididae, the paddle lacks the anterior ‘podomere 7a’ found in other diploaspidids and shows evidence of having been derived from a Chasmataspis-like chelate appendage. Other details, such as the large body size and degree of expression of the first tergite, show clear affinities with Chasmataspis, providing strong support for chasmataspidid monophyly. …”
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“…By binding to the Aβ histidine residues, catalytic amounts of chlorin e6 can also inhibit the Cu(2+)-induced aggregation and toxicity in darkness, while at stoichiometric amounts it acts as a chelator to reduce the amount of free Cu(2+). This study demonstrates the great potential of chlorin e6 as a multifunctional agent for treatment of AD, and shows that the three N-terminal Aβ histidine residues are a suitable target for Aβ-specific drugs.…”
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“…Ovotransferrin (OTF) is a well-known protein of the transferrin family with strong iron chelating activity, resulting in its antimicrobial activity. …”
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“…Embelia ribes, Cassia occidentalis and Coscinium fenestratum fractions inhibited the ACE by Zn(2+) ion chelation. Research revealed the potential of tested plants fractions as ACE inhibitors along with their inhibition kinetics and mechanism of inhibition. …”
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“…In an engineered receptor containing a binding site for Zn(+2) ions in a complex with an aromatic chelator (phenanthroline or bipyridine), a ligand-driven inhibition of both the receptor signaling and MHC class I downregulation was observed. …”
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“…Its asymmetric unit comprises one BTA anion coordin­ating to the Cu(2+) cation (site symmetry [Image: see text]) through the carboxyl O atom, and one MEA ligand chelating the metal cation by two heteroatoms (O and N). …”
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“…Total phenolic content (TPC), total flavonoid content (TFC), total antioxidant capacity (TAC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, and ferrous ion chelating assay were evaluated. A total of 74 compounds were identified from the GC-MS analysis of the EA extract representing mostly alkane compounds followed by phenols, carboxylic acids, aromatic heterocyclic compounds, ketones, aromatic esters, aromatic benzenes, and alkenes. …”
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“…Production of siderophores, which are iron-chelators, was much higher in Xag(EadM). As in Xag, Escherichia coli expressing EadM showed significantly reduced (1000-fold) viable cell numbers at the same optical density. …”
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“…In this review, we examine the recent advances about the potential role of dysregulated iron homeostasis in neurodegeneration, with an emphasis on AD and PD, and we discuss iron chelation as a potential therapy. This review also highlights the changes in iron homeostasis caused by NO. …”
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“…This glutamate-driven neuronal death can be attenuated by iron-chelating compounds or free radical scavenger molecules. …”
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“…In this study, we treated herbaceous peony (Paeonia lactiflora Pall.) with ethyl glycol tetraacetic acid (EGTA), an effective Ca(2+) chelator, and used morphology indicators, spectroscopic analysis, histochemical staining, electron microscopy, and proteomic techniques to investigate the role of Ca(2+) in inflorescence stem mechanical strength. …”
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“…The phenyl ring on PS chain backbone tends to have a parallel configuration in the vicinity of C [Formula: see text] surface, therefore neighbouring phenyl rings can form chelation effect on the C [Formula: see text] surface. …”
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“…Using the high-dilution coupling of the bi-functional monomers maleic acid and bis(chloroethyl)ether in a sol-gel chemistry synthesis, 11-membered chelate rings infused with three oxygen donor atoms were created and characterized, and their structures confirmed using Fourier transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopic analyses. …”
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“…Within these environmental and public health frameworks, we are combining the salient features of clays and chelatant polymers to design selective metal ion adsorbents. …”
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“…Meanwhile, Ca(2+) significantly down-regulated CsETR1, CsETR2, CsERS, and CsCTR1, but positively up-regulated the expression of CsEIN2 and CsEIN3 under salt stress; however, the application of Ca(2+) chelators or channel inhibitors could obviously reverse the effects of Ca(2+) on the expression of the above genes. …”
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“…The gintonin-mediated increase in the release of VEGF was inhibited by the LPA1/3 receptor antagonist, Ki16425; phospholipase C inhibitor, U73122; inositol 1,4,5-triphosphate receptor antagonist, 2-APB; and intracellular Ca(2+) chelator, BAPTA. Hypoxia further stimulated astrocytic VEGF release. …”
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“…They are radical scavengers and metal chelators, but due to their low concentration in biological fluids in vivo their antioxidant properties seem to be related to enhanced endogenous antioxidant capacity induced via signalling through the Nrf2 pathway. …”
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