“…Patch clamp recording of recombinant Cav3.2 currents revealed that two cysteine-modifying agents, sodium (2-sulfonatoethyl) methanethiosulfonate (MTSES) and N-ethylmaleimide, as well as a reactive oxygen species–producing neuropeptide, substance P (SP), inhibit Cav3.2 current to similar degrees and that this inhibition is reversed by a reducing agent and a zinc chelator. Pre-application of MTSES prevented further SP-mediated current inhibition. …”
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“…The addition of fullerenol to Fe(II)-sulfate solutions significantly increased leaf-active Fe (extracted by an Fe(II) chelator) and re-greening at the site of application. …”
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“…Clinical management is complex and long-term and includes regular blood transfusion and iron chelation therapy. The economic burden of β-thalassaemia for the Sri Lankan healthcare system and households is currently unknown. …”
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“…All three Ca(2+) fluorescent probes successfully entered the cytoplasm but did not enter the vacuole. Both the Ca(2+) chelator (EGTA) and Ca(2+) channel blocker (La(3+)) reduced the fluorescence intensity in the cytoplasm. …”
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“…The base of the pyramid consists of two nitro­gen atoms from the bidentate chelate L [Cu—N = 2.0241 (9), 2.0374 (8) Å] and two chlorine atoms [Cu—Cl = 2.2500 (3), 2.2835 (3) Å]. …”
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“…In the complexes bearing the 2-iPrC(6)H(4)C(H)-moiety, the chelation framework forms a plane; however, this framework is distorted in the complexes containing the PhC(H)-moiety. …”
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“…The unreacted NODAGA chelator was separated using the ion-suppression reverse phase-high performance liquid chromatography (RP-HPLC) method, and the freeze-dried NODAGA-pamidronic acid was radiolabeled with (68)Ga. …”
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“…Extracellular Ca(2+) reduction with a Ca(2+) chelator inhibited high-K(+)-induced increase in [Ca(2+)](in) and NCC dephosphorylation. …”
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“…Intracellular Ca(2+) chelation and substitutive mutations of the conserved cytosolic Ca(2+)-binding domain lowered rsTRPA1 thermosensitivity comparable to that of bTRPA1. …”
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“…Deferiprone (DFP), also known as Ferriprox, is an FDA-approved, orally active, iron chelator that is currently used clinically for the treatment of iron-overload, especially in thalassaemia major. …”
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“…There are limited options to manage secondary iron overload in patients with CKD as most iron chelators are contraindicated due to low creatinine clearance. …”
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“…The effect of metal ion chelation was evaluated as well as substitutions of residues involved in metal ion binding. …”
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“…Structural data for 2, 3, and 5 from single-crystal X-ray diffraction analysis reveal a distinctive widening of the daf and Me(2)daf chelate angles in comparison to the analogous Mn(CO)(3)(bpy)Br (1) and [Ru(bpy)(3)](2+) (4) complexes. …”
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“…Hb displays a very high conjugation yield in its fast and selective reaction with the maleimide-deferoxamine (DFO) bifunctional chelator. The high-resolution X-ray structure of the Hb-DFO complex demonstrated that cysteine β93 is the sole attachment moiety to the αβ-protomer of Hb. …”
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“…In each complex mol­ecule, the Fe(II) cation is coordinated by the two N atoms of a 5-bromo-1,10-phenanthroline ligand and by two pairs of N atoms of chelating di­hydro­bis(pyrazol-1-yl)borate ligands in the form of a slightly distorted octa­hedron. …”
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“…Chitosan has amino groups through which metals can be complexed easily to chelates. The physical and chemical modification of chitosan on wool was performed to analyze the influence of the coating bond on the final ability of the wool to remove metals. …”
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“…These effects were alleviated by propofol, calcium chelator, CAMK II inhibitor, calpain‐2 inhibitor, calpain‐2 siRNA transfection and N‐Methyl‐d‐aspartic acid (NMDA) receptor antagonist. …”
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“…The coding sequences were expressed in E. coli and purified by Ni-chelate chromatography. The CoA ligases exhibited different substrate specificities. 4CL catalyzed the activation of 4-coumaric acid, 3-coumaric acid, 2-coumaric acid, caffeic acid, isoferulic acid, ferulic acid, and cinnamic acid but lacked activities towards sinapic acid and benzoic acids. …”
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“…This study highlights the metal chelating potency as the possible therapeutic target for neurological diseases.…”
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“…METHODS: GFc7 growth nanofactor was synthesized based on nanochelating technology as an iron-containing copper chelator nanocomplex. The effect of this nanocomplex on the expansion and differentiation of hematopoietic stem cells (HSCs) as well as its performance as a cryoprotectant was evaluated in the present study. …”
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