“…Sensitivity to a variety of reagents, i.e., detergents, reducing, and chelating agents as well as classic acid phosphatase inhibitors was examined in addition to assessment of hydrolysis of a number of phosphorylated compounds. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Background: Standard of care (SoC) for transfusion-dependent β-thalassemia (TDT) requires lifelong, regular blood transfusions as well as chelation to reduce iron accumulation. Objective: This study investigates the cost-effectiveness of betibeglogene autotemcel (‘beti-cel’; LentiGlobin for β-thalassemia) one-time, gene addition therapy compared to lifelong SoC for TDT. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…There is no proven treatment and patients experience slow progression of symptoms. Iron-chelating agents have been suggested as a therapeutic option and deferiprone is suited as it crosses the blood-brain barrier. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…D-penicillamine with supplements was started due to unavailability of other chelating agents. Encephalopathy improved, but patient had psychiatric symptoms of hallucinations and delusions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we present a new squaramide-containing compound targeting FAP, based on the AAZTA(5) chelator 1,4-bis-(carboxylmethyl)-6-[bis-(carboxymethyl)-amino-6-pentanoic-acid]-perhydro-1,4-diazepine. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, aminated hyaluronic acid (aHA) coupled with 2,3-dimethylmaleic anhydride (DMA, as a pH-responsive moiety) (aHA-DMA) was electrostatically complexed with ferrous chloride tetrahydrate (FeCl(2)/4H(2)O, as a chelating metal) and doxorubicin (DOX, as an antitumor drug model), producing DOX-loaded Fe-based hyaluronate nanoparticles (DOX@aHA-DMA/Fe NPs). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This glycoprotein possesses antimicrobial activity due to its capability to chelate two ferric ions per molecule, as well as to interact with bacterial and viral anionic surface components. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Based on the candidate gene annotation and gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) function analysis, miR167a, novel_miR15, and novel_miR22 and their targets were potentially involved in Cr transportation and chelation. Besides, miR156a, miR164, miR396d, and novel_miR155 were identified as participating in the physiological and biochemical metabolisms and the detoxification of Cr of plants. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Forward and reverse genetics have led to the identification of mechanisms that are used by beneficial microorganisms to overcome these challenges, such as the production of iron-chelating compounds, the formation of strong biofilms, or the concealment of characteristic microbial molecular patterns that trigger the host immune system. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…All of the patients were on Desferal chelation therapy and none of them had clinical signs of heart failure. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We also observed a significant decrease in the blood metal content in the animals treated with lipoic acid compared to the lead-administered group, indicating the moderate chelating property of lipoic acid. It may thus be concluded that lipoic acid might be a promising protective agent against lead and ZnO NP–induced alterations in the neurological, immunological, and reproductive parameters.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Phorbol 12-myristate 13-acetate (PMA), an activator of PKC, also mediated stimulation of Na-K-ATPase like LTD4, while BAPTA-AM (Ca chelator) and calphostin-C (Cal-C; PKC inhibitor) prevented the stimulation of Na-K-ATPase activity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Radioactive labeling with gallium-68 allowed us to perform in vitro characterization (distribution coefficient, stability, uptake assay) as well as biodistribution experiments and PET/CT imaging in an IPA rat infection model. Compounds chelated with stable gallium were used for antifungal susceptibility tests. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The Ca(2+) selective chelating activity of caffeic or ferulic acids provides elements to be investigated for their possible use as an alternative to mugwort extract.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The treatment of Arabidopsis seeds with calcium ions (Ca(2+)) increased the H(2)O(2) levels in the seedlings under HS treatment, whereas treatment with a Ca(2+) chelator (EGTA) inhibited it, indicating that CNGC6 may stimulate the accumulation of H(2)O(2) in a manner dependent on an increase in cytosolic Ca(2+) ([Ca(2+)](cyt)). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Herein, we present novel EV purification methods focused on optimized timing and levels of temperature and divalent cation chelation. Incorporation of these solubilization steps into centrifugation- and tangential flow filtration-based methods provide large amounts of purified small EVs at ultra-dense concentrations, which are substantially free from contaminating milk proteins. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Most of the T(3) effects, including mTOR activation, UCP1 upregulation, and OCR increase, were abrogated by intracellular Ca(2+) chelation with BAPTA-AM. Calmodulin inhibition with W7 or knockdown of MCU dampened T(3)-induced mitochondrial activation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The DNA–chitosan hydrogel matrix contains (i) cationic (NH(3)(+)) and anionic (PO(4)(−)) sites for electrostatic binding with ionic species, (ii) -OH and -NH(2) groups and heteroaromatic DNA nucleobases for chelation of heavy metal ions, and (iii) DNA double-helix for recognition and binding to small organic molecules of various structures and polarities. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We report here on the synthesis of a new heteroleptic molecular precursor containing (i) a thiolate ligand forming a direct Sn-S bond, and (ii) a chelating O^N^N-donor ligand introducing a “launch vehicle”-effect into the synthesized compound, thus remarkably increasing its volatility. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Water-soluble saccharides are converted into saccharic acid after dissolving in water, then a saccharide–calcium complex with a pompon-like structure is formed through a reaction between saccharic acid and calcium ions of Portland cement hydrates, and the saccharide–calcium complex covers the surfaces of the cement particles and prevents further hydration of the cement, achieving a certain anticoagulation effect on Portland cement; a chelation reaction between the carboxyl of the organic carboxylic acid and the calcium ions of Portland cement hydrates takes place and the concentration of calcium ions in the hydration system is reduced, which exerts an influence on further hydration process of Portland cement and achieves a certain anticoagulation effect. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso